Mouse β3a and β3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

British Journal of Pharmacology

Volumn 135, Issue 8, 2002, Pages 1903-1914

  Hutchinson, Dana S ^a,b   Bengtsson, Tore ^b   Evans, Bronwyn A ^a   Summers, Roger J ^a  

^a MONASH UNIVERSITY   (Australia)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Cyclic AMP; Mouse; Splice variant cytosensor microphysiometer Erk1 2

Indexed keywords

1 (2 ETHYLPHENOXY) 3 (1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINO) 2 PROPANOL OXALATE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ALPRENOLOL; ANTIBIOTIC G 418; APROTININ; BACITRACIN; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUPRANOLOL; CHOLERA TOXIN; CYANOPINDOLOL I 125; CYCLIC AMP; FORSKOLIN; GENISTEIN; GR 265162X; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; L 755507; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NORADRENALIN; PERTUSSIS TOXIN; SB 251023; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONCENTRATION RESPONSE; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; DIOXOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; RECEPTORS, ADRENERGIC, BETA-3; SIGNAL TRANSDUCTION;

EID: 0036250352     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704654     Document Type: Article

References (39)

1. MAP kinase activation by muopioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway
2. 2-adrenergic receptor
3. 3-adrenergic receptor is required for MAP kinase activation
4. 1A-adrenoceptor isoforms
5. i in rat adipocytes
6. Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: Evidence for signalling pathway-dependent changes in agonist potency and relative intrinsic activity
7. s
8. 3-adrenoceptor which are differentially expressed in mouse tissues
9. The 5-HT4 receptor: Molecular cloning and pharmacological characterization of two splice variants
10. 3 adrenergic receptor: New pharmacological profile and mechanism of activation
11. 3-adrenergic agonist BRL 37344 in rat white adipocytes
12. 3-adrenergic receptor gene expression and mRNA splice variants in adipocytes
13. 3-adrenergic receptors: Involvement of the seventh transmembrane region in conferring subtype specificity
14. 3-adrenoceptor-transmembrane residues involved in ligand binding and signal transduction
15. 3-adrenergic receptor
16. Two isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive activity
17. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: Species differences due to altered intron-exon organization
18. 1c-adrenoceptor splice variants
19. 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors
20. 3Adrenoceptor regulation and relaxation responses in mouse ileum
21. Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase
22. Constitutive activity of human prostaglandin E receptor EP3 isoforms
23. Agonist-receptor efficacy I: Mechanisms of efficacy and receptor promiscuity
24. Agonist-receptor efficacy II: Agonist trafficking of receptor signals
25. 2 generation in human adipocyte plasma membranes is mediated by βγ-subunits derived from Gs
26. 2-adrenergic receptor
27. 1-adrenergic Erk1/2 activation is Src but not Gi-mediated in brown adipocytes
28. Regulation of tyrosine kinase cascades by G-protein-coupled receptors
29. 2adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor
30. The cytosensor microphysiometer: Biological applications of silicon technology
31. 2-adrenoceptor
32. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity
33. Molecular cloning and functional characterization of a rat somatostatin sst2(b) receptor splice variant
34. 3-adrenoceptors compared in brown adipose tissue and in skeletal muscle membranes
35. 3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism
36. The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization
37. 3adrenergic-receptor genes
38. Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras
39. 3-adrenoceptor depends on receptor expression level and nature of assay