Agonist interactions with chimeric and mutant β1- and β3-adrenergic receptors: Involvement of the seventh transmembrane region in conferring subtype specificity

Molecular Pharmacology

Volumn 53, Issue 5, 1998, Pages 856-861

  Granneman, James G ^a   Lahners, Kristine N ^a   Zhai, Ying ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 1 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; CATECHOLAMINE DERIVATIVE; ISOPRENALINE; PHENYLETHANOLAMINE DERIVATIVE; PROPRANOLOL; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; DRUG POTENCY; GENE SEQUENCE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SEQUENCE ANALYSIS;

ADRENERGIC BETA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; MOLECULAR SEQUENCE DATA; MUTATION; RATS; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-3; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0031750286     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Baldwin JM, Schertler GFX, and Unger VM (1997) An α-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J Mol Biol 272:144-164.
2. Blin N, Camoin L, Maigret B, and Strosberg AD (1993) Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor. Mol Pharmacol 44:1094-1104.
3. 3 receptors. A promising antidiabetic and antiobesity agent. J Med Chem 35:3081-3084.
4. Brown BL, Albano JDM, Ekins RP, Sgherzi AM, and Tampion W (1971) A simple and sensitive saturation assay method for the measurement of adenosine 3′,5′-cyclic monophosphate. Biochem J 121:561-562.
5. 3-adrenergic receptors to brown fat adenylyl cyclase. J Pharmacol Exp Ther 261:633-637.
6. 3-adrenergic receptor. J Pharmacol Exp Ther 271:1253-1258.
7. i in rat adipocytes. Cell Signalling 6:457-465.
8. Dixon RAF, Sigal IS and Strader CD (1988) Structure-function analysis of the β-adrenergic receptor. Cold Spring Harbor Symp Quant Biol 53:487-497.
9. 3-adrenergic receptor. Science (Washington DC) 245:1118-1121.
10. Frandsen EK and Krishna G (1976) A simple ultrasensitive method for the assay of cyclic AMP and cyclic GMP in tissues. Life Sci 18:529-542.
11. 3 adrenergic receptors to adenylyl cyclase in isolated adipocytes. J Pharmacol Exp Ther 261:638-642.
12. 3-adrenergic receptor? Cell Signalling 7:9-15.
13. 3-adrenergic receptor. Mol Pharmacol 40:885-899.
14. 3-adrenergic receptor gene. Mol Pharmacol 44:264-270.
15. 2-adrenergic receptor coupling and sequestration. J Biol Chem 269:26215-26219.
16. 3-selective agonist-induced effects on energy expenditure, insulin secretion and food intake. A study using transgenic and gene knockout mice. J Biol Chem 272:17686-17693.
17. 3-adrenergic receptor. Mol Pharmacol 48:492-498.
18. 2-adrenergic receptors. J Biol Chem 271:9335-9362.
19. 1-adrenergic receptors is lower than that of β2-adrenergic receptors. Proc Natl Acad Sci USA 90:10298-10802.
20. 2-adrenergic receptor. Proc Natl Acad Sci USA. 90:3665-3669.
21. Maniatis T, Fritsch EF, and Sambrook J (1982) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
22. Mizobe T, Maze M, Lam V, Suryanarayana S, and Kobilka BK (1996) Arrangement of transmembrane domains in adrenergic receptors. J Biol Chem 271:2387-2389.
23. Moore KR and Blakely RD (1994) Restriction site-independent formation of chimeras from homologous neurotransmitter-transporter cDNAs. Biotechniques 17:130-135.
24. 3-adrenergic receptor is resistant to short term agonist-promoted desensitization. Mol Pharmacol 43:548-555.
25. Salomon Y, Londos C, and Rodbell M (1974) Adenylate cyclase assay. Anal Biochem 58:541-548.
26. Strader CD, Sigal IS, Register RB, Candelore MR, Rands E, and Dixon RAF (1987) Identification of residues required for ligand binding to the β-adrenergic receptor. Proc Natl Acad Sci USA 84:4384-4388.
27. Strader CD, Sigal IS, Register RB, Candelore MR, Rands E, Hill WS, and Dixon RAF (1988) Conserved aspartic acid residues 79 and 113 of the β-adrenergic receptor have different roles in receptor function. J Biol Chem 263:10267-10271.
28. Strosberg AD, Camoin L, Blin N, and Maigret B (1993) In receptors coupled to GTP-binding proteins, ligand binding and G-protein activation is a multistep process. Drug Des Discover 9:199-211.
29. 3-adrenergic receptor gene. J Biol Chem 270:29483-29492.
30. 3-adrenoceptor depends on receptor expression level and nature of assay. J Pharmacol Exp Ther 279:214-221.