Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study

Hypertension Research

Volumn 25, Issue 2, 2002, Pages 179-184

  Fukuda, Masayuki ^a   Ohkubo, Takayoshi ^a   Katsuya, Tomohiro ^a   Hozawa, Atsushi ^a   Asai, Takashi ^a   Matsubara, Mitsunobu ^a   Kitaoka, Hirofumi ^a   Tsuji, Ichiro ^a   Araki, Tsutomu ^a   Satoh, Hiroshi ^a   Higaki, Jitsuo ^a   Hisamichi, Shigeru ^a   Imai, Yutaka ^a   Ogihara, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chymase; Genetics; HDL cholesterol; Hypertension; Polymorphism

Indexed keywords

ANGIOTENSIN; CHYMASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOME MONITORING; HUMAN; HUMAN TISSUE; HYPERTENSION; JAPAN; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MAJOR CLINICAL STUDY; MALE; MAST CELL; MULTIPLE REGRESSION; PREVALENCE; RURAL POPULATION;

ALLELES; CHOLESTEROL, HDL; CHYMASES; FEMALE; HETEROZYGOTE; HUMANS; MALE; MAST CELLS; MIDDLE AGED; POLYMORPHISM, GENETIC; SERINE ENDOPEPTIDASES; VARIATION (GENETICS);

EID: 0036239990     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.25.179     Document Type: Article

References (34)

1. Genetic models of human vascular disease
2. Local angiotensin II-generating system in vascular tissues: The roles of chymase
3. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
4. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
5. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study
6. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: The Suita Study
7. Ambulatory blood pressure monitoring and blood pressure self-measurement in the diagnosis and management of hypertension
8. The reproducibility of average ambulatory, home, and clinic pressures
9. Self-measurement of blood pressure improves the accuracy and reduces the number of subjects in clinical trials
10. Reproducibility of home blood pressure measurements over a 1-year period
11. Characteristics of a community-based distribution of home blood pressure in Ohasama in northern Japan
12. Prevalence of hypertension and rate of blood pressure control as assessed by home blood pressure measurements in a rural Japanese community, Ohasama
13. Relationships among blood pressures obtained using different measurement methods in the general population of Ohasama, Japan
14. Home blood pressure measurement has a stronger predictive power for mortality than does screening blood pressure measurement: A population-based observation in Ohasama, Japan
15. Clinical evaluation of semi-automatic and automatic devices for home blood pressure measurement: Comparison between cuff-oscillometric and microphone methods
16. Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid
17. Depletion of pre beta 1LpA1 and LpA4 particles by mast cell chymase reduces cholesterol efflux from macrophage foam cells induced by plasma
18. Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase: Implications for HDL function
19. Proposal of reference values for home blood pressure measurement: Prognostic criteria based on a prospective observation of the general population in Ohasama, Japan
20. Japanese individuals do not harbor the T594M mutation but do have the P592S mutation in the C-terminus of the beta-subunit of the epithelial sodium channel: The Ohasama Study
21. Serine protease angiotensin II systems
22. Biological functions of serine proteases in mast cells in allergic inflammation
23. Deletion polymorphism of ACE gene is associated with higher blood pressure after hospitalization in normotensive subjects
24. No correlation of polymorphism of angiotensin-converting enzyme genes with left ventricular hypertrophy in essential hypertension
25. Angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism in hypertensive patients with different degrees of obstructive sleep apnea
26. Effects of antihypertensive drugs and gene variants in the renin-angiotensin system
27. Association between genetic variants of mast-cell chymase and eczema
28. Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction
29. Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: The lipoprotein and coronary atherosclerosis study
30. Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy
31. Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure
32. Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: A pharmacogenetic analysis
33. The chymase A(-1903)G gene polymorphism is not associated with the risk and extent of coronary heart disease
34. Angiotensin II type 1 receptor gene A1166C polymorphism is associated with the increased risk of pregnancy-induced hypertension