Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure

American Journal of Cardiology

Volumn 82, Issue 8, 1998, Pages 979-981

  Pfeufer, Arne ^a   Busjahn, Andreas ^a   Vergopoulos, Athanasios ^a   Knoblauch, Hans ^a   Urata, Hidenori ^a   Osterziel, Karl Josef ^a   Menz, Marianne ^a   Wienker, Thomas F ^a   Faulhaber, Hans Dieter ^a   Steinmetz, Armin ^a   Schuster, Herbert ^a   Dietz, Rainer ^a   Luft, Friedrich C ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b FRANZ VOLHARD CLINIC   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE HEART INFARCTION; ADULT; ARTICLE; BLOOD PRESSURE; CHROMOSOME 14Q; FEMALE; GENE LOCATION; GENE LOCUS; GENETIC SUSCEPTIBILITY; HEART SIZE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0032532684     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(98)00518-9     Document Type: Article

References (11)

1. Schunkert H. Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease. J Mol Med 1997;75:867-875.
2. Urata H, Boehm KD, Philip A, Kinoshita A, Gabrovsek J, Bumpus FM, Husain A. Cellular localization and regional distribution of an angiotensin II-forming cymase in the heart. J Clin Invest 1993;91:1269-1281.
3. Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Blot Chem 1990;265:22348-22357.
4. Nishimura H, Hoffmann S, Balatu O, Sugimura K, Ganten D, Urata H. Angiotensin I converting enzyme and chymase in cardiovascular tissues. Kidney Int 1996;49(suppl 55):S18-S23.
5. Pfeufer A, Osterziel KJ, Urata H, Borck G, Schuster H, Wienker TF, Dietz R, Luft FC. Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy. Am J Cardiol 1996;78:362-364.
6. Schuster H, Wienker TF, Stremmler U, Noll B, Steinmetz A, Luft FC. A variant of the angiotensin converting enzyme gene is associated with myocardial infarction, but not with risk factors or severity of coronary artery disease. Am J Cardiol 1995;76:601-603.
7. Busjahn A, Knoblauch J, Knoblauch M, Bohlender J, Menz M, Faulhaber H-D, Becker A, Schuster H, Luft FC. Angiotensin converting enzyme and angio-tensinogen gene polymorphisms, plasma levels, and left ventricular size: a twin study. Hypertension 1997;29:165-170.
8. Caughey GH, Schaumberg TH, Zerwek EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ. The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage restricted expression. Genomics 1993;15:614-620.
9. Heusel JW, Hanson RD, Silverman GA, Ley TJ. Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. J Blot Chem 1991;226:6152-6158.
10. Martin N, Boomsma D, Machin G. A twin-pronged attack on complex traits. Nat Genet 1997;17:387-392.
11. Becker A, Busjahn A, Faulhaber H-D, Bahring S, Schuster H, Luft FC. Automated zygosity determination with microsatellites. J Reproductive Med 1997;42:260-266.