Depletion of Preβ1LpA1 and LpA4 particles by mast cell chymase reduces cholesterol efflux from macrophage foam cells induced by plasma

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 4, 1999, Pages 1066-1074

  Lee, Miriam ^a   Von Eckardstein, Arnold ^b   Lindstedt, Leena ^a   Assmann, Gerd ^b   Kovanen, Petri T ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

^b NONE

Author keywords

Chymase; LpA4; Mast cells; Pre 1LpA1; Proteolysis; Reverse cholesterol transport

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; CHYMASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN;

ARTERY INTIMA; ARTICLE; CELL CULTURE; CELL TRANSFORMATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; ENZYME ACTIVITY; FOAM CELL; HUMAN; HUMAN CELL; LIPOLYSIS; MAST CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE DIAGNOSIS; STATISTICAL ANALYSIS; TWO DIMENSIONAL ELECTROPHORESIS;

EID: 0032952782     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.4.1066     Document Type: Article

References (56)

1. Fielding CJ, Fielding PE. Molecular physiology of reverse cholesterol transport. J Lipid Res. 1995;36:211-228.
2. Fielding CJ, Fielding PE. Intracellular cholesterol transport. J Lipid Res. 1997;38:1503-1521.
3. Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem. 1983;52:223-261.
4. Katsuda S, Boyd HC, Flinger C, Ross R, Gown AM. Human atherosclerosis, III: immunocytochemical analysis of the cell composition of lesions of young adults. Am J Pathol. 1992;140:907-914.
5. Kovanen PT. Mast cell granule-mediated uptake of low density lipoproteins by macrophages: A novel carrier mechanism leading to the formation of foam cells. Ann Med. 1991;23:551-559.
6. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991;88:1785-1792.
7. Hurt-Camejo E, Camejo G. Potential involvement of type II phospholipase A2 in atherosclerosis. Atherosclerosis. 1997;132:1-8.
8. von Eckardstein A. Cholesterol efflux from macrophages and other cells. Curr Opin Lipidol. 1996;7:308-319.
9. Barter PJ, Rye K-A. High density lipoproteins and coronary heart disease. Atherosclerosis. 1996;121:1-12.
10. Nagano Y, Arai H, Kita T. High density lipoprotein loses its effect to stimulate efflux of cholesterol from foam cells after oxidative modification. Proc Natl Acad Sci U S A. 1991;88:6457-6461.
11. Oram JF, Mendez AJ, Slotte JP, Johnson TF. High density lipoprotein apolipoproteins mediate removal of sterol from intracellular pools but not from plasma membranes of cholesterol-loaded fibroblasts. Arterioscler Thromb. 1991;11:403-414.
12. Duell PB, Oram JF, Bierman EL. Nonenzymatic glycosylation of HDL and impaired HDL-receptor-mediated cholesterol efflux. Diabetes. 1991; 40:377-384.
13. Lee M, Lindstedt L, Kovanen PT. Mast cell-mediated inhibition of reverse cholesterol transport. Arterioscler Thromb. 1992;12:1329-1335.
14. von Eckardstein A, Huang AY, Assman G. Physiological role and clinical relevance of high-density lipoprotein subclasses. Curr Opin Lipidol. 1994;5:404-416.
15. 2. J Biol Chem. 1994; 269:11572-11577.
16. Kunitake ST, Mendel CM, Hennessy LK. Interconversion between apolipoprotein AI-containing lipoproteins of pre-beta and alpha electrophoretic mobilities. J Lipid Res. 1992;33:1807-1816.
17. Hennessy LK, Kunitake ST, Kane JP. Apolipoprotein A-I-containing lipoproteins, with or without apolipoprotein A-II, as progenitors of preβ-high density lipoprotein particles. Biochemistry. 1993;32: 5759-5765.
18. Liang H.-Q. Rye K-A, Barter PJ. Cycling of apolipoprotein A-I between lipid-associated and lipid-free pools. Biochim Biophys Acta. 1995;1257: 31-37.
19. Francone OL, Royer L, Haghpassand M. Increased preβ-HDL levels, cholesterol efflux, and LCAT mediated esterification in mice expressing the human cholesteryl ester transfer protein (CETP) and human apolipoprolein A-I (apoA-I) transgenes. J Lipid Res. 1996;37:1268-1277.
20. 1-HDL. Biochim Biophys Acta. 1996;1301:255-261.
21. Jiang X.-J, Francone OL, Bruce C, Milne R, Mar J, Walsh A, Breslow JL, Tall AR. Increased preβ-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes. J Clin Invest. 1996;98: 2373-2380.
22. Hara H, Yokoyama S. Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol. J Biol Chem. 1991;266:3080-3086.
23. Miida T, Kawano M, Fielding CJ, Fielding PE. Regulation of the concentration of preβ high-density lipoprotein in normal plasma by cell membranes and lecithin-cholesterol acyltransferase. Biochemistry. 1992; 31:11112-11117.
24. Castro GR, Fielding CJ. Early incorporation of cell-derived cholesterol into pre-β-migrating high density lipoprotein. Biochemistry. 1988;27: 25-29.
25. Kawano M, Miida T, Fielding CJ, Fielding PE. Quantitation of preβLpA1-dependent and nonspecific components of the total efflux of cellular cholesterol and phospholipid. Biochemistry. 1993;32: 5025-5028.
26. Huang Y, von Eckardstein A, Assmann G. Cell-derived cholesterol cycles between different HDLs and LDL for its effective esterification in plasma. Arterioscler Thromb. 1993;13:445-458.
27. 1-HDL and conversion into α-HDL. Evidence for disturbed HDL conversion in Tangier disease. Arterioscler Thromb Vasc Biol. 1995;15: 1746-1754.
28. Fielding PE, Kawano M, Catapano AL, Zoppo A, Marcovina S, Fielding CJ. Unique epitope of apolipoprotein A-I expressed in pre-beta-1 high density lipoprotein and its role in the catalyzed efflux of cellular cholesterol. Biochemistry. 1994;33:6981-6985.
29. Luchoomun J, Theret N, Clavey V, Duchateau P, Rosseneu M, Brasseur R, Denefle P, Fruchart J-Ch, Castro GR. Structural domains of apolipoprotein A-I involved in its interaction with cells. Biochim Biophys Acta. 1994;1212:319-326.
30. Sviridov D, Pyle L, Fidge N. Identification of a sequence in apolipoprotein A-I associated with the efflux of intracellular cholesterol to human serum and apolipoprotein A-I containing particles. Biochemistry. 1996;35:189-196.
31. von Eckardstein A, Huang Y, Wu S, Saadat Sarmadi A, Schwarz S, Steinmetz A, Assmann G. Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma. Arterioscler Thromb Vasc Biol. 1995;15:1755-1763.
32. Lindstedt L, Lee M, Castro GR, Fruchart J-C, Kovanen PT. Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid. J Clin Invest. 1996;97: 2174-2182.
33. Lindstedt KA, Kokkonen JO, Kovanen PT. Soluble heparin proteoglycans released from stimulated mast cells induce uptake of low density lipoproteins by macrophages via scavenger receptor-mediated phagocytosis. J Lipid Res. 1992;33:65-75.
34. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with Folin phenol reagent. J Biol Chem. 1951;193:265-275.
35. Woodbury RG, Everitt MT, Neurath H. Mast cell proteases. Methods Enzymol. 1981;80:588-609.
36. Saarinen J, Kalkkinen N, Welgus HG, Kovanen PT. Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. J Biol Chem. 1994;269:18134-18140.
37. Kokkonen JO, Vartiainen M, Kovanen PT. Low density lipoprotein degradation by secretory granules of rat mast cells. J Biol Chem. 1986;261: 16067-16072.
38. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345-1353.
39. Scanu A. Forms of human serum high density lipoprotein protein. J Lipid Res. 1966;7:295-306.
40. 2 and E from human plasma. J Chromatography. 1987;414:35-45.
41. Piha M, Lindstedt L, Kovanen PT. Fusion of low-density lipoprotein in the fluid phase: a novel mechanism generating atherogenic lipoprotein particles. Biochemistry. 1995;34:10120-10129.
42. Huang Y, von Eckardstein A, Wu S, Assmann G. Cholesterol efflux, cholesterol esterification and cholesteryl ester transfer by LpA-I and LpA-I/A-II in native plasma. Arterioscler Thromb Vasc Biol. 1995;15: 1412-1418.
43. Forte TM, Goth-Goldstein R, Nordhausen RW, McCall MR. Apolipoprotein AI-cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles. J Lipid Res. 1993;34:317-324.
44. Kokkonen JO, Kovanen PT. Proteolytic enzymes of mast cell granules degrade low density lipoproteins and promote their granule-mediated uptake by macrophages in vitro. J Biol Chem. 1989;264:10749-10755.
45. Kunitake ST, Chen GC, Kung S-F, Schilling JW, Hardman DA, Kane JP. Prebeta high density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis. Arteriosclerosis. 1990;10:25-30.
46. Yancey PG, Bielicki JK, Johnson WJ, Lund-Katz S, Palgunachari MN, Anamharamaiah GM, Segrest JP, Phillips MC, Rothblat GH. Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides. Biochemistry. 1995;34:7955-7965.
47. Pejler G, Berg L. Regulation of rat mast cell protease 1 activity: protease inhibition is prevented by heparin proteoglycan. uar J Biochem. 1995; 233:192-199.
48. Kaartinen M, Penttilä A, Kovanen PT. Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase/chymase-containing mast cells in normal intimas, fatty streaks and the shoulder region of atheromas. Arterioscler Thromb Vasc Biol. 1994;14:966-972.
49. Ghalim N, Adlouni A, Saile R, Parra HJ, Benslimane A, Bard JM, Fruchart JC. Apolipoprotein AIV of human interstitial fluid is associated with apolipoprotein AI-containing but not with All-containing particles. Im J Clin Lab Res. 1996;26:224-228.
50. Weinberg RB, Jordan MK. Effects of phospholipid on the structure of human apolipoprotein A-IV. J Biol Chem. 1990;265:8081-8086.
51. Oram JF, Yokoyama S. Apolipoprotein-mediated removal of cellular cholesterol and phospholipids. J Lipid Res. 1996;37:2473-2491.
52. Mendez AJ, Oram JF. Limited proteolysis of high density lipoprotein abolishes its interaction with cell-surface binding sites that promote cholesterol efflux. Biochim Biophys Acta. 1997;1346:285-299.
53. 165 → Arg). J Biol Chem. 1993;268:2616-2622.
54. Banka CL, Black AS, Curtiss LK. Localization of an apolipoprotein A-I epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells. J Biol Chem. 1994;269:10288-10297.
55. Barrans A, Jaspard B, Barbaras R, Chap H, Perret B, Collet, X. Pre-β HDL: Structure and metabolism. Biochim Biophys Acta. 1996;1300: 73-83.
56. Kaartinen M, Penttilä A, Kovanen PT. Extracellular mast cell granules carry apolipoprotein B-100-containing lipoproteins into phagocytes in human arterial intima. Functional coupling of exocytosis and phagocytosis in neighboring cells. Arterioscler Thromb Vasc Biol. 1995;15:2047-2054.