Gene transfer strategies in animal transgenesis

Cloning and Stem Cells

Volumn 4, Issue 1, 2002, Pages 39-46

  Montoliu, Lluís ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PROTEIN; ALPHA LACTALBUMIN; CASEIN; MONOPHENOL MONOOXYGENASE;

BACTERIAL ARTIFICIAL CHROMOSOME; CONFERENCE PAPER; GENE; GENE EXPRESSION; GENE TRANSFER; MAMMARY GLAND; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; REPORTER GENE; TRANSGENE; TRANSGENICS; XENOTRANSPLANTATION; YEAST ARTIFICIAL CHROMOSOME;

ANIMALIA; BACTERIA (MICROORGANISMS); VECTORS;

EID: 0036239163     PISSN: 15362302     EISSN: None     Source Type: Journal    
DOI: 10.1089/153623002753632039     Document Type: Conference Paper

References (70)

1. Expression of human erythropoietin transgenes and of the endogenous WAP gene in the mammary gland of transgenic rabbits during gestation and lactation
2. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice
3. Expression of the mouse tyrosinase gene during embryonic development: Recapitulation of the temporal regulation in transgenic mice
4. Stopped at the border: Boundaries and insulators
5. Insulators and boundaries: Versatile regulatory elements in the eukaryotic genome
6. A 17.6-kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk
7. Production of foreign proteins in the mammary glands of transgenic animals
8. Expression of synthetic cDNA sequences encoding human insulin-like growth factor-I (IGF-I) in the mammary gland of transgenic rabbits
9. YAC transgenesis in farm animals: Rescue of albinism in rabbits
10. Expression of a whey acidic protein transgene during mammary development
11. Transgenic rescue of mutant phenotypes using large DNA fragments
12. Engineering passive immunity in transgenic mice secreting virusneutralizing antibodies in milk
13. Human nerve growth factor-beta (hNGF-b): Mammary gland specific expression and production in transgenic rabbits
14. Chromatin domains as potential units of eukaryotic gene function
15. Functional gene expression domains: Defining the functional unit of eukaryotic gene regulation
16. High-level production of human growth hormone in the milk of transgenic mice: The upstream region of the rabbit whey acidic protein (WAP) gene targets transgene expression to the mammary gland
17. Chromatin structure and gene activity
18. Position-independent and high-level expression of human alpha-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA
19. High-level expressing YAC vector for transgenic animal bioreactors
20. Analysis of control elements for position-independent expression of human alpha-lactalbumin YAC
21. A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice
22. Physical mapping of the murine casein locus reveals the gene order as α-β-γ-ε-κ
23. Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene
24. The use of yeast artificial chromosomes in transgenic animals: Expression studies of the tyrosinase gene in transgenic mice
25. Size matters: Use of YACs, BACs and PACs in transgenic animals
26. Engineering mammalian chromosomes
27. Production of pharmaceutical proteins from transgenic animals
28. Transgenic animal bioreactors
29. Phenotypic rescue of the albino mutation in the medakafish (Oryzias latipes) by a mouse tyrosinase transgene
30. Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant
31. Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice
32. Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits
33. A position-effect assay for boundaries of higher order chromosomal domains
34. A group of scs elements function as domain boundaries in an enhancer-blocking assay
35. The mouse tyrosinase promoter is sufficient for expression in melanocytes and in the pigmented epithelium of the retina
36. Position-independent expression of whey acidic protein transgenes
37. Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains
38. Partial rescue of GATA-3 by yeast artificial chromosome transgenes
39. Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus
40. Yeast artificial chromosome libraries containing large inserts from mouse and human DNA
41. Distal regulatory elements required for rat whey acidic protein gene expression in transgenic mice
42. Transgenic rabbits as bioreactors for the production of human growth hormone
43. The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits
44. Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice
45. Severe position effects imposed on a 1-kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions
46. YACs, BACs, PACs and MACs: Artificial chromosomes as research tools
47. Generation of transgenic mice with yeast artificial chromosomes
48. A locus control region at - 12 kb of the tyrosinase gene
49. Techniques: Recombinogenic engineering - New options for cloning and manipulating DNA
50. Efficient and precise engineering of a 200-kb beta-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system
51. Expression of human lactoferrin in milk of transgenic mice
52. Mosaicism of tyrosinase-locus transcription & chromatin structure in dark vs. light melanocyte clones of homozygous chinchilla-mottled mice
53. A distal tyrosinase upstream element stimulates gene expression in neuralcrest-derived melanocytes of transgenic mice: Position-independent and mosaic expression
54. Structure and expression of the mouse casein gene locus
55. Organization of the bovine casein gene locus
56. Physical map and localization of the human casein gene locus
57. High-level expression of bovine S1-casein in milk of transgenic mice
58. Cloning, transcription and chromosomal localization of the porcine whey acidic protein gene and its expression in HC11 cell line
59. The mammary gland as a bioreactor: Factors regulating the efficient expression of milk protein-based transgenes
60. A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice
61. Molecular characterisation and hormone-dependent expression of the porcine whey acidic protein gene
62. Position-independent and copy-number-related expression of a goat bacterial artificial chromosome alpha-lactalbumin gene in transgenic mice
63. Association of the 5′HS4 sequence of the chicken beta-globin locus control region with human EF1 alpha gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits
64. Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene
65. Restriction map of two yeast artificial chromosomes spanning the murine casein locus
66. Position effects on eukaryotic gene expression
67. Production of pigs transgenic for human regulators of complement activation
68. A new logic for DNA engineering using recombination in Escherichia coli
69. Transgenic modification of cows milk for value-added processing
70. Expression of a 100-kb bacterial artificial chromosome (BAC) genomic clone of bovine αS1-casein in transgenic mice