Effects of endothelins on hepatic stellate cell synthesis of endothelin-1 during hepatic wound healing

Journal of Cellular Physiology

Volumn 191, Issue 3, 2002, Pages 342-350

  Shao, Rong ^a   Rockey, Don C ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 3; ENDOTHELIN RECEPTOR; SARAFOTOXIN S6C;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; IMMUNOBLOTTING; LIVER CELL; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SMOOTH MUSCLE; STELLATE CELL; WOUND HEALING;

ANIMALS; ASPARTIC ENDOPEPTIDASES; AUTOCRINE COMMUNICATION; ENDOTHELIN-1; ENDOTHELINS; LIVER; MALE; METALLOENDOPEPTIDASES; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; WOUND HEALING;

EID: 0036238984     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10110     Document Type: Article

References (61)

1. Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity
2. Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver
3. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
4. Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes
5. An oral endothelin A receptor antagonist blocks collagen synthesis and depostion in advanced rat liver fibrosis
6. Effects of nonpeptide endothelin receptor antagonists in rats with reduced renal mass
7. Type A, but not type B, endothelin receptor antagonists significantly decrease portal pressure in portal hypertensive rats
8. Detection of endothelin-1 and its receptors in rat liver endothelial cells by in situ reverse transcriptase-polymerase chain reaction
9. Regulation of endothelin synthesis in hepatic endothelial cells
10. Cellular mechanism of thrombin on endothelin-1 biosynthesis and release in bovine endothelial cell
11. Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan
12. Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats
13. An endothelin receptor antagonist TAK-044 ameliorates carbon tetrachloride-induced acute liver injury and portal hypertension in rats
14. Endothelin stimulates transforming growth factor-betal and collagen synthesis in stellate cells from control but not cirrhotic rat liver
15. Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis
16. Endothelin-1 immunoreactivity and mRNA in the transplanted human heart
17. The endothelin-1 binding site in rat liver tissue: Light- and electron-microscopic autoradiographic studies
18. The paracrine endothelin system: Pathophysiology and implications in clinical medicine
19. The dual play of endothelin receptors in hepatic vasoregulation
20. Endothelin-1 secretion by human gall bladder epithelial cells in primary culture
21. Endothelin receptors in rat liver: Lipocytes as a contractile target for endothelin 1
22. Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
23. Expression of endothelin-1 in pancreatic tissue of patients with chronic pancreatitis
24. Endothelin-1 modulates intrahepatic resistance in a rat model of noncirrhotic portal hypertension
25. Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis
26. PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury
27. Endothelins in the normal and diseased kidney
28. Mixed endothelin receptor antagonist, SB209670, decreases portal pressure in biliary cirrhotic rats in vivo by reducing portal venous system resistance
29. Prolonged bile duct obstruction: A new experimental model for cirrhosis in the rat
30. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium
31. Enhanced synthesis and reduced metabolism of endothelin-1 (ET-1) by hepatocytes - An important mechanism of increased endogenous levels of ET-1 in liver cirrhosis
32. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
33. Biliary cyst fluid from common bile duct-ligated rats stimulates endothelial nitric oxide synthase in pulmonary artery endothelial cells: A potential role in hepatopulmonary syndrome
34. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo
35. Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo
36. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors
37. Regulated expression of endothelin 1 in glomerular capillary endothelial cells
38. Endothelin-converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis
39. Circulating endothelin-1 levels in systemic sclerosis subsets - A marker of fibrosis or vascular dysfunction?
40. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients
41. Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells
42. Activation of rat hepatic stellate cells in culture is associated with increased sensitivity to endothelin 1
43. Characterization of endothelin receptors mediating rat hepatic stellate cell contraction
44. The cell and molecular biology of hepatic fibrogenesis
45. Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing
46. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture
47. Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells
48. Effect of bacterial lipopolysaccharide on endothelin-1 production in human vascular endothelial cells
49. mRNA stability in mammalian cells
50. Tissue endothelin-converting enzyme activity correlates with cardiovascular risk factors in coronary artery disease
51. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels
52. Regulation of endothelin-1 synthesis by endothelin-converting enzyme-1 during wound healing
53. Beneficial hemodynamic effects of bosentan, a mixed ET(A) and ET(B) receptor antagonist, in portal hypertensive rats
54. Overexpression of endothelin-1 in bile duct ligated rats: Correlation with activation of hepatic stellate cells and portal pressure
55. Molecular pharmacology of endothelin converting enzymes
56. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells
57. ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
58. Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide
59. Immunocytochemical detection of desmin in fatstoring cells (Ito cells)
60. Endothelin-1 secretion by human fibroblasts in culture: Effects of cell density and IFN-beta
61. Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors