Endothelins in the normal and diseased kidney

American Journal of Kidney Diseases

Volumn 29, Issue 1, 1997, Pages 2-26

  Kohan, Donald E ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

glomerulus; Receptor; renal blood flow; sodium; tubule; water

Indexed keywords

ENDOTHELIN 1;

GLOMERULUS; HUMAN; KIDNEY BLOOD FLOW; KIDNEY DISEASE; KIDNEY TUBULE ABSORPTION; MESANGIUM CELL; REVIEW; SODIUM EXCRETION; WATER ABSORPTION;

EID: 0031026198     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-6386(97)90004-4     Document Type: Review

References (260)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415, 1988
2. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Masaki T: The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A 86:2863-2867, 1989
3. Simonson MS: Endothelins: Multifunctional renal peptides. Physiol Rev 73:375-411, 1993
4. Inoue A, Yanagisawa M, Takuwa Y, Mitsui Y, Kobayashi M, Masaki T: The human preproendothelin-1 gene. J Biol Chem 264:14954-14959, 1989
5. Masaki T, Kimura S, Yanagisawa M, Goto K: Molecular and cellular mechanism of endothelin regulation. Implications for vascular function. Circulation 84:1457-1468, 1991
6. Emoto N, Yanagisawa M: Endothelin-converting enzyme-2 is a membrane-bound phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem 270:15262-15268, 1995
7. Xu D, Emoto N, Giaid A, Glaughter C, Kaw S, deWit D, Yanagisawa M: ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78:473-485, 1994
8. Harrison VJ, Barnes K, Turner AJ, Wood E, Corder R, Vane JR: Identification of endothelin 1 and big endothelin 1 in secretory vesicles isolated from bovine aortic endothelial cells. Proc Natl Acad Sci U S A 92:6344-6348, 1995
9. Fujita K, Matsumura Y, Kita S, Hisaki K, Takaoka M, Morimoto S: Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney. Hypertension 24:227-233, 1994
10. Hoffman A, Haramati A, Kalai I, Shuranyi E, Winaver J: Diuretic-natriuretic actions and pressor effects of big-endothelin (1-39) in phosphoramidon-treated rats. Proc Soc Exp Biol Med 205:168-173, 1994
11. Fukuroda T, Fujikawa T, Ozaki S, Ishikawa K, Yano M, Nishikibe M: Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem Biophys Res Commun 199:1461-1465, 1994
12. Beutler B, Cerami A: Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature 320:584-588, 1986
13. Edano T, Arai K, Ohshima T, Koshi T, Hirata M, Ohkuchi M, Okabe T: Purification and characterization of endothelin-1 degradation activity from porcine kidney. Biol Pharm Bull 17:379-382, 1994
14. Deng AY, Martin LL, Balwierczak JL, Jeng AY: Purification and characterization of an endothelin degradation enzyme from rat kidney. J Biochem 115:120-125, 1994
15. Janas J, Sitkiewicz D, Warnawin K, Janas RM: Characterization of a novel, high-molecular weight, acidic, endothelin-1 inactivating metalloendopeptidase from the rat kidney. J Hypertens 12:1155-1162, 1994
16. Itoh K, Kase R, Shimmoto M, Satake A, Sakuraba H, Suzuki Y: Protective protein as an endogenous endothelin degradation enzyme in human tissues. J Biol Chem 270:515-518, 1995
17. Abassi ZA, Tate JE, Golomb E, Keiser HR: Role of neutral endopeptidase in the metabolism of endothelin. Hypertension 20:89-95, 1992
18. Hosoda K, Nakao K, Tamura N, Arai H, Ogawa Y, Suga S, Nakanishi S, Imura H: Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor. J Biol Chem 267:18797-18804, 1992
19. B endothelin receptor. Biochem Biophys Res Commun 178:656-663, 1991
20. Shyamala V, Moulthrop THM, Stratton-Thomas J, Tekamp-Olson P: Two distinct human endothelin B receptors generated by alternative splicing from a single gene. Cell Mol Biol Res 40:285-296, 1994
21. Kumar C, Mwangi V, Nuthulaganti P, Wu H, Pullen M, Brun K, Aiyar H, Morris RA, Naughton R, Nambi P: Cloning and characterization of a novel endothelin receptor from Xenopus heart. J Biol Chem 269:13414-13420, 1994
22. Chun M, Lin HY, Henis YI, Lodish HF: Endothelin-induced endocytosis of cell surface ETA receptors. J Biol Chem 270:10855-10860, 1995
23. Pernow J, Franco-Cereceda A, Matran R, Lundberg JM: Effect of endothelin-1 on regional vascular resistances in the pig. J Cardiovasc Pharmacol 13:S205-S206, 1989 (suppl 5)
24. Madeddu P, Troffa C, Glorioso N, Pazzola A, Soro A, Manunta P, Tonolo G, Demontis MP, Varoni MV, Anania V: Effect of endothelin on regional hemodynamics and renal function in awake normotensive rats. J Cardiovasc Pharmacol 14:818-825, 1989
25. Tasaka K, Kitazumi K: The control of endothelin-1 secretion. Gen Pharmacol 25:1059-1069, 1994
26. Fukunaga M, Yura T, Badr KF: Stimulatory effect of 8-epi-PGF2α, an F2-isoprostane, on endothelin-1 release. J Cardiol Pharmacol 26:S51-S52, 1995
27. Carlini R, Dusso A, Obialo C, Alvarez UM, Rothstein M: Recombinant human erythropoietin increases endothelin-1 release by endothelial cells. Kidney Int 43:1010-1014, 1993
28. López-Ongil S, Saura M, Lamas S, Rodriguez-Puyol M, Rodriguez-Puyol D: Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric oxide synthase in vascular endothelial cells. Exp Nephrol 4:37-42, 1996
29. Lee M-U, Temizer DH, Clifford JA, Quertermous T: Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. J Biol Chem 266:16188-16192, 1991
30. Wang DL, Wung B, Peng Y, Wang JJ: Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cells. J Cell Physiol 163:400-406, 1995
31. Hishikawa K, Nakaki T, Marumo T, Suzuki H, Kato R, Saruta T: Pressure enhances endothelin-1 release from cultured human endothelial cells. Hypertension 25:449-452, 1995
32. Kuchan MJ, Frangos JA: Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am J Physiol 264:H150-H156, 1993
33. Morita T, Kurihara H, Maemura K, Yoshizumi M, Yazaki Y: Disruption of cytoskeletal structures mediates shear stress-induced endothelin-1 gene expression in cultured porcine aortic endothelial cells. J Clin Invest 92:1706-1712, 1993
34. Kohan DE: Endothelins in the kidney: Physiology and pathophysiology. Am J Kidney Dis 22:493-510, 1993
35. Prins BA, Hu R-M, Nazario B, Pedram A, Frank HJL, Weber MA, Levin ER: Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells. J Biol Chem 269:11938-11944, 1994
36. Yokokawa K, Tahara H, Kohno M, Mandal AK, Yanagisawa M, Takeda T: Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells. J Clin Invest 92:2080-2085, 1993
37. Momose N, Fukuo K, Morimoto S, Ogihara T: Captopril inhibits endothelin-1 secretion from endothelial cells through bradykinin. Hypertension 21:921-924, 1993
38. Fujitani Y, Oda K, Takimoto M, Inui T, Okada T, Urade Y: Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein. FEBS Lett 298:79-83, 1992
39. Filep JG, Battistini B, Cote YP, Beaudoin AR, Sirois P: Endothelin-1 induces prostacyclin release from bovine aortic endothelial cells. Biochem Biophys Res Commun 177:171-176, 1991
40. De Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR: Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci U S A 85:9797-9800, 1988
41. Clark KL, Pierre L: Characterization of endothelin receptors in rat renal artery in vitro. Br J Pharmacol 114:785-790, 1995
42. DeLeon H, Garcia R: Characterization of endothelin receptor subtypes in isolated rat renal preglomerular microvessels. Regul Pept 60:1-8, 1995
43. 125I-endothelin-1 binding to rat and rabbit renal microvasculature. J Pharmacol Exp Ther 274:1064-1089, 1995
44. A receptor-mediated responses to endothelin-1 and big endothelin-1 in the rat kidney. Br J Pharmacol 111:729-732, 1994
45. B receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney. Br J Pharmacol 111:515-520, 1994
46. Brooks DP, DePalma PD, Pullen M, Nambi P: Characterization of canine renal endothelin receptor subtypes and their function. J Pharmacol Exp Ther 268:1091-1097, 1994
47. Clavell AL, Stingo AJ, Margulies KB, Brandt RR, Burnett JC Jr: Role of endothelin receptor subtypes in the in vivo regulation of renal function. Am J Physiol 268:F455-F460, 1995
48. 125I]-PD151242: A selective ligand for endothelin ETA receptors in human kidney which localizes to renal vasculature. Br J Pharmacol 113:1303-1310, 1994
49. Kaasjager HAH, Shaw S, Koomans HA, Rabelink AJ: Systemic and renal effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) in humans. J Am Soc Nephrol 6:661, 1995 (abstr)
50. Maguire JJ, Kuc RE, O'Reilly G, Davenport AP: Vasoconstrictor endothelin receptors characterized in human renal artery and vein in vitro. Br J Pharmacol 113:49-54, 1994
51. King AJ, Brenner BM, Anderson S: Endothelin: A potent renal and systemic vasoconstrictor peptide. Am J Physiol 256:F1051-F1058, 1989
52. Saito M, Homma S, Yamatsu I, Sato M, Ohshima N: Visualization of renal microcirculation in isolated Munich-Wistar rat kidneys: Effects of endothelin-1 on renal hemodynamic activity. Jpn J Pharmacol 66:221-229, 1994
53. Bloom ITM, Bentley FR, Wilson MA, Garrison RN: In vivo effects of endothelin on the renal microcirculation. J Surg Res 54:274-280, 1993
54. Cavarape A, Bartoli E: Visualization of effects of ETA receptor blockade with BQ-123 on renal hemodynamics in the split hydronephrotic kidney of rats. J Am Soc Nephrol 6:656, 1995
55. 2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat. J Clin Invest 95:2734-2740, 1995
56. Montañés I, Flores O, Eleno N, Lopez-Novoa JM: Effects of a new dihydropyridine derivative, S12968 (pranedipine), and its stereoisomer, S12967, on renal effects of endothelin-1. Can J Physiol Pharmacol 72:1294-1298, 1994
57. Takenaka T, Forster H, Epstein M: Protein kinase C and calcium channel activation as determinants of renal vasoconstriction by angiotensin II and endothelin. Circ Res 73:743-750, 1993
58. Takahashi K, Katoh T, Fukunaga M, Badr KF: Studies on the glomerular microcirculatory actions of manidipine and its modulation of the systemic and renal effects of endothelin. Am Heart J 125:609-619, 1993
59. Rabelink TJ, Kaasiager KAH, Boer P, Stroes EG, Braam B, Koomans HA: Effects of endothelin-1 on renal function in humans: Implications for physiology and pathophysiology. Kidney Int 46:376-381, 1994
60. Kaasjager KAH, van Rijn HJM, Koomans HA, Rabelink TJ: Interactions of nifedipine with the renovascular effects of endothelin in humans. J Pharmacol Exp Ther 275:306-311, 1995
61. Gordienko DV, Clausen C, Goligorsky MS: Ionic currents and endothelin signaling in smooth muscle cells from rat renal resistance arteries. Am J Physiol 266:F325-F341, 1994
62. 2 from the guinea pig lung and nitric oxide from the rabbit kidney by a selective ETB receptor antagonist, BQ-788. Br J Pharmacol 113:1257-1262, 1994
63. Ercan ZS, Türker RK, Uluoglu C, Yazar Ö, Zengil H: The effects of endothelin peptides in the rabbit isolated perfused kidney. Gen Pharmacol 25:1471-1476, 1994
64. Rubinstein I, Gurbanov K, Hoffman A, Better OS, Winaver J: Differential effect of endothelin-1 on renal regional blood flow: Role of nitric oxide. J Cardiovasc Pharmacol 26:S208-S210, 1995
65. Bijlsma JA, Rabelink AJ, Kaasjager KAH, Koomans HA: L-arginine does not prevent the renal effects of endothelin in humans. J Am Soc Nephrol 5:1508-1516, 1995
66. Hollenberg SM, Tong W, Shelhamer JH, Lawrence M, Cunnion RE: Eicosanoid production by human aortic endothelial cells in response to endothelin. Am J Physiol 267:H2290-H2296, 1994
67. Hunger KA, Takahashi K, Awazu M, Frazer M, Falk SA, Conger JD, Badr KF: Maintenance of endothelin-induced renal arteriolar constriction in rats is cyclooxygenase dependent. Am J Physiol 264:F637-F644, 1993
68. Trybulec M, Dude RR, Gryglewski RJ: Effects of endothelin-1 and endothelin-3 on the release of prostanoids from isolated perfused rat kidney. J Cardiovasc Pharmacol 17:5229-8232, 1991 (suppl 7)
69. Miura K, Yukimura T, Yamashita Y, Shimmen T, Okumura M, Yamanaka S, Imanishi M, Yamamoto K: Renal and femoral vascular responses to endothelin-1 in dogs: Role of prostaglandins. J Pharmacol Exp Ther 256:11-17, 1991
70. Ritthaler T, Scholz H, Ackermann M, Riegger G, Kurtz A, Kramer BK: Effects of endothelins on renin secretion from isolated mouse renal juxtaglomerular cells. Am J Physiol 268:F39-F45, 1995
71. Scholz H, Kramer BK, Hamann M, Gotz KH, Kurtz A: Effects of endothelins on renin secretion from rat kidneys. Acta Physiol Scand 155:173-182, 1995
72. Naess PA, Christensen G, Kiil F: Inhibitory effect of endothelin on renin release in dog kidneys. Acta Physiol Scand 148:131-136, 1993
73. Lin H, Sangmal M, Smith MJ Jr, Young DB: Effect of endothelin-1 on glomerular hydraulic pressure and renin release in dogs. Hypertension 21:845-851, 1993
74. Chan DP, Clavell A, Keiser J, Burnett JC Jr: Effects of renin-angiotensin system in mediating endothelin-induced renal vasoconstriction: Therapeutic implications. J Hypertension 12:S45-S49, 1994
75. Cao L, Banks RO: Cardiorenal actions of endothelin, part I: Effects of converting enzyme inhibition. Life Sci 46:577-583, 1990
76. Wilkins FC Jr, Kassab S, Kato T, Mizelle HL, Opgenorth TJ, Granger JP: Chronic endothelin-induced pressor and renal actions in conscious dogs do not require altered ANG II formation. Am J Physiol 268:R395-R402, 1995
77. Wilkins FC Jr, Alberola A, Mizelle HL, Opgenorth TJ, Granger JP: Systemic hemodynamics and renal function during long-term pathophysiological increases in circulating endothelin. Am J Physiol 268:R375-R381, 1995
78. Schricker K, Scholz H, Hamann M, Clozel M, Krämer BK, Kurtz A: Role of endogenous endothelins in the renin system of normal and two-kidney one clip rats. Hypertension 26:1025-1029, 1995
79. Kohan DE: Production of endothelin-1 by rat mesangial cells: Regulation by tumor necrosis factor. J Lab Clin Med 119:477-484, 1992
80. Iwasaki S, Homma T, Matsuda Y, Kon V: Endothelin receptor subtype B mediates autoinduction of endothelin-1 in rat mesangial cells. J Biol Chem 270:6997-7003, 1995
81. Owada A, Tomita K, Terada Y, Sakamoto H, Nonguchi H, Maramo F: Endothelin (ET)-3 stimulates cyclic guanosine 3′,5′-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. J Clin Invest 93:556-563, 1994
82. Martin ER, Brenner BM, Ballermann BJ: Heterogeneity of cell surface endothelin receptors. J Biol Chem 265:14044-14049, 1990
83. Simonson MS, Rooney A: Characterization of endothelin receptors in mesangial cells: Evidence for two functionally distinct endothelin binding sites. Mol Pharmacol 46:41-50, 1994
84. Simonson MS, Wann S, Mene P, Dubyak GR, Kester M, Nakazato Y, Sedor JR, Dunn MJ: Endothelin stimulates phospholipase C, Na/H exchange, c-fos expression, and mitogenesis in rat mesangial cells. J Clin Invest 83:708-712, 1989
85. Thomas CP, Baldi E, Simonson MS, Kester M, Dunn MJ: Endothelin receptors and coupled GTP-binding proteins in glomerular mesangial cells. J Cardiovasc Pharmacol 17:S79-S84, 1991 (suppl 7)
86. 2 synthesis in mesangial cells cocultured with glomerular endothelial cells. Am J Physiol 263:C200-C209, 1992
87. Bakris GL, Re RN: Endothelin modulates angiotensin II-induced mitogenesis of human mesangial cells. Am J Physiol 264:F937-F942, 1993
88. Kohno M, Horio T, Yokokawa K, Yasunari K, Kurihara N, Takeda T: Endothelin modulates the mitogenic effect of PDGF on glomerular mesangial cells. Am J Physiol 266:F894-F900, 1994
89. Nitta K, Uchida K, Kimata N, Kawashima A, Yumura W, Nihei H: Endothelin-1 mediates erythropoietin-stimulated glomerular endothelial cell-dependent proliferation of mesangial cells. Eur J Pharmacol 293:491-494, 1995
90. A. J Am Soc Nephrol 5:1074-1080, 1994
91. Simonson MS, Herman WH: Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. J Biol Chem 268:9347-9357, 1993
92. Baldi E, Musial A, Kester M: Endothelin stimulates phosphatidylcholine hydrolysis through both PLC and PLD pathways in mesangial cells. Am J Physiol 266:F957-F965, 1994
93. Schramek H, Sorokin A, Watson RD, Dunn MJ: Differential long-term regulation of MEK and of p42 MAPK in rat glomerular mesangial cells. Am J Physiol 270:C40-C48, 1996
94. Beck K-F, Mohaupt MG, Sterzel RB: Endothelin-1 inhibits cytokine-stimulated transcription of inducible nitric oxide synthase in glomerular mesangial cells. Kidney Int 48:1893-1899, 1995
95. Mattana J, Singhal PC: L-arginine supplementation antagonizes the effects of angiotensin II and endothelin 1 on mesangial cell proliferation. Cell Physiol Biochem 5:176-192, 1995
96. Hughes AK, Padilla E, Kutchera WA, Michael JR, Kohan DE: Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells. Kidney Int 47:53-61, 1995
97. Kester M, Coroneos E, Thomas PJ, Dunn MJ: Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells. J Biol Chem 269:22574-22580, 1994
98. Rúiz-Ortega M, Gómez-Garre D, Alcázar R, Palacios I, Bustos C, González S, Plaza JJ, González E, Egido J: Involvement of angiotensin II and endothelin in matrix protein production and renal sclerosis. J Hypertens 12:551-558, 1994
99. Josepevitz C, Nord EP: Endothelin stimulates tyrosine phosphorylation of focal adhesion kinase and association with paxillin in mesangial cells. J Am Soc Nephrol 6:795, 1995 (abstr)
100. Cybulsky AV, Stewart DJ, Cybulsky MI: Glomerular epithelial cells produce endothelin-1. J Am Soc Nephrol 3:1398-1404, 1993
101. Rebibou JM, He CJ, Delarue F, Peraldi MN, Adida C, Rondeau E, Sraer JD: Functional endothelin-1 receptors on human glomerular podocytes and mesangial cells. Nephrol Dial Transplant 7:288-292, 1992
102. Ujiie K, Terada Y, Nonoguchi H, Shinohara M, Tomita K, Marumo F: Messenger RNA expression and synthesis of endothelin-1 along rat nephron segments. J Clin Invest 90:1043-1048, 1992
103. Uchida S, Takemoto F, Ogata E, Kurokawa K: Detection of endothelin-1 mRNA by RT-PCR in isolated rat renal tubules. Biochem Biophys Res Commun 188:108-113, 1992
104. Kohan DE: Endothelin synthesis by rabbit renal tubule cells. Am J Physiol 261:F221-F226, 1991
105. Chen M, Todd-Turla K, Wang W, Cao X, Smart A, Brosius FC, Killen PD, Keiser JA, Briggs JP, Schnermann J: Endothelin-1 mRNA in glomerular and epithelial cells of kidney. Am J Physiol 265:F542-F550, 1993
106. Pupilli C, Brunori M, Misciglia N, Selli C, Ianni L, Yanagisawa M, Mannelli M, Serio M: Presence and distribution of endothelin-1 gene expression in human kidney. Am J Physiol 267:F679-F687, 1994
107. Ong ACM, Jowett TP, Firth JD, Burton S, Karet FE, Fine LG: An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney Int 48:390-401, 1995
108. Terada Y, Tomita K, Nonoguchi H, Yang T, Marumo F: Expression of endothelin-3 mRNA along rat nephron segments using polymerase chain reaction. Kidney Int 44:1273-1280, 1993
109. 125I-endothelin-1,-2,-3 binding sites in the human kidney. Eur J Pharmacol 176:233-236, 1990
110. Terada Y, Tomita K, Nonoguchi H, Marumo F: Different localization of two types of endothelin receptor mRNA in microdissected rat nephron segments using reverse transcription and polymerase chain reaction assay. J Clin Invest 90:107-112, 1992
111. Takemoto F, Uchida S, Ogata E, Kurokawa K: Endothelin-1 and endothelin-3 binding to rat nephrons. Am J Physiol 264:F827-F832, 1993
112. Chow LH, Subramanian S, Nuovo GJ, Miller F, Nord EP: Endothelin receptor mRNA expression in renal medulla identified by in situ PT-PCR. Am J Physiol 269:F449-F457, 1995
113. Karet FE, Kuc RE, Davenport AP: Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney. Kidney Int 44:36-42, 1993
114. B receptor. J Pharmacol Exp Ther 267:1028-1033, 1993
115. Kohan DE, Padilla E, Hughes AK: Endothelin B receptor mediates ET-1 effects on cAMP and PGE2 accumulation in rat IMCD. Am J Physiol 265:F670-F676, 1993
116. Ominato M, Satoh T, Katz AI: Endothelins inhibit Na-K-ATPase activity in proximal tubules: Studies of mechanisms. J Am Soc Nephrol 5:588, 1994 (abstr)
117. Kamphuis C, Yates NA, McDaugall JG: Differential blockade of the renal vasoconstrictor and diuretic responses to endothelin-1 by endothelin antagonist. Clin Exp Pharmacol Physiol 21:329-333, 1994
118. B receptor agonist, IRL1620. Eur J Pharmacol 264:399-405, 1994
119. Kohan DE, Hughes AK, Perkins SP: Characterization of endothelin receptors in the inner medullary collecting duct of the rat. J Biol Chem 267:12336-12340, 1992
120. Cernacek P, Legault L, Stewart DJ, Levy M: Specific endothelin binding sites in renal medullary collecting duct cells: Lack of interaction with ANP binding and cGMP signalling. Can J Physiol Pharmacol 70:1167-1174, 1992
121. Gallego MS, Ling BN: Regulation of amiloride-sensitive sodium channels by endothelin-1 in distal nephron cells. Am J Physiol (in press)
122. Denton KM, Anderson WP: Vascular actions of endothelin in the rabbit kidney. Clin Exp Pharmacol Physiol 17:861-872, 1990
123. Schramek H, Willinger CC, Gstraunthaler G, Pfaller W: Endothelin-3 modulates glomerular filtration rate in the isolated perfused rat kidney. Renal Physiol Biochem 15:325-333, 1992
124. Schnermann J, Lorenz JN, Briggs JP, Keiser JA: Induction of water diuresis by endothelin in rats. Am J Physiol 263:F516-F526, 1992
125. + ATPase activity in the rat proximal straight tubule. J Am Soc Nephrol 2:976-982, 1991
126. 1 cells. J Pharmacol Exp Ther 270:1035-1040, 1994
127. 1 porcine kidney epithelial cells via formation of an endothelium-derived relaxing factor-like substance. J Pharmacol Exp Ther 259:1102-1108, 1991
128. - transporters in rabbit renal cortex. Kidney Int 42:18-24, 1992
129. + exchange. Am J Physiol 266:F658-F666, 1994
130. Chu T-S, Peng Y, Cano A, Yanagisawa M, Alpern RJ: Endothelin B receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells. J Clin Invest 97:1454-1462, 1996
131. Garcia NH, Garvin JL: Endothelin's biphasic effect on fluid absorption in the proximal straight tubule. J Clin Invest 93:2572-2577, 1994
132. Perico N, Cornejo RP, Benigni A, Malanchini B, Ladny JR, Remuzzi G: Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products. J Am Soc Nephrol 2:57-69, 1991
133. Tomita K, Nonguchi H, Terada Y, Marumo F: Effects of ET-1 on water and chloride transport in cortical collecting ducts of the rat. Am J Physiol 264:F690-F696, 1993
134. Tomita K, Nonoguchi H, Marumo F: Effects ofendothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat. J Clin Invest 85:2014-2018, 1990
135. Takemoto F, Uchida S, Katagirl H, Oka Y, Nakao A, Kurokawa K: Desensitization of endothelin-1 binding by vasopressin via a cAMP-mediated pathway in rat CCD. Am J Physiol 268:F385-F390, 1995
136. - channels in cultured rabbit CCT principal cells. J Am Soc Nephrol 5:292, 1994 (abstr)
137. Kurokawa K, Yoshitomi K, Ikeda M, Uchida S, Naruse M, Imai M: Regulation of cortical collecting duct function: Effect of endothelin. Am Heart J 125:582-588, 1993
138. Nadler SP, Zimplemann JA, Hebert RL: Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct. J Clin Invest 90:1458-1466, 1992
139. Kohan DE, Padilla E: Endothelin-1 is an autocrine factor in rat inner medullary collecting ducts. Am J Physiol 263:F607-F612, 1992
140. Kohan DE, Hughes AK: Autocrine role of endothelin in rat IMCD: Inhibition of AVP-induced cAMP accumulation. Am J Physiol 265:F126-F129, 1993
141. +-ATPase in intact tubular epithelial cells. Am J Physiol 257:C1101-C1107, 1989
142. Kohan DE, Padilla E: Endothelin-1 production by rat inner medullary collecting ducts: Effect of nitric oxide, cGMP, and immune cytokines. Am J Physiol 266:F291-F297, 1994
143. Zeiler M, Löffler B-M, Bock HA, Thiel G, Basel K: Water diuresis increases endothelin-1 excretion in humans. J Am Soc Nephrol 6:751, 1995 (abstr)
144. Worgall S, Manz F, Kleschin K, Feth F, Rascher W: Elevated urinary excretion of endothelin-like immunoreactivity in children with renal disease is related to urine flow rate. Clin Nephrol 41:331-337, 1994
145. Mattyus I, Zimmerhack LB, Schwarz A, Hentschel M, Brandis M, Milteny M, Tulassay T: Renal excretion of endothelin in children is influenced by age and diuresis. Acta Paediatr 83:468-472, 1994
146. Michel H, Bäcker A, Meyer-Lehnert H, Migas I, Kramer HJ: Rat renal, aortic and pulmonary endothelin-1 receptors: Effects of changes in sodium and water intake. Clin Sci 85:593-597, 1993
147. Kohan DE, Padilla E: Osmolar regulation of endothelin-1 production by rat inner medullary collecting duct. J Clin Invest 91:1235-1240, 1993
148. Serneri GGN, Modesti PA, Cecioni I, Biagini D, Migliorini A, Costoli A, Colella A, Naldoni A, Paoletti P: Plasma endothelin and renal endothelin are two distinct systems involved in volume homeostasis. Am J Physiol 268:H1829-H1837, 1995
149. Firth JD, Schricker K, Ratcliffe PJ, Kurtz A: Expression of endothelins 1 and 3 in the rat kidney. Am J Physiol 269:F522-F528, 1995
150. Schramek H, Gstraunthaler G, Willinger CC, Pfaller W: Hyperosmolality regulates endothelin release by Madin-Darby canine kidney cells. J Am Soc Nephrol 4:206-213, 1993
151. Schnermann J, Zhu X, Shu X, Pham H, Briggs J: Osmotic regulation of endothelin 1 expression in a cortical collecting duct cell line. J Am Soc Nephrol 6:746, 1995 (abstr)
152. Yang T, Terada Y, Nonoguchi H, Ujiie K, Tomita K, Marumo F: Effect of hyperosmolality on production and mRNA expression of endothelin-1 in inner medullary collecting ducts. J Am Soc Nephrol 3:449, 1992 (abstr)
153. Migas I, Bäcker A, Meyer-Lehnert H, Kramer HJ: Endothelin synthesis by porcine inner medullary collecting duct cells. Am J Hypertens 8:748-752, 1995
154. Nir A, Clavell AL, Heublein D, Aarhus LL, Burnett JC Jr: Acute hypoxia and endogenous renal endothelin. J Am Soc Nephrol 4:1920-1924, 1994
155. Ong ACM, Jowett TP, Firth JD, Burton S, Kitamura M, Fine LG: Human tubular-derived endothelin in the paracrine regulation of renal interstitial fibroblast function. Exp Nephrol 2:134, 1994 (abstr)
156. Zoja C, Morigi M, Figliuzzi M, Bruzzi I, Oldroyd S, Benigni A, Ronco P, Remuzzi G: Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins. Am J Kidney Dis 26:934-941, 1995
157. Ong ACM, Jowett TP, Moorhead JF, Owen JS: Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells. Kidney Int 46:1315-1321, 1994
158. Wilkes BM, Ruston AS, Mento P, Giraldi E, Hart D, Molen MV, Barnett R, Nord EP: Characterization of endothelin 1 receptor and signal transduction mechanisms in rat medullary interstitial cells. Am J Physiol 260:F579-F589, 1991
159. Hughes AK, Barry WH, Kohan DE: Identification of a contractile function for renal medullary interstitial cells. J Clin Invest 96:411-416, 1995
160. 2. J Am Soc Nephrol 5:592, 1994 (abstr)
161. Kon V, Yoshioka T, Fogo A, Ichikawa I: Glomerular actions of endothelin in vivo. J Clin Invest 83:1762-1767, 1989
162. Gellai M, Jugus M, Fletcher T, Nambi P, Ohlstein EH, Elliott JD, Brooks DP: Nonpeptide endothelin receptor antagonists V: Prevention and reversal of acute renal failure in the rat by SB 209670. J Pharmacol Exp Ther 275:200-206, 1995
163. Gellai M, Jugus M, Fletcher T, DeWolf R, Nambi P: Reversal of postischemic acute renal failure with a selective endothelin A receptor antagonist in the rat. J Clin Invest 93:900-906, 1994
164. Chan L, Chittinandana A, Shapiro JI, Shanley PF, Schrier RW: Effect of an endothelin-receptor antagonist on ischemic acute renal failure. Am J Physiol 266:F135-F138, 1994
165. Kusumoto K, Kubo K, Kandori H, Kitayoshi T, Sato S, Wakimasu M, Watanabe T, Fujino M: Effects of a new endothelin antagonist, TAK-044, on postischemic acute renal failure in rats. Life Sci 55:301-310, 1994
166. Brooks DP, DePalma PD, Gellai M, Nambi P, Ohlstein EH, Elliott JD, Gleason JG, Ruffolo RRJ: Nonpeptide endothelin receptor antagonists. III. Effects of SB 209670 and BQ123 on acute renal failure in anesthetized dogs. J Pharmacol Exp Ther 271:769-775, 1994
167. Krause SM, Walsh TF, Greenlee WJ, Ranaei R, Kivlighn SD: The endothelin antagonist, L-754,142, protects renal function following 60 minutes of aortic cross-clamping in the dog. J Am Soc Nephrol 6:983, 1995 (abstr)
168. Stingo AJ, Clavell AL, Aarhus LL, Burnett JC Jr: Biological role for the endothelin-A receptor in aortic cross-clamping. Hypertension 22:62-66, 1993
169. Nambi P, Pullen M, Jugus M, Gellai M: Rat kidney endothelin receptors in ischemia-induced acute renal failure. J Pharmacol Exp Ther 264:345-348, 1993
170. Firth JD, Ratcliffe PJ: Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression. J Clin Invest 90:1023-1031, 1992
171. Hughes AK, Stricklett PK, Padilla E, Kohan DE: Effect of reactive oxygen species on endothelin-1 production by human mesangial cells. Kidney Int 49:181-189, 1996
172. Kohno M, Yokokawa K, Mandal AK, Horio T, Yasunari K, Takeda T: Cardiac natriuretic peptides inhibit cyclosporine-induced production of endothelin in cultured rat mesangial cells. Metabolism 44:404-409, 1995
173. Goodall T, Kind CN, Hammond TG: FK506-induced endothelin release by cultured rat mesangial cells. J Cardiovasc Pharmacol 26:S482-S485, 1995 (suppl 3)
174. Langman LJ, Yatscoff RW: Comparison of the effects of cyclosporin G (OG37-325), cyclosporin A, and their metabolites on the release of endothelin and prostacyclin from primary renal and aortic endothelial cell lines. Ther Drug Monit 16:450-457, 1994
175. Iwasaki S, Homma T, Kon V: Site specific regulation in the kidney of endothelin and its receptor subtypes by cyclosporine. Kidney Int 45:592-597, 1994
176. Brooks DP, Contino LC: Prevention of cyclosporine A-induced renal vasoconstriction by the endothelin receptor antagonist SB 209670. Eur J Pharmacol 294:571-576, 1995
177. Conger JD, Kim GE, Robinette JB: Effects of ANG II, ETA, and TxA2 receptor antagonists on cyclosporin A renal vasoconstriction. Am J Physiol 267:F443-F449, 1994
178. Lanese DM, Conger JD: Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles. J Clin Invest 91:2144-2149, 1993
179. Kon V, Awazu M: Endothelin and cyclosporine nephrotoxicity. Ren Fail 14:345-350, 1992
180. Kon V, Hunley TE, Fogo A: Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis. Transplantation 60:89-95, 1995
181. Davis LS, Haleen SJ, Doherty AM, Cody WL, Keiser JA: Effects of selective endothelin antagonists on the hemodynamic response to cyclosporine A. J Am Soc Nephrol 4:1448-1454, 1994
182. Heyman SN, Clark BA, Cantley L, Spokes K, Rosen S, Brezis M, Epstein FH: Effects of ioversol versus iothalamate on endothelin release and radiocontrast nephropathy. Invest Radiol 28:313-318, 1993
183. Bird E, Giancarli M, Barton D, Durham S: Endothelin-A receptors mediate ET effects in radiocontrast nephropathy. J Am Soc Nephrol 6:994, 1995 (abstr)
184. Pollock DM, Polakowski JS: Beneficial effect of ETA receptor blockade in radiocontrast-induced nephropathy in the rat. J Am Soc Nephrol 6:667, 1995 (abstr)
185. Oldroyd S, Slee S, Haylor J, Morcos SK, Wilson C: Role for endothelin in the renal responses to radiocontrast media in the rat. Clin Sci 87:427-434, 1994
186. Oldroyd SD, Haylor JL, Morcos SK: Bosentan, an orally active endothelin antagonist: Effect on the renal response to contrast media. Radiology 196:661-665, 1995
187. Cantley LG, Spokes K, Clark B, McMahon EG, Carter J, Epstein FH: Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. Kidney Int 44:1217-1223, 1993
188. Russo D, Minutolo R, Cianciaruso B, Memoli B, Conte G, De Nicola L: Early effects of contrast media on renal hemodynamics and tubular function in chronic renal failure. J Am Soc Nephrol 6:1451-1458, 1995
189. Kaddoura S, Curzen NP, Evans TW, Firth J, Poole-Wilson PA: Tissue expression of endothelin-1 mRNA in endotoxaemia. Biochem Biophys Res Commun 218:641-647, 1996
190. Nambi P, Pullen M, Slivjak MJ, Ohlstein EH, Storer B, Smith EF III: Endotoxin-mediated changes in plasma endothelin concentrations, renal endothelin receptor and renal function. Pharmacology 48:147-156, 1994
191. Özsan K, Türker RK, Ercan ZS: Possible involvement of endothelin peptides and L-arginine-nitric oxide pathway on the effect of endotoxin in the rabbit isolated perfused kidney. Mediators of Inflamm 3:211-214, 1994
192. Morise Z, Ueda M, Aiura K, Endo M, Kitajima M: Pathophysiologic role of endothelin-1 in renal function in rats with endotoxin shock. Surgery 115:199-204, 1994
193. Kohan DE, Padilla EC, Siegler RL: Endothelin concentrations and endothelin stimulating activity in the plasma of children with post-diarrheal hemolytic uremic syndrome, in Karmali MA, Goglio AG (eds): Recent Advances in Verocytotoxin-Producing Escherichia coli Infections. Amsterdam, The Netherlands, Elsevier Science, 1994, pp 377-379
194. Halim A, Kanayama N, El Maradny E, Maehara K, Masahiko H, Terao T: Endothelin-1 increased immunoreactive von Willebrand factor in endothelial cells and induced microthrombosis in rats. Thromb Res 76:71-78, 1994
195. Schulz E, Ruschitzka F, Lueders S, Heydenbluth R, Schrader J, Müller GA: Effects of endothelin on hemodynamics, prostaglandins, blood coagulation and renal function. Kidney Int 47:795-801, 1995
196. Karam H, Braneval P, Clozel J, Löffler B, Bariéty J, Clozel M: Role of endothelin in acute renal failure due to rhabdomyolysis in rats. J Pharm Exp Ther 274:481-486, 1995
197. Yokoi Y, Nakamura S, Serizawa A, Nishiyama R, Nishiwaka Y, Baba S: The role of endothelin in the pathophysiology of renal impairment during acute liver rejection. Transplantation 58:144-148, 1994
198. Reyes AA, Klahr S: Renal function after release of ureteral obstruction: Role of endothelin and the renal artery endothelium. Kidney Int 42:632-638, 1992
199. Yoshimura A, Iwasaki S, Inui K, Ideura S, Koshikawa S, Yanagisawa M, Masaki T: Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat. Kidney Int 48:1290-1297, 1995
200. Murer L, Zacchello G, Basso G, Scarpa A, Montini G, Chiozza ML, Zacchello F: Immunohistochemical distribution of endothelin in biopsies of pediatric nephrotic syndrome. Am J Nephrol 14:157-161, 1994
201. Nakamura T, Ebihara I, Fukui M, Osada S, Tomino Y, Masaki T, Goto K, Furuichi Y, Koide H: Modulation of glomerular endothelin and endothelin receptor gene expression in aminonucleoside-induced nephrosis. J Am Soc Nephrol 5:1585-1590, 1995
202. Roccatello D, Mosso R, Ferro M, Polloni R, De Filippi PG, Quattrocchio G, Bancale E, Cesano G, Sena LM, Piccoli G: Urinary endothelin in glomerulonephritis patients with normal renal function. Clin Nephrol 41:323-330, 1994
203. Achmad T, Rao G: Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers. Biochem Biophys Res Commun 189:994-1000, 1992
204. Martin-Nizzard H, Houssaini H, Lestavel-Delattre S, Duriez P, Fruchart J: Modified low density lipoproteins activate human monocytes to secrete immunoreactive endothelin. FEBS Lett 293:127-130, 1991
205. Fukuda K, Okuda S, Tamaki K, Yanagida T, Ando T, Fujishima M: The role of endothelin-1 as a mitogen on experimental glomerulonephritis in rats. J Am Soc Nephrol 6:865, 1995 (abstr)
206. Nakamura T, Ebihara I, Tomino Y, Koide H: Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. Kidney Int 47:481-489, 1995
207. Nakamura T, Ebihara I, Fukui M, Osada S, Tomino Y, Masaki T, Goto K, Furuichi Y, Koide H: Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice. J Am Soc Nephrol 4:1064-1072, 1993
208. Nakamura T, Fukui M, Ebihara I, Osada S, Takahashi T, Tomino Y, Koide H: Effects of a low-protein diet on glomerular endothelin family gene expression in experimental focal glomerular sclerosis. Clin Sci 88:29-37, 1995
209. Morabito E, Corsico N, Serafini S, Martelli EA: Elevated urinary excretion of endothelins in streptozotocin diabetic rats. Life Sci 54:197-200, 1994
210. Fukui M, Nakamura T, Ebihara I, Osada S, Tomino Y, Masaki T, Goto K, Furuichi Y, Koide H: Gene expression for endothelins and their receptors in glomeruli of diabetic rats. J Lab Clin Med 122:149-156, 1993
211. Fukui M, Nakamura T, Ebihara I, Makita Y, Osada S, Tomino Y, Koide H: Effects of enalapril on endothelin-1 and growth factor gene expression in diabetic rat glomeruli. J Lab Clin Med 123:763-768, 1994
212. Nakamura T, Ebihara I, Fukui M, Tomino Y, Koide H: Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix components and growth factors in diabetic glomeruli. Diabetes 44:895-899, 1995
213. Takahashi K, Sone M, Totsune K, Satoh F, Murakami O, Ohneda M, Mouri T: Immunoreactive endothelin in the human kidney: Comparison with natriuretic peptides. J Cardiovasc Pharmacol 26:5510-8512, 1995 (suppl 3)
214. Takeda M, Komeyama T, Tsutsui T, Mizusawa T, Katayama Y, Go H, Tamaki M, Hatano A: Changes in urinary excretion of endothelin-1-like immunoreactivity before and after unilateral nephrectomy in humans. Nephron 67:180-184, 1994
215. Orisio S, Benigni A, Bruzzi I, Corna D, Perico N, Zoja C, Benatti L, Remuzzi G: Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. Kidney Int 43:354-358, 1993
216. Torralbo A, Trobo JI, Borque M, Herrero JA, Velasco E, Marcello M, Gonzalez-Mate A, Barrientos A: Alterations in renal endothelin production in rats with reduced renal mass. Am J Kidney Dis 25:918-923, 1995
217. Benigni A, Zoja C, Corna D, Orisio S, Longaretti L, Bertani T, Remuzzi G: A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression. Kidney Int 44:440-444, 1993
218. Okada M, Kobayashi M, Maruyama H, Takahashi R, Ikemoto F, Yano M, Nishikibe M: Effects of a selective endothelin A-receptor antagonist, BQ-123, in salt-loaded stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 22:763-768, 1995
219. Markewitz BA, Kohan DE: Role of intrarenal endothelin in the generation and maintenance of hypertension. Miner Electrolyte Metab 21:342-352, 1995
220. Schiffrin EL: Endothelin: Potential role in hypertension and vascular hypertrophy. Hypertension 25:1135-1143, 1995
221. Gellai M, DeWolf R, Pullen M, Nambi P: Distribution and functional role of renal ET receptor subtypes in normotensive and hypertensive rats. Kidney Int 46:1287-1294, 1994
222. B receptors mediate contraction to endothelin-1 in renal artery of aging SHR rats. Hypertension 25:501-506, 1995
223. Shan-yan L, Hui C, Qin-yan G, Zao-chen Y, Jianghua Z, Ding Z, Zhao-kang Z: Role of endothelin in the pathogenesis of hypertension in spontaneously hypertensive and 2 kidneys-1 clip rats. Chin Med J (Engl) 103:748-753, 1990
224. Tomobe Y, Miyauchi T, Saito A, Yanagisawa M, Kimura S, Goto K, Masaki T: Effects of endothelin on the renal artery from spontaneously hypertensive and Wister Kyoto rats. Eur J Pharmacol 152:373-374, 1988
225. Evangelista S, Maggi CA, Castellucci A: Effect of endothelin (ET)-1, ET-3, and ET-(16-21) on the isolated and perfused rat kidney from normotensive and spontaneously hypertensive rats. Jpn J Pharmacol 59:239-241, 1992
226. Hirata Y, Matsuoka H, Kimura K, Fukui K, Hayakawa H, Suzuki E, Sugimoto T, Yanagisawa M, Masaki T: Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats. Circ Res 65:1370-1379, 1989
227. Hirata Y, Hayakawa H, Suzuki E, Omata M: Does endothelin work as an intrarenal mechanism to alter pressure natriuresis in spontaneously hypertensive rats? J Hypertens 12:251-257, 1994
228. Wright CE, Fozard JR: Differences in regional vascular sensitivity to endothelin-1 between spontaneously hypertensive and normotensive Wistar-Kyoto rats. Br J Pharmacol 100:107-113, 1990
229. Goligorsky MS, Iijima K, Morgan M, Yanagisawa M, Masaki T, Lin L, Nasjletti A, Kaskel F, Frazer M, Badr KF: Role of endothelin in the development of Dahl hypertension. J Cardiovasc Pharmacol 17:8484-8491, 1991 (suppl 7)
230. A receptor-mediated role of endothelin in the kidney of DOCA-salt hypertensive rats. Life Sci 58:1-7, 1996
231. Whitworth CE, Veniant MM, Firth JD, Cumming AD, Mullins JJ: Endothelin in the kidney in malignant phase hypertension. Hypertension 26:925-931, 1995
232. A receptor in the maintenance of deoxycorticosterone acetate-salt-induced hypertension. Br J Pharmacol 114:925-930, 1995
233. Bolger GT, Liard F, Jodoin A, Jaramillo J: Vascular reactivity, tissue levels, and binding sites for endothelin: A comparison in the spontaneously hypertensive and Wistar-Kyoto rats. Can J Physiol Pharmacol 69:406-413, 1991
234. Ohno A, Naruse M, Kato S, Hosaka M, Naruse K, Demura H, Sugino N: Endothelin-specific antibodies decrease blood pressure and increase glomerular filtration rate and renal plasma flow in spontaneously hypertensive rats. J Hypertens 10:781-785, 1992
235. Hocher B, Rohmeiss P, Zart R, Diekmann F, Vogt V, Metz D, Fakhury M, Gretz N, Bauer C, Koppenhagen K, Distler A: Significance of endothelin receptor subtypes in the kidneys of spontaneously hypertensive rats: Renal and hemodynamic effects of endothelin receptor antagonists. J Cardiovasc Pharmacol 26:8470-8472, 1995
236. Kato T, Kassab S, Wilkins FC Jr, Kirchner KA, Keiser J, Granger JP: Endothelin antagonists improve renal function in spontaneously hypertensive rats. Hypertension 25:883-887, 1995
237. Hoffman A, Grossman E, Goldstein DS, Gill JRJ, Keiser HR: Urinary excretion rate of endothelin-1 in patients with essential hypertension and salt sensitivity. Kidney Int 45:556-560, 1994
238. Kitamura K, Tanaka T, Kato J, Qgawa Y, Eto T, Tanaka K: Immunoreactive endothelin in rat kidney inner medulla: Marked decrease in spontaneously hypertensive rats. Biochem Biophys Res Commun 162:38-44, 1989
239. Hughes AK, Cline RC, Kohan DE: Alterations in renal endothelin production in the spontaneously hypertensive rat. Hypertension 20:666-673, 1992
240. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T, Cao W, Kamada N, Hishage K, Ouchi Y, Azuma S, Toyada Y, Ishikawa T, Kumada M, Yazaki Y: Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 368:703-710, 1994
241. Hoffman A, Grossman E, Abassi ZA, Keiser HR: Renal endothelin and hypertension. Nature 372:50, 1994
242. Maemura K, Kurihara Y, Morita H, Kurihara H, Yazaki Y: Renal endothelin and hypertension. Nature 372:50, 1994
243. Kurihara Y, Kurihara H, Oda H, Maemura K, Nagai R, Ishikawa T, Yazaki Y: Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 96:293-300, 1995
244. Hosoda K, Hammer RE, Richardson JA, Baynash AG, Cheung JC, Giaid A, Yanagisawa M: Targeted and natural (Piebald-Lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 80:1267-1276, 1994
245. Baynash AG, Hosoda K, Giald A, Richardson JA, Emoto N, Hammer RE, Yanagisawa M: Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 79:1277-1285, 1994
246. Deray G, Carayon A, Maistre G, Benhmida M, Masson F, Barthelemy C, Petitclerc T, Jacobs C: Endothelin in chronic renal failure. Nephrol Dial Transplant 7:300-305, 1992
247. Mallamaci F, Parlongo S, Zoccali C: Influence of cardiovascular damage and residual renal function on plasma endothelin in chronic renal failure. Nephron 63:291-295, 1993
248. Predel H-G, Meyer-Lehner H, Backer A, Stelkens H, Kramer HJ: Plasma concentrations of endothelin in patients with abnormal vascular reactivity. Life Sci 47:1837-1843, 1990
249. Saito Y, Kazuwa N, Shirakami G, Mukoyama M, Arai H, Hosoda K, Suga S, Ogawa Y, Imura H: Endothelin in patients with chronic renal failure. J Cardiovasc Pharmacol 17:S437-S439, 1991 (suppl 7)
250. Stockenhuber F, Gottsauner-Wolf M, Marosi L, Liegisch B, Kurz RW, Balcke P: Plasma levels of endothelin in chronic renal failure and after renal transplantation: Impact on hypertension and cyclosporin A-associated nephrotoxicity. Clin Sci 82:255-258, 1992
251. Warrens AN, Cassidy MJD, Takahashi K, Ghatei MA, Bloom SR: Endothelin in renal failure. Nephrol Dial Transplant 5:418-422, 1990
252. Lebel M, Grose JH, Kingma I, Langlois S: Plasma endothelin levels and blood pressure in hemodialysis and in CAPD patients. Effect of subcutaneous erythropoietin replacement therapy. Clin Exp Hypertens 16:565-575, 1994
253. Shichiri M, Hirata Y, Ando K, Emori T, Ohta K, Kimoto S, Ogura M, Inoue A, Maramo F: Plasma endothelin levels in hypertension and chronic renal failure. Hypertension 15:493-496, 1990
254. Kohno M, Murakawa K, Yasunari K, Yokokawa K, Horio T, Kurihara N, Takeda T: Prolonged blood pressure elevation after endothelin administration in bilaterally nephrectomized rats. Metabolism 38:712-713, 1989
255. Niwa T, Fujishiro T, Uema K, Tsuzuki T, Tominaga Y, Emoto Y, Miyazaki T, Maeda K: Effect of hemodialysis on plasma levels of vasoactive peptides: Endothelin, calcitonin gene-related peptide and human atrial natriuretic peptide. Nephron 64:552-559, 1993
256. Ross RD, Kalidindi V, Vincent JA, Kassab J, Dabbagh S, Hsu JM, Pinsky WW: Acute changes in endothelin-1 after hemodialysis for chronic renal failure. J Pediatr 122:874-876, 1993
257. Clozel M, Breu V, Gray GA, Kalina B, Löffler B-M, Burri K, Cassal J-M, Hirth G, Müller M, Neidhart W, Ramuz H: Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharm Exp Ther 270:228-235, 1994
258. Ohlstein EH, Nambi P, Douglas SA, Edwards RM, Gellai M, Lago A, Lever JD, Cousins RD, Gao A, Frazee JS, Peishoff CE, Bean JW, Eggleston DS, Elshourbagy NA, Kumar C, Lee JA, Yue T, Louden C, Brooks DP, Weinstock J, Feuerstein G, Poste G, Ruffulo RR, Gleason JG, Elliott JD: SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc Natl Acad Sci U S A 91:8052-8056, 1994
259. Stein PD, Hunt JT, Floyd DM, Moreland S, Dickinson KEJ, Mitchell C, Liu EC-K, Webb ML, Murugesan M, Dickey J, McMullen D, Zhang R, Lee VG, Serafino R, Delaney C, Schaeffer TR, Kozlowski M: The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-di-methyl-5-isoxazolyl)-1-naphthalenesulfonamide. J Med Chem 37:329-331, 1994
260. A) receptor-selective antagonists. J Med Chem 38:1259-1263, 1995