Conservation of the pyrrolnitrin biosynthetic gene cluster among six pyrrolnitrin-producing strains

FEMS Microbiology Letters

Volumn 180, Issue 1, 1999, Pages 39-44

  Hammer, Philip E ^a   Burd, Wassily ^b   Hill, D Steven ^a   Ligon, James M ^a   Van Pée, Karl Heinz ^c  

^a JEALOTT S HILL RESEARCH STATION   (United Kingdom)

^b GRODNO STATE MEDICAL UNIVERSITY   (Belarus)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Antibiotic; Halogenase; prnABCD gene; Pyrrolnitrin

Indexed keywords

PYRROLNITRIN;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; BURKHOLDERIA CEPACIA; GENE CLUSTER; GENE EXPRESSION; GENE SEQUENCE; MOLECULAR CLONING; MYXOCOCCALES; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PSEUDOMONAS FLUORESCENS;

ANTIBIOTICS, ANTIFUNGAL; BASE SEQUENCE; BLOTTING, SOUTHERN; BURKHOLDERIA CEPACIA; CONSERVED SEQUENCE; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTATION; MYXOCOCCUS; POLYMERASE CHAIN REACTION; PSEUDOMONAS; PYRROLNITRIN; SEQUENCE ALIGNMENT;

EID: 0032829244     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(99)00452-8     Document Type: Article

References (16)

1. Arima, K., Imanaka, H., Kousaka, M., Fukuda, A. and Tamura, G. (1964) Pyrrolnitrin, a new antibiotic substance, produced by Pseudomonas. Agric. Biol. Chem. 28, 575-576.
2. Homma, Y., Sato, Z., Hirayama, F., Konno, K., Shirahama, H. and Suzui, T. (1989) Production of antibiotics by Pseudomonas cepacia as an agent for biological control of soilborne plant pathogens. Soil Biol. Biochem. 21, 723-728.
3. Howell, C.R. and Stipanovic, R.D. (1979) Control of Rhizoctonia solani on cotton seedlings with Pseudomonas fluorescens and with an antibiotic produced by the bacterium. Phytopathology 77, 480-482.
4. Janisiewicz, W.J. and Roitman, J. (1988) Biological control of blue mold and grey mold on apple and pear with Pseudomonas cepacia. Phytopathology 78, 1697-1700.
5. Chernin, L., Brandis, A., Ismailov, Z. and Chet, I. (1996) Pyrrolnitrin production by an Enterobacter agglomerans strain with a broad spectrum of antagonistic activity towards fungal and bacterial phytopathogens. Curr. Microbiol. 32, 208-212.
6. Gerth, K., Trowitzsch, W., Wray, V., Höfle, G., Irschik, H. and Reichenbach, H. (1982) Pyrrolnitrin from Myxococcus fulvus (myxobacterales). J. Antibiot. 35, 1101-1103.
7. Kalbe, C., Marten, P. and Berg, G. (1996) Strains of the genus Serratia as beneficial rhizobacteria of oilseed rape with antifungal properties. Microbiol. Res. 151, 433-439.
8. Hammer, P.E., Hill, D.S., Lam, S.T., van Pée, K.-H. and Ligon, J.M. (1997) Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin. Appl. Environ. Microbiol. 63, 2147-2154.
9. Kirner, S., Hammer, P.E., Hill, D.S., Altmann, A., Fischer, I., Weislo, L.J., Lanahan, M., van Pée, K.-H. and Ligon, J.M. (1998) Functions encoded by pyrrolnitrin biosynthetic genes from Pseudomonas fluorescens. J. Bacteriol. 180, 1939-1943.
10. Hohaus, K., Altmann, A., Burd, W., Fischer, I., Hammer, P.E., Hill, D.S., Ligon, J.M. and van Pée, K.-H. (1997) NADH-dependent halogenases are more likely to be involved in halometabolite biosynthesis than haloperoxidases. Angew. Chem. Int. Ed. Engl. 36, 2012-2013.
11. Hill, D.S., Stein, J.I., Torkewitz, N.R., Morse, A.M., Howell, C.R., Pachlatko, J.P., Becker, J.O. and Ligon, J.M. (1994) Cloning of genes involved in the synthesis of pyrrolnitrin from Pseudomonas fluorescens and the role of pyrrolnitrin synthesis in biological control of plant disease. Appl. Environ. Microbiol. 60, 78-85.
12. Roitman, J.N., Mahoney, N.B. and Janisiewicz, W.J. (1990) Production and composition of phenylpyrrole metabolites produced by Pseudomonas cepacia. Appl. Microbiol. Biotechnol. 34, 381-386.
13. Keel, C., Voisard, C., Berling, C.H., Kahr, G. and Defago, G. (1989) Iron sufficiency, a prerequisite for the suppression of tobacco black root rot by Pseudomonas fluorescens strain CHAO under gnotobiotic conditions. Phytopathology 79, 584-589.
14. Salcher, O. and Lingens, F. (1980) Isolation and characterization of a mutant of Pseudomonas aureofaciens ATCC 15926 with an increased capacity for synthesis of pyrrolnitrin. J. Gen. Microbiol. 118, 828-829.
15. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Press, Cold Spring Harbor, NY.
16. Church, G.M. and Gilbert, W. (1984) Genomic sequencing. Proc. Natl. Acad. Sci. USA 81, 1991-1995.