Minor long-term changes in weight have beneficial effects on insulin sensitivity and β-cell function in obese subjects

Diabetes, Obesity and Metabolism

Volumn 4, Issue 1, 2002, Pages 19-28

  Rosenfalck, A M ^a   Hendel, H ^a   Rasmussen, M H ^a   Almdal, T ^a   Andersen, T ^a,b   Hilsted, J ^a   Madsbad, S ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b ROSKILDE HOSPITAL   (Denmark)

Author keywords

Body composition; DXA scanning; Frequently sampled intravenous glucose tolerance test (FSIGT); Insulin sensitivity; Obesity; Oral glucose tolerance test (OGTT)

Indexed keywords

ANTIOBESITY AGENT; C PEPTIDE; DIURETIC AGENT; ENZYME INHIBITOR; FAT; GLUCOSE; HORMONE; INSULIN; PLACEBO; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE;

ADULT; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CALORIC RESTRICTION; CELL FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INSULIN RESPONSE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LOW FAT DIET; MALE; MULTIPLE REGRESSION; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; WEIGHT GAIN; WEIGHT REDUCTION; WHOLE BODY SCINTISCANNING;

EID: 0036222047     PISSN: 14628902     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1463-1326.2002.00161.x     Document Type: Article

References (51)

1. Relationships of generalized and regional adiposity to insulin sensitivity in men
2. Effects of age and body fat on insulin resistance in healthy men
3. Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM
4. Relation of body fat distribution to metabolic complications of obesity
5. Obesity fat distribution, and weight gain as risk factors for clinical diabetes in men
6. Weight as a risk factor for clinical diabetes in women
7. Weight gain as a risk factor for clinical diabetes mellitus in women
8. Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men
9. Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study
10. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13-year follow-up of participants in the study of men born in 1913
11. A prospective study of obesity and risk of coronary heart disease in woman
12. Effects of body composition on insulin sensitivity
13. Following weight loss in massively obese patients correction of the insulin resistance of fat metabolism is delayed relative to the improvement in carbohydrate metabolism
14. Effects of weight loss in massive obesity on insulin and C-peptide dynamics: Sequential changes in insulin production, clearance and sensitivity
15. Insulin secretion, clearance and action before and after gastroplasty in severely obese subjects
16. Postgastroplasty recovery of ideal body weight normalizes glucose and insulin metabolism in obese women
17. Effects of weight reduction after gastroplasty on glucose and lipid metabolism
18. Beta-cell function and insulin action after weight reduction in obesity and non- insulin-dependent diabetes mellitus
19. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: The 6-year Malmo feasibility study
20. The beneficial effects of modest weight loss on cardiovascular risk factors
21. Prediction of glucose response to weight loss in patients with non-insulin-dependent diabetes mellitus
22. Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients
23. Lifestyle intervention in overweight individuals with a family history of diabetes
24. Treatment of obesity in patient groups
25. Mode of action of orlistat
26. Weight loss during 12 weeks ad libitum carbohydrate-rich diet in overweight and normal-weight subjects at a Danish work site
27. Dietary guidelines on obesity at Danish pharmacies: Results of a 12-week course with a 1-year follow-up
28. Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers
29. Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: A 1-year study
30. A 1-year trial to assess the value of orlistat in the management of obesity
31. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients
32. Body composition analysis by DEXA by using dynamically changing samarian filtration
33. MINMOD: A computer program to calculate insulin sensitivity and pancreatic responsitivity from the frequently sampled intraveneous glucose tolerance test
34. The insulin sensitivity index in nondiabetic man: Correlation between clamp-derived and IVGTT-derived values
35. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
36. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: Evidence for a hyperbol function
37. Body composition in normal subjects: Relation to lipid and glucose variables
38. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM
39. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
40. Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men
41. Effect of weight loss on glucose disposal in obese and obese diabetic patients
42. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity
43. Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome
44. The effects of weight loss in obese subjects on the thermogenic, metabolic and haemodynamic responses to the glucose clamp
45. Long-term changes in insulin action and insulin secretion associated with gain, loss regain and maintenance of body weight
46. Beneficial health effects of modest weight loss
47. Relationship between degree of obesity and in vivo insulin action in man
48. Dual energy X-ray absorptiometry assessment of fat mass distribution and its association with the insulin resistance syndrome
49. Effects of free fatty acids and glucose on splanchnic insulin dynamics
50. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
51. Impaired glucose tolerance: Fact or fiction