Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: A 1-y study

American Journal of Clinical Nutrition

Volumn 69, Issue 6, 1999, Pages 1108-1116

  Hill, James O ^a   Hauptman, Jonathan ^a   Anderson, James W ^a   Fujioka, Ken ^a   O'Neil, Patrick M ^a   Smith, Diane K ^a   Zavoral, James H ^a   Aronne, Louis J ^a  

^a NONE

Author keywords

Cardiovascular disease risk factors; Humans; Lipase inhibition; Lipids; Obesity; Orlistat; Weight loss; Weight maintenance

Indexed keywords

CENTRUM; FECES LIPID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MULTIVITAMIN; PLACEBO; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; BEHAVIOR MODIFICATION; CALORIC INTAKE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; LIPID ABSORPTION; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; WEIGHT GAIN; WEIGHT REDUCTION;

EID: 0033020351     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/69.6.1108     Document Type: Article

References (21)

1. Flegal K, Carroll M, Kuczmarski R, Johnson C. Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord 1998;22:38-47.
2. Eckel R, Krauss R. American Heart Association call to action: obesity as a major risk factor for coronary heart disease. Circulation 1998;97:2099-100.
3. Goldstein DJ. Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord 1992;16:397-415.
4. Pi-Sunyer F. Short-term medical benefits and adverse effects of weight loss. Ann Intern Med 1993;119:722-6.
5. NHLBI Obesity Education Initiative Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. Bethesda, MD: National Heart, Lung, and Blood Institute, National Institutes of Health, 1998.
6. NIH Technology Assessment Conference Panel. Methods for voluntary weight loss and control. Ann Intern Med 1993;119:764-70.
7. Wadden TA. Treatment of obesity by moderate and severe caloric restriction: results of clinical research trials. Ann Intern Med 1993;119:688-93.
8. Safer DJ. Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective. South Med J 1991;84:1470-4.
9. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995;332:621-8.
10. Zhi J, Melia AT, Guerciolini R, et al. Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers. Clin Pharmacol Ther 1994;56:82-5.
11. Drent ML, van der Veen EA. Lipase inhibition: a novel concept in the treatment of obesity. Int J Obes Relat Metab Disord 1993;17:241-4.
12. Drent ML, Larsson L, William-Olsson T, et al. Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study. Int J Obes Relat Metab Disord 1995;19:221-6.
13. Sjöström L, Rissanen A, Andersen T, et al. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Lancet 1998;352:167-73.
14. World Health Organization. Energy and protein requirement. Report of a joint FAO/WHO/UNU Expert Consultation. World Health Organ Tech Rep Ser 1985;724.
15. Winer BJ. Statistical principles in experimental design. 2nd ed. New York: McGraw-Hill, 1971.
16. Grundy SM. Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 1998;67(suppl):563S-72S.
17. Willett WC. Is dietary fat a major determinant of body fat? Am J Clin Nutr 1998;67(suppl):555S-62S.
18. Blundell JE, Macdiarmid JI. Passive overconsumption. Fat intake and short-term energy balance. Ann N Y Acad Sci 1997;827:392-407.
19. Horton TJ, Drougas H, Brachey A, Reed GW, Peters JC, Hill JO. Fat and carbohydrate overfeeding in humans: different effects on energy storage. Am J Clin Nutr 1995;62:19-29.
20. Astrup A, Buemann B, Christensen NJ, Toubro S. Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women. Am J Physiol 1994;266:E592-9.
21. Guy-Grand B, Crepaldi G, Lefebvre P, et al. International trial of long-term dexfenfluramine in obesity. Lancet 1989;2:1142-4.