Human natural killer cell line modified with a chimeric immunoglobulin T-cell receptor gene leads to tumor growth inhibition in vivo

Cancer Gene Therapy

Volumn 9, Issue 4, 2002, Pages 390-398

  Schirrmann, Thomas ^a   Pecher, Gabriele ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Carcinoembryonic antigen; Chimeric receptor; NK cells; Tumor targeting

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CD3 ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CHIMERA; COLON CARCINOMA; CONTROLLED STUDY; CYTOLYSIS; DNA MODIFICATION; EFFECTOR CELL; GAMMA IRRADIATION; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NATURAL KILLER CELL; PRIORITY JOURNAL; SCID MOUSE;

ANIMALS; ANTIGENS, CD3; ANTIGENS, NEOPLASM; CARCINOEMBRYONIC ANTIGEN; CYTOTOXICITY TESTS, IMMUNOLOGIC; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; FLOW CYTOMETRY; GAMMA RAYS; GENES, T-CELL RECEPTOR; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; KILLER CELLS, NATURAL; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASMS; POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR ESCAPE;

EID: 0036221688     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700453     Document Type: Article

References (43)

1. Recombinant T- cell receptors: An immunologic link to cancer therapy
2. Tumor-specific T-bodies: Towards clinical application
3. Single-chain antigen-binding proteins
4. An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability
5. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
6. Kat: A high-efficiency retroviral transduction system for primary human T lymphocytes
7. Aretroviral vector system "STITCH" in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes
8. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
9. Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain
10. Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor
11. A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA
12. Specific targeting of EGP-2+ tumor cells by primary lymphocytes modified with chimeric T cell receptors
13. Dynamics of tumor cell killing by human T lymphocytes armed with an anti-carcinoembryonic antigen chimeric immunoglobulin T-cell receptor
14. NK cell activation: Distinct stimulatory pathways counterbalancing inhibitory signals
15. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
16. Immunotherapy of liver metastases of human gastric carcinoma with interleukin 2-activated natural killer cells
17. Human tumor antigen-specific T lymphocytes and interleukin-2-activated natural killer cells: Comparisons of antitumor effects in vitro and in vivo
18. Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors
19. Chimeric zeta-receptors direct human natural killer (NK) effector function to permit killing of NK-resistant tumor cells and HIV-infected T lymphocytes
20. Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo
21. Characterization of genetically altered, interleukin 2-independent natural killer cell lines suitable for adoptive cellular immunotherapy
22. Restoration of lytic function in a human natural killer cell line by gene transfection
23. TCGF (IL 2)-receptor inducing factor(s): I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells)
24. The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues
25. Humanization of monoclonal antibodies
26. Characterisation of a humanised bispecific monoclonal antibody for cancer therapy
27. Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas
28. 99Tcm-labelled anti-CEA monoclonal antibody for tumour immunoscintigraphy: First clinical results
29. 111indium-labelled monoclonal anti-CEA antibody BW 431/26
30. A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity
31. In vitro and in vivo antitumor properties of a T-cell clone generated from murine tumor-infiltrating lymphocytes
32. Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line
33. Characterization of the epitope recognized by a monoclonal antibody directed against the largest subunit of Drosophila RNA polymerase II
34. By-passing immunization: Building high affinity human antibodies by chain shuffling
35. The nucleotide sequence of a human immunoglobulin C gammal gene
36. Heparin can activate a receptor tyrosine kinase
37. Targeting vectors for intracellular immunisation
38. Growth of tumor-infiltrating lymphocytes from human solid cancers: Summary of a 5-year experience
39. Cell therapy: Achievements and perspectives
40. T cell activation by recombinant Fc epsilon RI gamma-chain immune receptors: An extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition
41. Binding reactivity of monoclonal anti-carcinoembryonic antigen (CEA) antibodies with cell membrane-bound CEA and with free CEA in solution
42. Phase I trial of TALL-104 cells in patients with refractory metastatic breast cancer
43. Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo