Role of ether-linked lysophosphatidic acids in ovarian cancer cells

Journal of Lipid Research

Volumn 43, Issue 3, 2002, Pages 463-476

  Lu, Jun ^a   Xiao, Yi Jin ^a   Baudhuin, Linnea M ^a,b   Hong, Guiying ^a   Xu, Yan ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

Author keywords

Alkenyl LPA; Alkyl lysophosphatidic acid; Mitogen activated protein kinase; Ovarian cancer; Protein kinase B

Indexed keywords

ALKENYL GROUP; ALKYL GROUP; CELL DNA; ETHER; INTERLEUKIN 8; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RHO FACTOR; SYNAPTOPHYSIN;

ANGIOGENESIS; ARTICLE; ASCITES; CANCER CELL; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIPID ANALYSIS; METASTASIS; MITOGENESIS; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ASCITES; CELL MOVEMENT; COLLAGEN TYPE I; DNA; ENZYME ACTIVATION; FEMALE; HUMANS; INTERLEUKIN-8; LYSOPHOSPHOLIPIDS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; OVARIAN NEOPLASMS; PHOSPHOLIPID ETHERS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR CELLS, CULTURED;

EID: 0036208331     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Bioactive lysophospholipids and their G protein-coupled receptors
2. Lysophosphatidic acid: G-protein signalling and cellular responses
3. Lipid second messengers
4. The role and clinical applications of bioactive lysolipids in ovarian cancer
5. The synergistic interactions of oleoyl-lysophosphatidic acid in platelet aggregation
6. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate
7. Lysophosphatidic acid receptors
8. The bioactive phospholipid lysophosphatidic acid is released front activated platelets
9. Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells
10. Injury-related factors and conditions clown-regulate the thrombin receptor (PAR-1) in a human neuronal cell line
11. Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing
12. Growth factor-like phospholipids generated after corneal injury
13. Synergistic inhibition of lysophosphatidic acid signaling by charged and uncharged local anesthetics
14. Phospholipid growth factors and corneal wound healing
15. Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells
16. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
17. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
18. Life on the edg
19. Bioactive lysophospholipids and their G protein-coupled receptors
20. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients
21. Lysophospholipids activate ovarian and breast cancer cells
22. Effect of lysophospholipids on signaling in the human Jurkat T cell line
23. Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells
24. Lysophospholipids increase interleukin-8 expression in ovarian cancer cells
25. Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells
26. Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase
27. Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells
28. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers
29. Lysophosphatidic acid signalling
30. Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: A new group of phospholipid mediators?
31. Signaling responses to alkyllysophosphatidic acid: The activation of phospholipases A2 and C and protein tyrosine phosphorylation in human platelets
32. Identification of a novel growth factor-like lipid, 1-O-cis-alk-1′-enyl-2-lyso-sn-glycero-3-phosphate (alkenyl-GP) that is present in commercial sphingolipid preparations
33. Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes
34. Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells
35. Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: Comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids
36. Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) analyses
37. Sphingosine 1-phosphate stimulates G(i)- and rhomediated vascular endothelial cell spreading and migration
38. Mitogen- and stress-activated protein kinase-1 mediates activation of Akt by ultraviolet B irradiation
39. Activation of akt1 by human 5-hydroxytryptamine (serotonin) (1b) receptors is sensitive to inhibitors of mek
40. Signalling properties of lysophosphatidic acid in primary human skin fibroblasts: Role of pertussis toxin-sensitive GTP-binding proteins
41. Synergism among lysophosphatidic acid, betalA integrins, and epidermal growth factor or platelet-derived growth factor in mediation of cell migration
42. Sphingosine-l-phosphate and lysophosphatidic acid stimulate endothelial cell migration
43. Rho GTPases control polarity, protrusion, and adhesion during cell movement
44. Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells
45. Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes
46. Invasion of T-lymphoma cells: Cooperation between Rho family GTPases and lysophospholipid receptor signaling
47. Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways
48. The chemotactic response to PDGF-BB: Evidence of a role for Ras
49. Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type 1 collagen mediated by the alpha2betal integrin
50. Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases
51. Interleukin-8 as a macrophage-derived mediator of angiogenesis
52. Diagnostic and therapeutic applications of angiogenesis research
53. Tumor-host interaction: Analysis of cytokines, growth factors, and tumor-infiltrating lymphocytes in ovarian carcinomas
54. Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice
55. Angiogenic activity and interleukin-8 content of human ovarian cancer ascites
56. The chemotactic cytokine interleukin-8 - A cyst fluid marker for malignant epithelial ovarian cancer?
57. Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line
58. Synthesis of ether-linked analogues of lysophosphatidate and their effect on the proliferation of human epithelial cancer cells in vitro
59. Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity
60. Lipid phosphate phosphatase-1 dephosphorylates exogenous lysophosphatidate and thereby attenuates its effects on cell signalling
61. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for akt in human neutrophils
62. A novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid with unsaturated fatty-acid moiety
63. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid
64. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization