Dysregulation of the right brain: A fundamental mechanism of traumatic attachment and the psychopathogenesis of posttraumatic stress disorder

Australian and New Zealand Journal of Psychiatry

Volumn 36, Issue 1, 2002, Pages 9-30

  Schore, Allan N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Attachment; Child abuse; Dissociation; Right brain; Trauma

Indexed keywords

ADULT; AFFECT; AFFECTIVE NEUROSIS; AROUSAL; AUTONOMIC NERVOUS SYSTEM; BRAIN DYSFUNCTION; CENTRAL NERVOUS SYSTEM; CHILD; CHILD ABUSE; CHILD PSYCHIATRY; CLINICAL RESEARCH; CONTROLLED STUDY; COPING BEHAVIOR; DISEASE PREDISPOSITION; DISSOCIATION; EMOTIONAL ATTACHMENT; FEMALE; HUMAN; INFANT; LEARNING; LIMBIC SYSTEM; MALE; NERVOUS SYSTEM DEVELOPMENT; NEUROPSYCHIATRY; PATHOGENESIS; POSTTRAUMATIC STRESS DISORDER; REVIEW; RIGHT HEMISPHERE; STRESS; SYMPTOMATOLOGY;

ADOLESCENT; ADULT; AROUSAL; AUTONOMIC NERVOUS SYSTEM; BRAIN; CHILD; CHILD ABUSE; CHILD, PRESCHOOL; DOMINANCE, CEREBRAL; FEMALE; HUMANS; INFANT; MALE; REACTIVE ATTACHMENT DISORDER; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 0036205385     PISSN: 00048674     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1614.2002.00996.x     Document Type: Review

References (246)

1. Posttraumatic stress disorder in the National Comorbidity Survey
2. Chronicity in posttraumatic stress disorder (PTSD) and predictors of course of comorbid PTSD in patients with anxiety disorders
3. An overview of research findings on the nature of posttraumatic stress disorder
4. Relationship among plasma cortisol, catecholamines, neuropeptide Y, and human performance during exposure to uncontrollable stress
5. Traumatic stress and developmental psychopathology in children and adolescents
6. Post traumatic stress disorder: DSM-IV and beyond
7. Clinical treatment of posttraumatic stress disorder: Conceptual challenges raised by recent research
8. The legacy of early attachments
9. Maternal care and the development of stress responses
10. The ontogeny of the hypothalamic-pituitary-adrenal axis: The influence of maternal factors
11. Repeated isolation in the neonatal rat produces alterations in behavior and ventral striatal dopamine release in the juvenile after amphetamine challenge
12. Behavioral inhibition and stress reactivity: Moderating role of attachment security
13. Affect regulation and the origin of the self: The neurobiology of emotional development
14. Early shame experiences and the development of the infant brain
15. Plenary address: Parent-infant communications and the neurobiology of emotional development
16. The effects of a secure attachment relationship on right brain development, affect regulation, and infant mental health
17. Effects of early stress on adult affiliative behavior
18. From survival to fulfillment. A framework for the life-trauma dialectic
19. The developing mind: Toward a neurobiology of interpersonal experience
20. Down will come baby, cradle and all: Diagnostic and therapeutic implications of chronic trauma on child development
21. Corticosteroids in relation to fear, anxiety and psychopathology
22. Attachment theory and its therapeutic implications
23. The right hemisphere and the human stress response
24. The right brain hemisphere is dominant in human infants
25. Age-related changes of brain gray and white matter in healthy infants and children
26. Psychological and physiological responses to stress: The right hemisphere and the hypothalamo-pituitary-adrenal axis, an inquiry into problems of human bonding
27. The experience-dependent maturation of a regulatory system in the orbital prefrontal cortex and the origin of developmental psychopathology
28. Interdisciplinary developmental research as a source of clinical models
29. Attachment and the regulation of the right brain
30. Traumatic stress and attachment
31. Child maltreatment and attachment theory
32. The effects of maltreatment on the development of young children
33. Developmental traumatology. Part I, Biological stress systems
34. Social stress, autonomic neural activation, and cardiac activity in rats
35. Developmental traumatology: The psychobiological development of maltreated children and its implications for research, treatment, and policy
36. The neurobiology of stress: From serendipity to clinical relevance
37. Early organization of the nonlinear right brain and development of a predisposition to psychiatric disorders
38. Early trauma and the development of the right brain
39. Early trauma and the development of the right brain
40. Early trauma and the development of the right brain
41. The enduring effects of early trauma on the right brain
42. The effects of relational trauma on right brain development, affect regulation, and infant mental health
43. The self-organization of the right brain and the neurobiology of emotional development
44. The right brain as the neurobiological substratum of Freud's dynamic unconscious
45. Right cerebral hemisphere dominance for a sense of corporeal and emotional self
46. Cortical systems for the recognition of emotion in facial expressions
47. Understanding emotional prosody activates right hemispheric regions
48. Right hemisphere emotional perception: Evidence across multiple channels
49. Activation of the right inferior frontal cortex during assessment of facial emotion
50. Neuropsychological aspects of facial asymmetry during emotional expression: A review of the adult literature
51. The role of the right hemisphere in emotional communication
52. Facial reactions to happy and angry facial expressions: Evidence for right hemisphere dominance
53. Differential hemispheric lateralization of primary and social emotions. Implications for developing a comprehensive neurology for emotions, repression, and the subconscious
54. The experience-dependent maturation of an evaluative system in the cortex
55. Remembering, forgetting, and the effects of trauma on memory: A developmental psychopathologic perspective
56. Childhood abuse and neglect and loss of self-regulation
57. Perinatal distress leads to lateralized medial prefrontal cortical dopamine hypofunction in adult rats
58. The effects of neonatal stress on brain development: Implications for psychopathology
59. Disorders of affect regulation: Alexithymia in medical and psychiatric illness
60. Self-regulation and cortical development: Implications for functional studies of the brain
61. Cerebral representation of one's own past: Neural networks involved in autobiographical memory
62. Functional delineation of the human occipito-temporal areas related to face and scene processing: A PET study
63. What happens to early memories of trauma?
64. The body keeps the score: Approaches to the psychobiology of posttraumatic stress disorder
65. Right hemisphere dominance of inhibitory control: An event-related functional MRI study
66. A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery
67. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation
68. Reduced hippocampal volume and n-acetyl aspartate in posttraumatic stress disorder
69. Cortical asymmetries in frontal lobes of Rhesus monkeys (Macaca mulatta)
70. Increased orbital frontal cortex blood flow and hippocampal abnormality in PTSD: A pilot PET study
71. Neural circuits and mechanisms of post-traumatic stress disorder
72. A model of the stress-induced activation of prefrontal cortical dopamine systems: Coping and the development of post-traumatic stress disorder
73. Positron emission tomography measurement of cerebral metabolic correlates of yohimbe administration in combat-related posttraumatic stress disorder
74. Olfactory identification in combat-related posttraumatic stress disorder
75. Working memory in posttraumatic stress disorder - An event-related potential study
76. Dissociative flashbacks after right frontal injury in a Vietnam veteran with combat-related posttraumatic stress disorder
77. Measures of prefrontal system dysfunction in posttraumatic stress disorder
78. Modulating emotional responses: Effects of a neocortical network on the limbic system
79. The right brain, the right mind, and psychoanalysis
80. Transmitter systems involved in neural plasticity underlying increased anxiety and defense-implications for understanding anxiety following traumatic stress
81. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge
82. Emotion recognition from faces and prosody following temporal lobectomy
83. A subcortical pathway to the right amygdala mediating 'unseen' fear
84. Differential acquisition of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats
85. Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial MRI study
86. Extinction of emotional learning: Contribution of medial prefrontal cortex
87. Development of dissociative disorders
88. Introduction to the special section on attachment and psychopathology: Overview of the field of attachment
89. Disorganized/disoriented attachment in the etiology of the dissociative disorders
90. Early relational trauma and the development of the right brain
91. Glutamate and post-traumatic stress disorder: Toward a psychobiology of dissociation
92. The prisoners of despair: Right hemisphere deficiency and suicide
93. Brain asymmetry
94. The role of right hemisphere dysfunction in psychiatric disorders
95. Self-recognition and the right hemisphere
96. Traumatic stress in the 21st century
97. The development of neurodevelopmental psychiatry
98. The concept of affect: A re-examination
99. Emotional development: The organization of emotional life in the early years
100. The interpersonal world of the infant
101. Maternal sensitivity as an organizer for biobehavioral regulation in infancy
102. Evolutionary psychiatry and the triune brain
103. From sensation to cognition
104. Developing emotions and cortical networks
105. The role of the right hemisphere in the physiological and cognitive components of emotional processing
106. Progressive postnatal assembly of limbic-autonomic circuits revealed by central transneuronal transport of pseudorabies virus
107. The seventh annual John Bowlby memorial lecture, Minds in the making: Attachment, the self-organizing brain, and developmentally-oriented psychoanalytic psychotherapy
108. Networks related to the orbital and medial prefrontal cortex; a substrate for emotional behavior?
109. Contributions of anterior cingulate cortex to behaviour
110. Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys
111. Emotions
112. The anatomical connections of the macaque monkey orbitofrontal cortex. A review
113. Nature and autonomy: An organizational view of social and neurobiological aspects of self-regulation in behavior and development
114. Autonomic determinism. The modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint
115. Glucose polymerisation and cortisol
116. Regulation of glycogen metabolism in liver by the autonomic nervous system. IV. Activation of glycogen synthetase by vagal stimulation
117. Regulation of glycogen metabolism in liver by the autonomic nervous system. II. Neural control of glycogenolytic enzymes
118. Descartes' error
119. Hemispheric lateralization of somatosensory processing
120. Cerebral hemispheric lateralization in cardiac autonomic control
121. Suppression of cardiac parasympathetic functions in patients with right hemispheric stroke
122. The polyvagal theory phylogenetic substrates of a social nervous system
123. Prefrontal cortical of the autonomic nervous system: Anatomical and physiological observations
124. Anatomy and function of the orbital frontal cortex. Function and relevance to obsessive-compulsive disorder
125. A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mapping
126. The unbearable automaticity of being
127. Classical conditioning and implicit learning: The right hemisphere hypothesis
128. Emotion and self-regulation
129. Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: Evidence from PET
130. Dissociable functions in the medial and lateral orbitofrontal cortex: Evidence from human neuroimaging studies
131. Crossmodal associative memory representations in rodent orbitofrontal cortex
132. Treating the adult survivor of childhood sexual abuse. A psychoanalytic perspective
133. Betrayal trauma theory: The logic of forgetting childhood abuse
134. Depressed mothers and infants: Failure to form dyadic states of consciousness
135. Childhood trauma, the neurobiology of adaptation, and 'use-dependent' development of the brain: How 'states' become 'traits'
136. Coconstructing mother-infant distress the microsychrony of maternal impingement and infant avoidance in the face-to-face encounter
137. Corticotropin-releasing factor: Actions on the sympathetic nervous system and metabolism
138. Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus
139. A.T. Locus coeruleus, stress, and PTSD: Neurobiological and clinical parallels
140. Stress-triggered activation of gene expresion in catecholaminergic systems: Dynamics of transcriptional events
141. Thyroid hormone-catecholamine relationships
142. Effects of thyroid hormones during brain differentiation
143. Do neurotransmitters, neurohumors, and hormones specify critical periods?
144. Hypothalamic regulation of plasma catecholamine levels during stress: Effect of vasopressin and CRF
145. Regulation of the sympathetic nervous system by circulating vasopressin
146. Vasopressin and oxytocin responses to illusory self-motion and nausea in man
147. Human development and homeostasis
148. Multiple personality disorder as an attachment disorder
149. Learning from experience
150. Multiple selves, multiple voices: Working with trauma, violation and dissociation
151. Dissociation in children and adolescents: A developmental perspective
152. Ethological strategies for defense in animals and humans: Their role in some psychiatric disorders
153. Condtioned fear-induced opiate analgesia. A compelling motivational state theory of stress analgesia
154. Emotion: An evolutionary by-product of the neural regulation of the autonomic nervous system
155. The contribution of Hughlings Jackson to an understanding of dissociation
156. Discovery of an insecure-disorganized/disoriented attachment pattern: Procedures, findings and implications for the classification of behavior
157. Disorganized/disoriented attachment relationships in maltreated infants
158. Adrenocortical responses to the strange situation in infants with disorganized/disoriented attachment relationships
159. Individual and physiological correlates of attachment disorganization in infancy
160. Orbitofrontal cortex: A key prefrontal region for encoding information
161. Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex
162. Second-generation effects of unresolved trauma in nonmaltreating parents: Dissociated, frightened, and threatening parental behavior
163. Frightening maternal behavior linking unresolved loss and disorganized infant attachment
164. Association of maladaptive parental behavior with psychiatric disorder among parents and their offspring
165. Childhood trauma and risk for PTSD: Relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion
166. Quantitative growth and development of human brain
167. Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system
168. Neuroendocrine hemisphere asymmetries: Salivary cortisol secretion during lateralized viewing of emotion-related and neutral films
169. Inferior petrosal sinus sampling in healthy human subjects reveals a unilateral corticotropin-releasing hormone-induced arginine vasopressin release associated with ipsilateral adrenocorticotropin secretion
170. Linking the neuroendocrinology of post-traumatic stress disorder with recent neuroanatomic findings
171. Programmed cell death: Implications for neuropsychiatric disorders
172. Adrenal steroids regulate postnatal development of the rat dentate gyrus: Effects of glucocorticoids on cell death
173. Low cortisol and a flattening of expected daytime rhythm: Potential indices of risk in human development
174. Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event
175. Motivation of neural plasticity: Neural mechanisms in the self-organization of depression
176. Recurrent affective disorder. Roots in developmental neurobiology and illness progression based on changes in gene expression
177. Psychophysiological evidence for autonomic arousal and startle in traumatized adult populations
178. Abnormal noradrenergic function in posttraumatic stress disorder
179. CSF norepinephrine concentrations in posttraumatic stress disorder
180. Neurologic soft signs in chronic posttraumatic stress disorder
181. Stressor-induced oscillation: A possible model of the bidirectional symptoms in PTSD
182. Kindling versus quenching: Implications for the evolution and treatment of posttraumatic stress disorder
183. Memory, attention, and executive deficits in POW survivors: Contributing biological and psychological factors
184. Memory and attention in combat-related post-traumatic stress disorder (PTSD)
185. Neural correlates of exposure to traumatic pictures and sound in combat veterans with and without posttraumatic stress disorder: A positron emission tomography study
186. Potential role of the anterior cingulate cortex in PTSD: Review and hypothesis
187. Dissociation of sympathetic nervous system and adrenal medullary responses
188. The orbitofrontal cortex
189. Lateralization of emotion: A model and the evidence
190. Evidence that limbic neural plasticity in the right hemisphere mediates partial kindling induced lasting increases in anxiety-like behavior: Effects of low frequency stimulation (Quenching?) on long-term efferents and behavior following kindling
191. Emotional neurophysiology of the amygdala within the context of human cognition
192. The role of the amygdala and its efferent projections in fear and anxiety
193. Corticosterone potentiation of learned fear
194. Hemispheric asymmetry in conditioning to facial emotional expressions
195. Conscious and unconscious emotional learning in the human amygdala
196. Differential involvement of the right and left amygdalae in expression of memory for aversively motivated training
197. Subliminal processing of emotional information in anxiety and depression
198. Lateralized startle probes in the study of emotion
199. Task-dependent early latency (30-60ms) visual processing of human faces and other objects
200. Hemispheric processing asymmetries: Implications for memory
201. Perceptual and semantic components of memory for objects and faces: A PET study
202. Clinical implications of a psychoneurobiological model of projective identification
203. Activation of the left amygdala to a cognitive representation of fear
204. Brain activity during biofeedback relaxation. A functional neuroimaging investigation
205. Selection of currently relevant memories by the human posterior medial orbitofrontal cortex
206. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study
207. N-acetylaspartate concentration in anterior cingulate with PTSD
208. A pilot study of amygdala volume in pediatric generalized anxiety disorder
209. Reduced right hemisphere activation in severely abused violent offenders during a working memory task: An fMRI study
210. A 'cure' for chronic combat-related posttraumatic stress disorder secondary to a right frontal lobe infarct: A case report
211. Evoked potential evidence for right brain activity during the recall of traumatic memories
212. While a phobic waits: Regional brain electrical and autonomic activity in social phobics during anticipation of public speaking
213. Brain electrical microstates in subjects with panic disorder
214. Animal defensive reactions as a model for trauma-induced dissociative reactions
215. Disorganized attachment in early childhood. Meta-analysis of precursors, concomitants, and sequelae
216. Dissociation and vulnerability to psychotic experience. The Dissociative Experiences Scale and the MMPI-2
217. Development and the fragmented self: Longitudinal study of dissociative symptomatology in a nonclinical sample
218. Predictors of posttraumatic stress symptoms among survivors of the Oakland/Berkeley, California, firestorm
219. Predictors of PTSD in injured trauma survivors: A prospective study
220. The body bears the burden: Trauma, dissociation, and disease
221. Somatoform dissociation: Major symptoms of dissociative disorders
222. Emotional and physiological responses to false feedback
223. Cyclical cortical reorganization: Origins of human cognitive development
224. Preliminary evidence for abnormal cortical development in physically and sexually abused children using EEG coherence and MRI
225. An outline of the role of brain in human cognitive development
226. Effect of subjective perspective taking during simulation of action: A PET investigation of agency
227. The black hole of trauma
228. The mysterious orbitofrontal cortex. Foreword
229. Integration and self-healing: Affect-trauma-alexithymia
230. The laws of emotion
231. Progress on a cognitive-motivational-relational theory of emotion
232. Stages of decompensation in combat-related posttraumatic stress disorder: A new conceptual model
233. Dysfunction in the neural circuity of emotion regulation - A possible prelude to violence
234. Vagal rebound and recovery from psychological stress
235. Vagal modulation of responses to mental challenge in posttraumatic stress disorder
236. The use of psychoendocrine strategies in posttraumatic stress disorder
237. Psychogenic lowering of urinary cortisol levels linked to increased emotional numbing and a shame-depressive syndrome in combat-related posttraumatic stress disorder
238. Posttraumatic nightmares: Psychodynamic explorations
239. Personal relevance and the human right hemisphere
240. Attachment and psychosomatic medicine: Developmental contributions to stress and disease
241. Childhood attachment and loss experiences affect adult cardiovascular and cortisol function
242. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The adverse childhood experiences (ACE) study