Kindling versus quenching. Implications for the evolution and treatment of posttraumatic stress disorder

Annals of the New York Academy of Sciences

Volumn 821, Issue , 1997, Pages 285-295

  Post, Robert M ^a,b   Weiss, Susan R B ^a   Smith, Mark ^a   Li, He ^a   McCann, Una ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NTMH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; GENE EXPRESSION; HUMAN; KINDLING; NEUROBIOLOGY; PATHOLOGY; POSTTRAUMATIC STRESS DISORDER;

EID: 0030759713     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48287.x     Document Type: Conference Paper

References (50)

1. POST, R. M. 1992. Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. Am. J. Psychiatry 149: 999-1010.
2. BREMNER, J. D., S. M. SOUTHWICK, D. R. JOHNSON, R. YEHUDA & D. S. CHARNEY. 1993. Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. Am. J. Psychiatry 150: 235-239.
3. YEHUDA, R., B. KAHANA, J. SCHMEIDLER, S. M. SOUTHWICK, S. WILSON & E. L. GILLER. 1995. The impact of cumulative lifetime trauma and recent stress on current posttraumatic stress disorder symptoms in Holocaust survivors. Am. J. Psychiatry 152: 1815-1818.
4. YEHUDA, R. & S. M. ANTELMAN. 1993. Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol. Psychiatry 33: 479-486.
5. WEISS, S. R. B., R. M. POST, A. PERT, R. WOODWARD & D. MURMAN. 1989. Context-dependent cocaine sensitization: Differential effect of haloperidol on development versus expression. Pharmacol. Biochem. Behav. 34: 655-661.
6. POST, R. M., S. R. B. WEISS, D. FONTANA & A. PERT. 1992. Conditioned sensitization to the psychomotor stimulant cocaine. Ann. N.Y. Acad. Sci. 654: 386-399.
7. PERT, A., R. M. POST & S. R. B. WEISS. 1990. Conditioning as a critical determinant of sensitization induced by psychomotor stimulants. In Neurobiology of Drug Abuse: Learning and Memory, NIDA Research Monograph 97. L. Erinoff, Ed.: 208-241. U.S. Government Printing Office. Washington, DC.
8. POST, R. M., S. R. B. WEISS & M. SMITH. 1995. Sensitization and kindling: Implications for the evolving neural substrate of PTSD. In Neurobiology and Clinical Consequences of Stress: From Normal Adaptation to PTSD. M. J. Friedman, D. S. Charney & A. Y. Deutch, Eds. Chap. 12: 203-224. Lippincott-Raven. Philadelphia, PA.
9. WEISS, S. R. B. & R. M. POST. 1995. Caveats in the use of the kindling model of affective disorders. J. Toxicol. Indust. Health 10: 421-447.
10. POST, R. M., S. R. B. WEISS & G. S. LEVERICH. 1994. Recurrent affective disorder: Roots in developmental neurobiology and illness progression based on changes in gene expression. In Development and Psychopathology. D. Cicchetti & D. Tucker, Eds. Vol. 6: 781-813. Cambridge University Press. New York, NY.
11. POST, R. M., S. R. B. WEISS, G. S. LEVERICH, M. S. GEORGE, M. FRYE & T. A. KETTER. 1996. Developmental psychobiology of cyclic affective illness: Implications for early therapeutic intervention. In Development and Psychopathology. D. Cicchetti & D. Tucker, Eds. Vol. 8: 273-305. Cambridge University Press. New York, NY.
12. POST, R. M. & S. R. B. WEISS. 1996. A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures. Mol. Neurobiol. 12: 39-66.
13. POST, R. M. & S. R. B. WEISS. 1992. Endogenous biochemical abnormalities in affective illness: Therapeutic vs. pathogenic. Biol. Psychiatry 32: 469-484.
14. WEISS, S. R. B., M. CLARK, J. B. ROSEN, M. A. SMITH & R. M. POST. 1995. Contingent tolerance to the anticonvulsant effects of carbamazepine: Relationship to loss of endogenous adaptive mechanisms. Brain Res. Rev. 20: 305-325.
15. SMITH, M. A., S. MAKINO, R. KVETNANSKY & R. M. POST. 1995. Stress and glucocorticoids affect the expression of brain-derived neurotropic factor and neurotrophin-3 mRNAs in the hippocampus. J. Neurosci. 15: 1768-1777.
16. SMITH, M. A. 1996. Hippocampal vulnerability to stress and aging: Possible role of neurotrophic factors. Behav. Brain Res. 78: 25-36.
17. SMITH, M., S. R. B. WEISS, T. ABEDIN, R. M. POST & P. GOLD. 1991. Effects of amygdala-kindling and electroconvulsive seizures on the expression of corticotropin releasing hormone (CRH) mRNA in the rat brain. Mol. Cell. Neurosci. 2: 103-116.
18. ROSEN, J. B., C. J. CAIN, S. R. B. WEISS & R. M. POST. 1992. Alterations in mRNA of enkephalin, dynorphin and thyrotropin releasing hormone during amygdala kindling: An in situ hybridization study. Brain Res. Mol. Brain Res. 15: 247-255.
19. ZHANG, L. X., L. ZHANG, M. A. SMITH, J. C. REED, M. CLARK, A. N. FELDMAN, D. R. RUBINOW & R. M. POST. 1995. Ratio of BCL-2 and bax during development and apoptosis of neurons in the CNS (abstr). Abstr. Soc. Neurosci. Mtng. 21 (part 1): 559.
20. CAVAZOS, J. E. & T. P. SUTULA. 1990. Progressive neuronal loss induced by kindling: A possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis. Brain Res. 527: 1-6.
21. SUTULA, T. P. 1991. Reactive changes in epilepsy: Cell death and axon sprouting induced by kindling. Epilepsy Res. 10: 62-70.
22. CLARK, M., R. M. POST, S. R. B. WEISS & T. NAKAJIMA. 1992. Expression of c-fos mRNA in acute and kindled cocaine seizures in rats. Brain Res. 592: 101-106.
23. MORRELL, F. 1985. Secondary epileptogenesis in man. Arch. Neurol. 42: 318-335.
24. CHARNEY, D. S., A. Y. DEUTCH, J. H. KRYSTAL, S. M. SOUTHWCK & M. DAVIS. 1993. Psychobiologic mechanisms of posttraumatic stress disorder. Arch. Gen. Psychiatry 50: 294-305.
25. VAN DER KOLK, B. A., J. A. BURBRIDGE & J. SUZUKI. 1995. Current status of the psychobiology of posttraumatic stress disorder. Acta Neuropsychiatrica 7(Suppl. 3): S34-S37.
26. ROSEN, J. B., E. HAMERMAN, M. SITCOSKE, J. R. GLOWA & J. SCHULKIN. 1996. Hyperexcitability: Exaggerated fear-potentiated startle produced by partial amygdala kindling. Behav. Neurosci. 110: 43-50.
27. BEAULIEU, S., I. ROUSSE, A. GRATTON, N. BARDEN & J. ROCHFORD. 1994. Behavioral and endocrine impact of impaired type II glucocorticoid receptor function in a transgenic mouse model. Brain corticosteroid receptors: Studies on the mechanism, function and neurotoxicity of corticosteroid action. Ann. N.Y. Acad. Sci. 748: 388-391.
28. JOHN, E. R., Y. TANG, A. B. BRILL, R. YOUNG & K. ONO. 1986. Double-labeled metabolic maps of memory. Science 233: 1167-1175.
29. KIRKEGAARD, C., J. FABER, L. HUMMER & P. ROGOWSKI. 1979. Increased levels of TRH in cerebrospinal fluid from patients with endogenous depression. Psychoneuroendocrinology 4: 227-235.
30. BANKI, C. M., G. BISSETTE, M. ARATO & C. B. NEMEROFF. 1988. Elevation of immunoreactive CSF TRH in depressed patients. Am. J. Psychiatry 145: 1526-1531.
31. LOOSEN, P. T. 1985. The TRH-induced TSH response in psychiatric patients: A possible neuroendocrine marker. Psychoneuroendocrinology 10: 237-260.
32. WINOKUR, A. 1993. The thyroid axis and depressive disorders. In The Biology of Depressive Disorders. J. J. Mann & D. J. Kupfer, Eds.: 155-170. Plenum Press. New York, NY.
33. JOFFE, R. T. & T. H. SOKOLOV. 1994. Thyroid hormones, the brain, and affective disorders. Crit. Rev. Neurobiol. 8: 45-63.
34. BAUER, M. S. & P. C. WHYBROW. 1991. Rapid cycling bipolar disorder. Clinical features, treatment, and etiology. In Advances in Neuropsychiatry and Psychopharmacology, Vol. 2: Refractory Depression. J. D. Amsterdam, Ed.: 191-208. Raven Press. New York, NY.
35. PRANGE, A. J., JR., P. P. LARA, I. C. WILSON, L. B. ALLTOP & G. R. BREESE. 1972. Effects of thyrotropin-releasing hormone in depression. Lancet 2: 999-1002.
36. CALLAHAN, A. M., M. A. FRYE, L. B. MARANGELL, M. S. GEORGE, T. A. KETTER, T. L'HERROU & R. M. POST. 1996. Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: Confounding effects of tolerance and implications for therapeutics. Biol. Psychiatry 41: 264-272.
37. MARANGELL, L. B., M. S. GEORGE, A. M. CALLAHAN, T. A. KETTER, P. J. PAZZAGLIA, T. A. L'HERROU & R.M. POST. 1996. Effects of protirelin (thyrotropin-releasing hormone) in refractory depressed patients. Arch. Gen. Psychiatry 54: 212-214.
38. SMURTHWAITE, S., J. B. ROSEN, S. R. B. WEISS & R. M. POST. 1995. An assessment of the behavioral effects of thyrotropin-releasing hormone (abstract). Abstr. Soc. Neurosci. Mtng. 21(part 1): 757.
39. CAIN, D. P., F. BOON & E. L. HARGREAVES. 1992. Evidence for different neurochemical contributions to long-term potentiation and to kindling and kindling-induced potentiation: Role of NMDA and urethane-sensitive mechanisms. Exp. Neurol. 116: 330-338.
40. COSTA, E., J. AUTA, J. M. THOMPSON & A. GUIDOTTI. 1996. Positive allosteric modulation of AMPA or GABA, receptors antagonize alprazolam induced learning impairment in monkeys (abstr.). J. Eur. Coll. Neuropsychopharmacol. 6: 152.
41. YASUI, M. & K. KAWASAKI. 1995. CCKB receptor activation protects CA1 neurons from ischemia-induced dysfunction in stroke-prone spontaneously hypertensive rats hippocampal slices. Neurosci. Lett. 191: 99-102.
42. ADAMEC, R. 1995. Mechanisms of initiation and maintenance of increased generalized anxiety following traumatic stress. Presented at the Society for Neuroscience Meeting, 1995.
43. CAHILL, L., B. PRINS & J. L. MCGAUGH. 1994. Beta-adrenergic activation and memory for emotional events. Nature 371: 702-704.
44. WEISS, S. R. B., X. L. LI, J. B. ROSEN, H. LI, T. HEYNEN & R. M. POST. 1995. Quenching: Inhibition of development and expression of amygdala kindled seizures with low frequency stimulation. NeuroReport 6: 2171-2176.
45. WEISS, S. R. B., X.-L. LI, E. C. NOGUERA, T. HEYNEN, H. LI, J. B. ROSEN & R. M. POST. 1997. Quenching: Persistent alterations in seizure and afterdischarge threshold following low-frequency stimulation. In Kindling. V. M. Corcoran & S. Moshe, Eds. Plenum. New York, NY. In press.
46. GEORGE, M. S., E. M. WASSERMANN, W. A. WILLIAMS, A. CALLAHAN, T. A. KETTER, P. BASSER, M. HALLETT & R. M. POST. 1995. Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. NeuroReport 6: 1853-1856.
47. PASCUAL-LEONE, A., J. GRAFMAN, L. G. COHEN, B. J. ROTH & M. HALLETT. 1997. Transcranial magnetic stimulation: A new tool for the study of higher cognitive functions in man. In Handbook of Neuropsychology. J. Grafraan & E. Boller, Eds. Vol. 10. Elsevier. Amsterdam. In press.
48. HALLETT, M. 1996. Transcranial magnetic stimulation: A useful tool for clinical neurophysiology. Unpublished manuscript.
49. PASCUAL-LEONE, A., B. RUBIO, F. PALLARDO & M. D. CATALA. 1996. Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet 348: 233-237.
50. FOA, E. B. & D. S. RIGGS. 1993. Posttraumatic stress disorder and rape. In American Psychiatric Press Review of Psychiatry. J. M. Oldham, M. B. Riba & A. Tasman, Eds. Vol. 12: 273-303. American Psychiatric Press. Washington, D.C.