Protein kinase C-η regulates resistance to UV- and γ-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation

Neuro-Oncology

Volumn 4, Issue 1, 2002, Pages 9-21

  Hussaini, Isa M ^a   Carpenter, Joan E ^a   Redpath, Gerard T ^a   Sando, Julianne J ^a   Shaffrey, Mark E ^a   VandenBerg, Scott R ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 9; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE C; PROTEIN KINASE C ETA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ASTROCYTE; CELL DEATH; CONTROLLED STUDY; DIPLOIDY; DNA CONTENT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GAMMA RADIATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIVITY; TUMOR CELL; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

APOPTOSIS; ASTROCYTES; CASPASE 9; CASPASES; COLORING AGENTS; DNA; ENZYME ACTIVATION; GAMMA RAYS; GLIOBLASTOMA; HUMANS; ISOENZYMES; PROPIDIUM; PROTEIN KINASE C; STAINING AND LABELING; TRANSFECTION; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 0036203133     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/S1522851701000321     Document Type: Article

References (48)

1. Overexpression of protein kinase C-eta attenuates caspase activation and tumor necrosis factor-alpha-induced cell death
2. Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line
3. Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development
4. Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation
5. p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines
6. Protein kinase C: A worthwhile target for anticancer drugs?
7. Constitutional p53 mutations associated with brain tumors in young adults
8. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
9. Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines
10. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
11. Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
12. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines
13. Survival function of ERK 1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases
14. Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
15. Mammalian caspases: Structure, activation, substrates and functions during apoptosis
16. Expression of the p53 protein in a spectrum of astrocytic tumours
17. Activation of protein kinase Cδ in human myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine
18. Mitochondria and apoptosis
19. p53-dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma
20. Analysis of proliferation and apoptosis in brain gliomas: Prognostic and clinical value
21. Phorbol 12-myristate-13-acetate induces protein kinase Cη-specific proliferative response in astrocytic tumor cells
22. Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor
23. Brain tumors with cysts treated with Gamma Knife radiosurgery: Is microsurgery indicated?
24. Protein kinase Cι activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis
25. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
26. Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells
27. Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration
28. Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade
29. Cell cycle arrests and radiosensitivity of human tumor cell lines: Dependence on wild-type p53 for radiosensitivity
30. Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis
31. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
32. The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis
33. Effective treatment of experimental glioblastoma by HSV vectormediated TNFα and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration
34. Caspase-9 and Apaf-1 form an active holoenzyme
35. New insights into the regulation of protein kinase C and novel phorbol ester receptors
36. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
37. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
38. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
39. Activation of PKC alpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells
40. Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage
41. Two distinct pathways leading to nuclear apoptosis
42. Expression of apoptosis and its related protein in astrocytic tumors
43. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
44. Frequency of p53 tumor suppressor gene mutations in human primary brain tumors
45. Apoptosis in astrocytomas with different grades of malignancy
46. Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells
47. Ionizing radiation inhibits chemotherapy-induced apoptosis in cultured glioma cells: Implications for combined modality therapy
48. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9