Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate

Molecular and Cellular Biology

Volumn 20, Issue 20, 2000, Pages 7685-7692

  Urbe, S ^a   Mills, I G ^a   Stenmark, H ^a   Kitamura, N ^a   Clague, M J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; DYNAMIN; HEPATOCYTE GROWTH FACTOR REGULATED TYROSINE KINASE; PHOSPHATIDYLINOSITOL; PROTEIN TYROSINE KINASE; SCATTER FACTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENDOCYTOSIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANDROSTADIENES; ANIMAL; CELL LINE; CYTOSOL; ENDOCYTOSIS; ENDOSOMES; EPIDERMAL GROWTH FACTOR; FLUORESCENT ANTIBODY TECHNIQUE; HAMSTERS; HELA CELLS; HUMAN; MUTATION; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TRANSFECTION;

EID: 0033800735     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.20.7685-7692.2000     Document Type: Article

References (38)

1. Hrs is associated with STAM, a signal-transducing adaptor molecule
2. Isolation of yeast mutants defective in protein targeting to the vacuole
3. Hrs-2 is an ATPase implicated in calcium-regulated secretion
4. Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking
5. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
6. Membrane transport: Take your fusion partners
7. FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate
8. FYVE fingers bind PtdIns(3)P
9. Rab 5 controls early endosome fusion in vitro
10. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation
11. Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain
12. Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes
13. Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase
14. Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells
15. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
16. Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes
17. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p
18. EEA1, an early endosome-associated protein
19. A functional PtdIns(3)P-binding motif
20. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase
21. The role of phosphoinositide 3-kinase lipid products in cell function
22. Morphological classification of the yeast vacuolar protein sorting mutants: Evidence for a prevacuolar compartment in class E vps mutants
23. The effect of wortmannin on the localisation of lysosomal type 1 integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway
24. High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin
25. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin coated vesicles
26. The rab5 effector EEA1 interacts directly with syntaxin-6
27. EEA1 links PI(3)K function to tab5 regulation of endosome fusion
28. Receptor-mediated protein sorting to the vacuole in yeast: Roles for a protein kinase, a lipid kinase and GTP binding proteins
29. FYVE-finger proteins - Effectors of an inositol lipid
30. Rabaptin-5 is a direct effector of the small GTPase tab5 in endocytic membrane fusion
31. A hrs protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors
32. Distinct protein domains are responsible for the interaction of Hrs-2 with SNAP-25
33. SARA, a FYVE domain protein that recruits Smad2 to the TGFb receptor
34. Mutations in human dynamin block an intermediate stage in coated vesicle formation
35. Control of EGF receptor signaling by clathrin-mediated endocytosis
36. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
37. A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase
38. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways