Regulation of protein transport from the golgi complex to the endoplasmic reticulum by CDC42 and N-WASP

Molecular Biology of the Cell

Volumn 13, Issue 3, 2002, Pages 866-879

  Luna, Ana ^a   Matas, Olga B ^a   Martínez Menárguez, José Angel ^a   Mato, Eugenia ^a   Durán, Juan M ^a   Ballesta, José ^a   Way, Michael ^a   Egea, Gustavo ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COAT PROTEIN COMPLEX I; GUANOSINE TRIPHOSPHATASE; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN; PROTEIN CDC42; SHIGA TOXIN; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL LINE; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MICROINJECTIONS; NERVE TISSUE PROTEINS; PROTEIN TRANSPORT; RATS; RECEPTORS, PEPTIDE; RECOMBINANT FUSION PROTEINS; SHIGA TOXINS; TRANSPORT VESICLES; VIRAL ENVELOPE PROTEINS; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL;

ANIMALIA; MAMMALIA;

EID: 0036201054     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.01-12-0579     Document Type: Article

References (83)

1. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
2. Endocytic traffic in polarized epithelial cells: Role of the actin and microtubule cytoskeleton
3. Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport
4. Maintenance of CDC42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF. Evidence for Ras-GRF function being inhibited by Cdc42-GDP but unaffected by CDC42-GTP
5. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
6. COPII and selective export from the endoplasmic reticulum
7. Golgi spectrin: Identification of an erythroid beta-spectrin homolog associated with the Golgi complex
8. Palmitylation of viral membrane glycoproteins takes place after exit from the endoplasmic reticulum
9. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
10. The localization of myosin VI at the Golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation
11. Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
12. Selective control of basolateral membrane protein polarity by cdc42
13. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
14. Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes
15. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
16. Vesicle transport: The role of actin filaments and myosin motors
17. Morphological changes in the Golgi complex correlate with actin cytoskeleton rearrangements
18. Regulation of endocytic traffic by rho family GTPases
19. Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus
20. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCδ
21. Interactions between Rho GT-Pases and Rho GDP dissociation inhibitor (Rho-GDI)
22. Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signaling
23. Tyrosine phosphorylation is required for actin-based motility of vaccinia but not Listeria or Shigella
24. Developmental control of endocytosis in dendritic cells by Cdc42
25. ADP ribosylation factor regulates spectrin binding to the Golgi complex
26. ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex
27. CDC-42 controls early cell polarity and spindle orientation in C. elegans
28. Rho GTPases and the actin cytoskeleton
29. The potential role for CDC42 protein from rat brain cytosol in phospholipase D activation
30. Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles
31. Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
32. Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins
33. Surfing on a retrograde wave: How does Shiga toxin reach the endoplasmic reticulum?
34. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment
35. Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1
36. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells
37. Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments
38. Regulation of receptor-mediated endocytosis by Rho and Rac
39. Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum
40. The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42
41. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts
42. Direct pathway from early/recycling endosomes to the Golgi apparatus revealed through the study of shiga toxin B-fragment transport
43. Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles
44. Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with the cisternal progession model of intra-Golgi transport
45. Characterization of the association of the actin-binding protein, IQGAP, and activated Cdc42 with Golgi membranes
46. Actin-dependent regulation of neurotransmitter release at central synapses
47. A complex of N-WASP and WIP integrates signaling cascades that lead to actin polymerization
48. The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
49. Myosin II is involved in the production of constitutive transport vesicles from the TGN
50. Cdc42 regulates the exit of apical, and basolateral proteins from the trans-Golgi network
51. Rho GTPases control polarity, protrusion, and adhesion during cell movement
52. Fluorescence assays of Cdc42 interactions with target/effector proteins
53. Kinetics of Cdc42 membrane extraction by Rho-GDI monitored by real-time fluorescence resonance energy transfer
54. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex
55. Molecular links between endocytosis and the actin cytoskeleton
56. The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins
57. Rho proteins: Linking signaling with membrane trafficking
58. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
59. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate
60. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway
61. Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells
62. Phospholipase D as an effector for ADP-ribosylation factor in the regulation of vesicular traffic
63. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
64. Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum
65. Matrix proteins can generate the higher order architecture of the Golgi apparatus
66. The Wiskott-Aldrich syndrome protein (WASP): Roles in signaling and cytoskeletal organization
67. Recycling of Golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering
68. Breaking the COPI monopoly on Golgi recycling
69. Budding roles for myosin II on the Golgi
70. Regulation of the polarization of T cells toward antigen-presenting cells by Rasrelated GTPase CDC42
71. Wiskott-Aldrich ayndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
72. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
73. Actin filament nucleation by endosomes, lysosomes and secretory vesicles
74. Role of microtubules in the organization of the Golgi complex
75. Two pathways control chromaffin cell cortical F-actin dynamics during exocytosis
76. Actin microfilaments are essential for the cytological positioning and morphology of the Golgi complex
77. The Golgi-associated COPI-coated buds and vesicles contain β/γ-actin
78. Actin microfilaments facilitate the retrograde transport from the Golgi complex to the endoplasmic reticulum in mammalian cells
79. Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation
80. The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation
81. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
82. Regulation of actin polymerization in cell-free systems by GTPγS and Cdc42
83. How WASP regulates actin polymerization