Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice

Infection and Immunity

Volumn 69, Issue 2, 2001, Pages 838-844

  Khan, W I ^a   Vallance, B A ^a   Blennerhassett, P A ^a   Deng, Y ^a   Verdu, E F ^a   Matthaei, K I ^a   Collins, S M ^a  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; STAT6 PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHILIA; INTESTINE CONTRACTION; INTESTINE MUSCLE; MASTOCYTOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRICHINELLA SPIRALIS; TRICHINOSIS; WORM EXPULSION;

ANIMALS; EOSINOPHILIA; INTERLEUKIN-13; INTERLEUKIN-4; INTESTINES; LYMPH NODES; MICE; MICE, INBRED C57BL; MUSCLE CONTRACTION; SPLEEN; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRICHINELLA SPIRALIS; TRICHINOSIS;

EID: 0035140121     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.2.838-844.2001     Document Type: Article

References (45)

1. Induction of the expulsion of Strongyloides ratti and retension of Nippostrongylus brasiliensis in athymic nude mice by repetitive administration of recombinant interleukin-3
2. The roles of interleukins-4 and - IL-13, and Stat6 in inflammation-induced hypercontractility of murine isolated smooth muscle cells
3. v mice
4. Intrinsic jejunal propulsion in the guinea pig during parasitism with Trichinella spiralis
5. A critical role for IL-13 in resistance to intestinal nematode infection
6. Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent
7. Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris
8. Carbohydrates and lipids in Trichinella spiralis larvae and their utilization
9. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
10. Cooperation between interleukin-5 and the chemokine eotakine to induce eosinophil accommodation in vivo
11. The immunomodulation of enteric neuromuscular function: Implications for motility and inflammatory disorders
12. Induction of class II major histocompatilibity complex (MHC II) in enteric smooth muscle
13. Intestinal nematode parasites, cytokines and effector mechanisms
14. Propulsive activity of the rat small intestine during infection with the nematode Nippostrongylus brasiliensis
15. The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD)
16. 4 modulation of cholinergic neurotransmissio
17. Cloning and expression of murine immune interferon cDNA
18. L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice
19. Host protective immunity to Trichinella spiralis in mice: Activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes
20. The in vivo role of stem cell factor (c-kit ligand) on mastocytosis and host protective immunity to intestinal nematode Trichinella spiralis in mice
21. On the specificity of altered muscle function in experimental colitis in rats
22. Delayed expulsion of adult Trichinella spiralis by mast cell-deficient W/Wv mice
23. Depletion of eosinophils by anti IL-5 antibody treatment of mice infected with Trichinella spiralis does not alter parasite burden or immunological resistance to reinfection
24. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
25. Interleukin-4 receptor: Signaling mechanisms
26. Mucosal mast cells and the expulsive mechanisms of mice against Strongyloides venezuelensis
27. Identification of cytokine and adhesion molecule mRNA in murine lung tissue and isolated T cells and eosinophils by semiquantitative reverse transcriptase polymerase chain reaction
28. IL-4-regulated enteropathy in an intestinal nematode infection
29. Altered smooth muscle function in worm-free regions in Trichinella infected rats
30. Impaired development of Th2 cells in IL-13 deficient mice
31. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract
32. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
33. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice
34. The IL-4 receptor: Signaling mechanisms and biological functions
35. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody
36. Gut propulsion in mice infected with Trichinella spiralis
37. Essential role of Stat6 in IL-4 signalling
38. IL-13, IL-4R and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
39. Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell and T cell dependent mechanism
40. Expulsion of Nippostrongylus brasiliensis by mice deficient in mast cells
41. Increased intestinal muscle contractility and worm expulsion in nematode infected mice
42. CD4 T cells and major histocompatibility couple class II expression influence worm expulsion and increased intestinal muscle contraction during Trichinella spiralis infection
43. T lymphocytes dependent and independent intestinal smooth muscle dysfunction in the T. spiralis infected mouse
44. IL-5 contributes to worm expulsion and muscle hypercontractility in primary T. spiralis infection
45. Increased responsiveness of jejunal longitudinal muscle in Trichinella-infected rats