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Volumn 14, Issue 1, 2002, Pages 8-14

Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction

Author keywords

cGMP; Corpus cavernosum; Erectile dysfunction; Guanylate cyclase; Penile erection; Sildenafil; YC 1

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 6 ANILINO 5,8 QUINOLINEQUINONE; APOMORPHINE; CYCLIC GMP; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; ISOLIQUIRITIGENIN; METHYLENE BLUE; MINOXIDIL; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; TADALAFIL;

EID: 0036192244     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3900801     Document Type: Article
Times cited : (53)

References (55)
  • 2
  • 3
    • 0025162764 scopus 로고
    • Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung
    • (1990) J Biol Chem , vol.265 , pp. 16841-16845
    • Nakane, M.1
  • 5
  • 6
    • 0025942298 scopus 로고
    • Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme
    • (1991) FEBS Lett , vol.292 , pp. 217-222
    • Harteneck, C.1
  • 10
    • 0000000248 scopus 로고    scopus 로고
    • Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: Synergism of nitric oxide and YC-1
    • (2001) J Urol , vol.165 , Issue.SUPPL. 5 , pp. 223
    • Nakane, M.1
  • 11
    • 0022887257 scopus 로고
    • Soluble guanylate cyclase from rat lung exists as a heterodimer
    • (1986) J Biol Chem , vol.261 , pp. 7236-7241
    • Kamisaki, Y.1
  • 13
    • 0025296692 scopus 로고
    • Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic method
    • (1990) Eur J Biochem , vol.190 , pp. 273-278
    • Humbert, P.1
  • 14
    • 0029938767 scopus 로고    scopus 로고
    • Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase
    • (1996) Mol Pharmacol , vol.50 , pp. 1-5
    • Schrammel, A.1
  • 15
    • 0031985130 scopus 로고    scopus 로고
    • Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase
    • (1998) Br J Pharmacol , vol.123 , pp. 299-309
    • Olesen, S.P.1
  • 20
    • 0028929077 scopus 로고
    • Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta
    • (1995) Br J Pharmacol , vol.114 , pp. 1587-1594
    • Yu, S.M.1    Kuo, S.C.2
  • 23
    • 0029166002 scopus 로고
    • YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase
    • (1995) Br J Pharmacol , vol.116 , pp. 1973-1978
    • Wu, C.C.1
  • 24
    • 0031046943 scopus 로고    scopus 로고
    • Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators
    • (1997) Br J Pharmacol , vol.120 , pp. 681-689
    • Mulsch, A.1
  • 31
    • 0035826261 scopus 로고    scopus 로고
    • NO-independent regulatory site on soluble guanylate cyclase
    • (2001) Nature , vol.410 , pp. 212-215
    • Stasch, J.P.1
  • 34
    • 0346643472 scopus 로고    scopus 로고
    • Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity
    • (1999) Br J Pharmacol , vol.127 , pp. 195-203
    • Galle, J.1
  • 37
    • 0026659196 scopus 로고
    • Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum
    • (1992) J Urol , vol.147 , pp. 1650-1655
    • Bush, P.A.1
  • 38
  • 47
    • 0002689494 scopus 로고    scopus 로고
    • YC-1, a NO-independent guanylate cyclase stimulator, relaxes rabbit cavernous smooth muscle via increasing intracellular cyclic GMP
    • (2000) Int J Impot Res , vol.12 , Issue.SUPPL.
    • Liu, S.P.1
  • 48
    • 0028109332 scopus 로고
    • YC-1, a novel activator of platelet guanylate cyclase
    • (1994) Blood , vol.84 , pp. 4226-4233
    • Ko, F.N.1
  • 49
    • 0031565271 scopus 로고    scopus 로고
    • YC-1, a nitric-oxide independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice
    • (1997) Eur J Pharmacol , vol.320 , pp. 161-166
    • Teng, C.M.1
  • 52
    • 0034114153 scopus 로고    scopus 로고
    • Acute blood pressure effects of YC-1 induce activation of guanylate cyclase in normotensive and hypertensive rats
    • (2000) Br J Pharmacol , vol.130 , pp. 205-208
    • Rothermund, L.1
  • 53
    • 0033776013 scopus 로고    scopus 로고
    • Pathophysiology of erectile dysfunction: The contributions of trabecular structure to function and the role of functional antagonism
    • (2000) Int J Impot Res , vol.12 , Issue.SUPPL.
    • Moreland, R.B.1
  • 55
    • 0028260469 scopus 로고
    • Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: An in vitro study
    • (1994) Br J Urol , vol.74 , pp. 106-111
    • Miller, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.