Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells

Molecular Pharmacology

Volumn 59, Issue 2, 2001, Pages 220-224

  Schmidt, Kurt ^a   Schrammel, Astrid ^a   Koesling, Doris ^b   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; CYCLIC GMP; GUANYLATE CYCLASE; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; SWINE; THROMBOCYTE AGGREGATION;

EID: 0035133549     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.2.220     Document Type: Article

References (25)

1. Generation and characterization of a stable soluble guanylate cyclase-overexpressing CHO cell line
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Interaction of soluble guanylate cyclase with YC-1: Kinetic and resonance Raman studies
4. Mechanism of YC-1-induced activation of soluble guanylyl cyclase
5. YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets
6. Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme
7. Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity
8. Nitric oxide signaling in the central nervous system
9. G-methyl-Larginine causes endothelium-dependent contraction and inhibition of cGMP formation in artery and vein
10. Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic method
11. YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea
12. Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: A widespread signal transduction mechanism
13. Guanylyl cyclases, a growing family of signal transducing enzymes
14. Nitric oxide - Physiology, pathophysiology, and pharmacology
15. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators
16. Assay of tissue activity of nitric oxide synthase
17. Effect of calcium on endothelium-derived relaxing factor formation and cGMP levels in endothelial cells
18. Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin
19. Guanylate cyclase GTP pyropbosphate-lyase (cyclizing), E.C 4:6 1:2
20. Soluble guanylate cyclase: Effect of YC-1 on ligation kinetics with carbon monoxide
21. Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: Implications for the role of cleavage of the ironhistidine bond during activation by nitric oxide
22. 2+-dependent activation of endothelial nitric-oxide synthase
23. Mutation of His-105 in the β1-subunit yields a nitric oxideinsensitive fore of soluble guanylyl cyclase
24. Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase
25. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase