Stimulation of β3-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes

British Journal of Pharmacology

Volumn 135, Issue 4, 2002, Pages 951-960

  Mizuno, Katsushige ^a   Kanda, Yasunari ^a   Kuroki, Yasutomi ^a   Nishio, Masahiro ^a   Watanabe, Yasuhiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

3T3 L1 adipocytes; BRL37344A; CGP12177A; p38 MAPK; SR58611A; SR59230A

Indexed keywords

1 (2 ETHYLPHENOXY) 3 (1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINO) 2 PROPANOL OXALATE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 3 ADRENERGIC RECEPTOR; CHOLERA TOXIN; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PERTUSSIS TOXIN; PROPRANOLOL; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; [[7 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO] 5,6,7,8 TETRAHYDRO 2 NAPHTHYL]OXY]ACETIC ACID ETHYL ESTER;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 0036188718     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704537     Document Type: Article

References (49)

1. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoporterenol and govern activation properties in vitro
2. Atypicalβ-adrenoceptor on brown adipocytes as target for anti-obesity drugs
3. β-Adrenergic activation of p38 MAP kinase in adipocytes
4. 3-adrenergic receptor is required for MAP kinase activation
5. Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the α-subunit of the stimulatory guanine nucleotide-binding protein (Gs)
6. Mechanism of adenytate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site
7. Cholera toxin induces cAMP-independent degradation of Gs
8. 3-adrenergic receptors with Gi in rat adipocytes
9. Independent human MAP-kinase signal transduction pathway defined by MEK and MKK isoforms
10. 3-adrenergic receptor
11. Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis
12. 3-adrenoceptor antagonism by H89
13. 3-Adrenoceptors in the cardiovascular system
14. Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human Beta-adrenergic receptor: New Pharmacological profile and mechanism of activation
15. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptide corresponding to the active protein of the heat-stable inhibitor protein
16. 3-adrenergic receptor
17. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells
18. 3-selective agonist-induced effects on energy expenditure, insulin secration, and food intake
19. 3-adrenergic receptor
20. Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor
21. Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway
22. y/Ta diabetic obese mouse model
23. 3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes
24. Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus
25. 3-adrenergic receptors parallels lipolysis in rat adipocytes
26. 1-Adrenegic Erk 1/2 activation is src- but not Gi-mediated in brown adipocytes
27. Ambient temperature regulation of apoptosis in brown adipose tissue
28. Functional identification of rat atypical beta-adrenoceptors by the first beta3-selective antagonists, aryloxypropanolaminotetralins
29. 3-adrenergic receptors suppresses leptin expression and mediates a letpin-independent inhibition of food intake in mice
30. Cholera toxin treatment produces down-regulation of the α-subunit of the stimulatory guanine-nucleotide-binding protein (Gs)
31. 3-adrenoceptor
32. 3-adrenoceptor causes phosphorylation of extracellular signal-regulated kinases 1 and 2 through a Gs- but not Gi-dependent pathway in 3T3-L1 adipocytes
33. The activation of p38 MAPK by the β-adrenergic agonist isoproterenol in rat epididymal fat cells
34. 3-adrenergic receptor
35. 3-adrenergic receptor: Relationship with the atypical receptor of adipocytes
36. 3-adrenergic receptor antagonist SR59230A in rat brown adipocytes
37. mapk are required for fibroblast proliferation
38. Inhibition of MAP kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
39. Pharmacological inhibition of protein kinases in intact cells: Antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness
40. Forskolin: A unique diterpene activator of cyclic AMP-generating systems
41. Activation of mitogen-activated protein kinase by norepinephrine in brown adipocytes from rats
42. 3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism
43. 3-adrenergic receptor agonist for treating obesity and diabetes
44. 3-adrenergic receptor gene
45. Pertussis toxin-sensitive activation of p21 ras by G protein-coupled receptor agonists in fibroblasts
46. Multiple beta-adrenergic receptor subclasses mediate the L-isoproterenol-induced lipolytic response in rat adipocytes
47. Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices
48. Inhibition of Ns-stimulated human platelet adenylate cyclase by forskolin
49. 3-adrenoceptor agonists in Humans