Analysis of inhibition by H89 of UCP1 gene expression and thermogenesis indicates protein kinase A mediation of β3-adrenergic signalling rather than β3-adrenoceptor antagonism by H89

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1538, Issue 2-3, 2001, Pages 206-217

  Fredriksson, J M ^a   Thonberg, Håkan ^a   Ohlson, Kerstin B E ^a   Ohba, Ken ichi ^a   Cannon, Barbara ^a   Nedergaard, Jan ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Brown adipocyte; N 2 (p Bromocinnamylamino)ethyl 5 isoquinolinesulfonamide; Protein kinase A; Thermogenesis; Uncoupling protein 1; 3 Adrenoceptor

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NORADRENALIN; UNCOUPLING PROTEIN 1;

ADRENERGIC STIMULATION; ANIMAL CELL; ARTICLE; BROWN ADIPOSE TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; MALE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THERMOGENESIS;

ADIPOCYTES; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYME INHIBITORS; FORSKOLIN; GENE EXPRESSION REGULATION; ION CHANNELS; ISOQUINOLINES; MEMBRANE PROTEINS; MICE; MITOCHONDRIAL PROTEINS; NOREPINEPHRINE; OXYGEN CONSUMPTION; RECEPTORS, ADRENERGIC, BETA-3; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 0035938181     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(01)00070-2     Document Type: Article

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