Induction of anti-GBM nephritis in rats by recombinant α3(IV)NC1 and α4(IV)NC1 of type IV collagen

Kidney International

Volumn 53, Issue 3, 1998, Pages 664-671

  Sado, Yoshikazu ^a   Boutaud, Ariel ^b   Kagawa, Megumi ^b   Naito, Ichiro ^b   Ninomiya, Yoshifumi ^b   Hudson, Billy G ^b  

^a Shigei Medical Research Institute and Hospital   (Japan)

^b NONE

Author keywords

Anti GBM nephritis; Glomerular basement membrane; Glomerulonephritis; Recombinant protein; Type IV collagen

Indexed keywords

COLLAGEN TYPE 4; GLOMERULUS BASEMENT MEMBRANE ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CAPILLARY BASEMENT MEMBRANE; FEMALE; GOODPASTURE SYNDROME; NEPHRITIS; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0031939068     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00795.x     Document Type: Article

References (34)

1. SCHEER RL, GROSSMAN MA: Immune aspects of the glomerulonephritis associated with pulmonary hemorrhage. Ann Int Med 60: 1009, 1964
2. LERNER RA, DIXON FJ: Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J Exp Med 124:431-442, 1966
3. LERNER RA, GLASSOCK RJ, DIXON FJ: The role of antiglomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med 126:989-1004, 1967
4. BUTKOWSKI RJ, LANGEVELD JP, WIESLANDER J, HAMILTON J, HUDSON BG: Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J Biol Chem 262:7874-7877, 1987
5. SAUS J, WIESLANDER J, LANGEVELD JP, QUINONES S, HUDSON BG: Identification of the Goodpasture antigen as the alpha 3(IV) chain of collagen IV. J Biol Chem 263:13374-13380, 1988
6. HUDSON BG, REEDERS ST, TRYGGVASON K: Type IV collagen: Structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. J Biol Chem 268:26033-26036, 1993
7. KALLURI R, WILSON CB, WEBER M, GUNWAR S, CHONKO AM, NEILSON EG, HUDSON BG: Identification of the α3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome. J Am Soc Nephrol 6:1178-1185, 1995
8. DEHAN P, WEBER M, ZHANG X, REEDERS ST, FOIDART JM, TRYGGVASON K: Sera from patients with anti-GBM nephritis including Goodpasture syndrome show heterogeneous reactivity to recombinant NC1 domain of type IV collagen chains. Nephrol Dial Transplant 11:2215-2222, 1976
9. SADO Y, OKIGAKI T, TAKAMIYA H, SENO S: Experimental autoimmune glomerulonephritis with pulmonary hemorrhage in rats. The dose-effect relationship of the nephritogenic antigen from bovine glomerular basement membrane. J Clin Lab Immunol 15:199-204, 1984
10. SADO Y, KAGAWA M, KISHIRO Y, NAITO I, JOH K, NINOMIYA Y: Purification and characterization of human nephritogenic antigen that induces anti-GBM nephritis in rats. J Pathol (in press)
11. SADO Y, NAITO I: Experimental autoimmune glomerulonephritis in rats by soluble isologous or homologous antigens from glomerular and tubular basement membranes. Br J Exp Pathol 68:695-704, 1987
12. SUGIHARA K, SADO Y, NINOMIYA Y, WADA H: Experimental antiGBM glomerulonephritis induced in rats by immunization with synthetic peptides based on six α chains of human type IV collagen. J Pathol 178:352-358, 1996
13. KALLURI R, GATTONE VH II, NOELKEN ME, HUDSON BG: The α3 chain of type IV collagen induces autoimmune Goodpasture syndrome. Proc Natl Acad Sci USA 91:6201-6205, 1994
14. NEILSON EG, KALLURI R, SUN MJ, GUNWAR S, DANOFF T, MARIYAMA M, MYERS JC, REEDERS ST, HUDSON BG: Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen. J Biol Chem 268:8402-8405, 1993
15. LEINONEN A, MARIYAMA M, MOCHIZUKI T, TRYGGVASON K, REEDERS ST: Complete primary structure of the human type IV collagen α4(IV) chain. J Biol Chem 269:26172-26177, 1994
16. HOSTIKKA SL, EDDY RL, BYERS MG, HÖYHTYA M, SHOWS TB, TRYGGVASON K: Identification of a distinct type IV collagen a chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome. Proc Natl Acad Sci USA 87:1606-1610, 1990
17. SOININEN R, HAKA RISKU T, PROCKOP DJ, TRYGGVASON K: Complete pryimary structure of the α1-chain of human basement membrane (type IV) collagen. FEBS Lett 225:188-194, 1987
18. HOSTIKKA SL, TRYGGVASON K: The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain. J Biol Chem 263:19488-19493, 1988
19. OOHASHI T, SUGIMOTO M, MATTEI MG, NINOMIYA Y: Identification of a new collagen IV chain, alpha 6(IV), by cDNA isolation and assignment of the gene to chromosome Xq22, which is the same locus for COL4A5. J Biol Chem 269:7520-7526, 1994
20. BURNETTE WH: Western blotting: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 112:195-203, 1981
21. LAEMMLI UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
22. SADO Y, KAGAWA M, NAITO I, OKIGAKI T: Properties of bovine nephritogenic antigen that induces anti-GBM nephritis in rats and its similarity to the Goodpasture antigen. Virchows Arch 60:345-351, 1991
23. GUNWAR S, BALLESTER F, KALLURI R, TIMONEDA J, CHONKO AM, EDWARDS SJ, NOELKEN ME, HUDSON BG: Glomerular basement membrane. Identification of dimeric subunits of the noncollagenous domain (hexamer) of collagen IV and the Goodpasture antigen. J Biol Chem 266:15318-15324, 1991
24. NINOMIYA Y, KAGAWA M, IYAMA K, NAITO I, KISHIRO Y, SEYER JM, SUGIMOTO M, OOHASHI T, SADO Y: Differential expression of two basement membrane collagen genes, COL4A6 and COL4A5, demonstrated by immunofluorescence staining using peptide-specific monoclonal antibodies. J Cell Biol 130:1-11, 1995
25. STEBLAY RW: J Exp Med 116:253-271, 1962
26. BYGREN P, WIESLANDER J, HEINEGARD D: Glomerulonephritis induced in sheep by immunization with human glomerular basement membrane. Kidney Int 31:25-31, 1987
27. HUDSON BG, KALLURI R, GUNWAR S, WEBER M, BALLESTER F, HUDSON JK, NOELKEN ME, SARRAS M, RICHARDSON WR, SAUS J: The pathogenesis of Alport syndrome involves type IV collagen molecules containing the alpha 3(IV) chain: Evidence from anti-GBM nephritis after renal transplantation. Kidney Int 42:179-187, 1992
28. KALLURI R, WEBER M, NETZER KO, SUN MJ, NEILSON EG, HUDSON BG: COL4A5 gene deletion and production of post-transplant antialpha 3(IV) collagen alloantibodies in Alport syndrome. Kidney Int 45:721-726, 1994
29. KLEPPEL MM, FAN WW, CHEONG HI, KASHTAN CE, MICHAEL AF: Immunochemical studies of Alport antigen. Kidney Int 41:1629-1637, 1992
30. DING J, KASHTAN CE, FAN WW, KLEPPEL MM, SUN MJ, KALLURI R, NEILSON EG, MICHAEL AF: A monoclonal antibody marker for Alport syndrome identifies the Alport antigen as the α5 chain of type IV collagen. Kidney Int 46:1504-1506, 1994
31. DEHAN P, VAN DEN HEUVEL LP, SMEETS HJ, TRYGGVASON K, FOIDART JM: Identification of post-transplant anti-alpha 5 (IV) collagen alloantibodies in X-linked Alport syndrome. Nephrol Dial Transplant 11:1983-1988, 1996
32. th International Symposium in Basement Membranes, Boston 1997
33. PEISSEL B, GENG L, KALLURI R, KASHTAN C, RENNKE HG, GALLO GR, KAZUO Y, SUN MJ, HUDSON BG, NEILSON EG, ZHOU J: Comparative distribution of the α1(IV), a5(IV), and α6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients. J Clin Invest 96:1948-1957, 1995
34. JOHANSSON C, BUTKOWSKI R, WIESLANDER J: The structural organization of type IV collagen. Identification of three NC1 populations in the glomerular basement membrane. J Biol Chem 267:24533-24537, 1992