Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor

European Journal of Immunology

Volumn 32, Issue 2, 2002, Pages 568-575

  Di Bartolo, Vincenzo ^a   Malissen, Marie ^b   Dufour, Evelyne ^a   Sechet, Emmanuel ^a   Malissen, Bernard ^b   Acuto, Oreste ^a  

^a INSTITUT PASTEUR   (France)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

ITAM; Signal transduction; TCR; Vav 1; ZAP 70

Indexed keywords

CD3 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RECEPTOR SUBUNIT; T LYMPHOCYTE RECEPTOR; TYROSINE; VAV PROTEIN;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CELL SELECTION; ENZYME BINDING; ENZYME STRUCTURE; GENE MUTATION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THYMOCYTE;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TYROSINE; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0036176840     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200202)32:2<568::AID-IMMU568>3.0.CO;2-Q     Document Type: Article

References (44)

1. Signal transduction by lymphocyte antigen receptors
2. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
3. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
4. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCRζ/CD3 induction of interleukin-2
5. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T cell receptor function
6. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
7. Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70
8. Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling
9. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function
10. Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function
11. Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70
12. Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T cell receptor signaling pathways
13. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-vav
14. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the SH2 domain of Lck
15. Phosphorylation of Tyr319 in ZAP-70 is required for T cell antigen receptor-dependent phospholipase C-gamma 1 and Ras activation
16. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70
17. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70
18. Cbl: Complex formation and functional implications
19. The product of the proto-oncogene c-Cbl: A negative regulator of the Syk tyrosine kinase
20. The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells
21. The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction
22. Fyn and ZAP-70 are required for Vav phosphorylation in T cell stimulated by antigen-presenting cells
23. T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase
24. Tissue hyperplasia and enhanced T cell signalling via ZAP-70 in c-Cbl-deficient mice
25. Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes
26. Altered thymic positive selection and intracellular signals in Cbl-deficient mice
27. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes
28. Purification and characterization of human ZAP-70 protein-tyrosine kinase from a baculovirus expression system
29. + thymocytes with limiting p56lck
30. Dominant-negative Zeta-associated protein 70 inhibits T cell antigen receptor signaling
31. Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions
32. Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes
33. Genetic evidence for differential coupling of Syk family kinases to the T cell receptor: Reconstitution studies in a ZAP-70-deficient Jurkat T cell line
34. Binding of ZAP-70 to phosphorylated T cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins
35. Phosphorylation of human erythrocyte band 3 by endogenous p72syk
36. Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding
37. Vav is a regulator of cytoskeletal reorganization mediated by the T cell receptor
38. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
39. A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling
40. Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides
41. Tolerance induction in double specific T cell receptor transgenic mice varies with antigen
42. T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-ζ association
43. Microinjected antibodies against the cytoplasmique domain of vesicular stomatitis virus glycoprotein block its transport to the cell surface
44. High-efficiency transformation of mammalian cells by plasmid DNA