Frequent microsatellite instability and loss of heterozygosity in the region including BRCA1 (17q21) in young patients with gastric cancer

International Journal of Oncology

Volumn 12, Issue 6, 1998, Pages 1245-1251

  Semba, Shuho ^a   Yokozaki, Hiroshi ^a   Yasui, Wataru ^a   Tahara, Eiichi ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

BRCA1; Early onset gastric cancer; Microsatellite instability

Indexed keywords

MICROSATELLITE DNA; PROTEIN P53;

ADULT; ARTICLE; BASE MISPAIRING; CLINICAL ARTICLE; DNA REPLICATION; FEMALE; HETEROZYGOSITY LOSS; HUMAN; MALE; MICROSATELLITE INSTABILITY; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC MUTATION; STOMACH ADENOCARCINOMA; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR SUPPRESSOR GENE;

EID: 0031814366     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.12.6.1245     Document Type: Article

References (39)

1. Tahara E: Molecular mechanism of stomach carcinogenesis. J Cancer Res Clin Oncol 119: 265-272, 1993.
2. Tahara E, Semba S and Tahara H: Molecular biological observation in gastric cancer. Semin Oncol 23: 307-315, 1996.
3. Grabiec J and Owen DA: Carcinoma of the stomach in young persons. Cancer 56: 388-396, 1985.
4. Kinzler KW and Vogelstein B: Lessons from hereditary colorectal cancer. Cell 87: 159-170, 1996.
5. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M and Molodner R: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038, 1993.
6. Papadopoulos N, Nicolaides NC, Wei Y-F, Ruben SM, Carter KC, Rosen, CA, Haseltine WA, Fleischmann RD, Frase CM, Adams MD,Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomaki P, Mecklin J-P, Chapelle A, Kinzler KW and Vogelstein B: Mutation of a mutL homolog in hereditary colon cancer. Science 263: 1625-1629, 1994.
7. Wooster R, Cleton-Jansen A-M, Collins N, Mangion J, Cornelis RS, Cooper CS, Guterson BA, Ponder BAJ, von Demiling A, Wistler OD, Cornelisse CJ, Devilee P and Stratton MR: Instability of short tandem repeats (microsatellites) in human cancers. Nat Gen 6: 152-156, 1994.
8. Semba S, Yokozaki H, Yamamoto S, Yasui W and Tahara E: Microsatellite instability in precancerous lesions and adenocarcinomas of the stomach. Cancer 77: 1620-1627, 1996.
9. Stricker JG, Zheng J, Shu Q, Burgart LJ, Alberts SR and Shibata D: p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res 54: 4750-4755, 1994.
10. Fong KM, Zimmerman PV and Smith PJ: Microsatellite instability and other molecular abnormalities in non-small cell lung cancer. Cancer Res 55: 28-30, 1996.
11. Horii A, Han H-J, Shimada M, Yanagisawa A, Kato Y, Ohta H, Yasui W, Tahara E and Nakamura Y: Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers. Cancer Res 54: 3373-3375, 1994.
12. Liu B, Farrington SM, Petersen GM, Hamilton SR, Parsons R, Papadopoulos N, Fujiwara T, Jen J, Kinzler Kw, Wyllie AH, Vogelstein, B and Dunlop MG: Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1: 348-352, 1995.
13. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
14. Hollstein M, Rice K, Greenblatt MS, Soussi T, Fuchs R, Sorlie T, Hoving E, Smith-Sorensen B, Montesano R and Harris CC: Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res 22: 3551-3555, 1994.
15. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal, J, Hussey, C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Steven N, Bristow PK, Norris FH, Helvering L, Morrison S, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kramb A and Skilnick MH: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71, 1994.
16. Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, Bennett LM, Haugen-Strano A, Swensen J, Miki Y, Eddington K, McClure M, Frye C, Weaver-Feldhaus J, Ding W, Gholami Z, Soderkvist P, Terry L, Jhanwar S, Berchuck A, Iglehart JD, Marks J, Ballinger DJ, Barrett JC, Skolnick MH, Kamb A and Wiseman R: BRCA1 mutations in primary breast and ovarian carcinomas. Science 266: 120-123, 1994.
17. Japanese Research Society for Gastric Cancer: Japanese classification of gastric carcinoma. First English edition. Kanehara & Co., Ltd., Tokyo, 1995.
18. Neuhausen SL and Marshall CJ: Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res 54: 6069-6072, 1994.
19. Markowits S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbauch J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M and Willson JKV: Inactivation of the type II TGF-ß receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338, 1995.
20. Myeroff LL, Parsons R, Kim S-J, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbauch J, Park K, Bang Y-J, Lee HY, Park J-G, Lynch HT, Roberts AB, Vogelstein B and Markowitz SD: A transforming growth factor β type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 55: 5545-5547, 1995.
21. Kobayashi K, Matsushima M, Koi S, Saito H, Sagae S, Kudo R and Nakamura Y: Mutational analysis of mismatch repair genes, hMLH1 and HMSH2, in sporadic endometrial carcinomas with microsatellite instability. Jpn J Cancer Res 87: 141-145, 1996.
22. Han H-J, Maruyama M, Baba S, Park J-G and Nakamura Y: Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Hum Mol Genet 2: 237-242, 1995.
23. Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE and King M-C: Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat Genet 8: 399-404, 1994.
24. WAF1/CIP1 in non-neoplastic mucosa and neoplasia of the stomach: relationship with p53 status and proliferative activity. J Pathol 180: 122-128, 1996.
25. Sekine I, Yokose T, Ogura T, Suzuki K, Nagai K, Kodama T, Mukai K, Nishiwaki Y and Esumi H: Microsatellite instability in lung cancer patients 40 years of age or younger. Jpn J Cancer Res 88: 559-563, 1997.
26. Akiyama Y, Nagasaki H, Nihei Z, Iwama T, Nomizu T, Utsunomiya J and Yuasa Y: Frequent microsatellite instabilities and analysis of the related genes in familial gastric cancers. Jpn J Cancer Res 87: 595-601, 1996.
27. Sano T, Tsujino T, Yoshida K, Nakayama H, Haruma K, Ito H, Nakamura Y, Kajiyama G and Tahara E: Frequent loss of heterozygosity on chromosome 1q, 5q, and 17p in human gastric carcinomas. Cancer Res 51: 2926-2931, 1991.
28. Kuniyasu H, Yasui W, Yokozaki H, Akagi M, Akama Y, Kitahara K, Fujii K and Tahara E: Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas. Int J Cancer 59: 597-600, 1994.
29. Uchino S, Tsuda H, Noguchi M, Yokota J, Terada M, Saito T, Kobayashi M, Sugimura T and Hirohashi S: Frequent loss of heterozygosity at the DCC locus in gastric cancer. Cancer Res 52: 3099-3102, 1992.
30. Baffa R, Negrini M, Mandes B, Rugge M, Ranzani GN, Hirohashi S and Croce C: Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach. Cancer Res 56: 268-272, 1996.
31. Monterio AN, August A and Hanafusa H: Evidence for a trans-criptional activation of BRCA1 C-terminal region. Proc Natl Acad Sci USA 93: 13595-13599, 1996.
32. Chen Y, Farmer AA, Chen C-F, Jones DC, Chen P-L and Lee W-H: BRCA1 is a 220 kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res 56: 3168-3172, 1996.
33. Marks JR, Huper G, Vaughn JP, Davis PL, Norris J, McDonnell DP, Wiseman RW, Futreal PA and Iglehart JD: BRCA1 expression is not directly responsive to estrogen. Oncogene 14: 115-121, 1997.
34. Miki Y, Katagiri T, Kasumi F, Yoshimoto T and Nakamura Y: Mutation analysis in the BRCA2 gene in primary breast cancers. Nat Genet 13: 245-247, 1996.
35. Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C and Micklem G: Identification of the breast cancer susceptibility gene, BRCA2. Nature 378: 789-792, 1995.
36. Mori T, Aoki T, Matsubara T, Iida F, XiQun D, Nishihara T, Mori S and Nakamura Y: Frequent loss of heterozygosity in the region including BRCA1 on chromosome 17q in squamous cell carcinoma of the esophagus. Cancer Res 54: 1638-1640, 1994.
37. Rajan JV, Wang M, Marquis ST and Chodosh LA: Brca2 is coordinately regulated with Brcal during proliferation and differentiation in mammary epithelial cells. Proc Natl Acad Sci USA 93: 13078-13083, 1996.
38. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T and Livingston DM: Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88: 265-275, 1997.
39. Sharan SK, Morimatsu M, Albrecht U, Lim D-S, Regel E, Dinh C, Sands A, Eichele G and Bradley A: Embryonic lethality and radiation hyper-sensitivity mediated by Rad51 in mice lacking Brca2. Nature 386: 804-810, 1997.