Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia

Annals of Hematology

Volumn 76, Issue 3-4, 1998, Pages 101-110

  Stilgenbauer, S ^a   Dohner K ^a   Bentz, M ^a   Lichter, P ^b   Dohner H ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

11q22 q23; B CLL; Chromosome abnormalities; FISH; Prognostic factors; TP53

Indexed keywords

B CELL LEUKEMIA; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME 6Q; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME BANDING PATTERN; CHRONIC LYMPHATIC LEUKEMIA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE TRANSLOCATION; GENETIC ANALYSIS; HUMAN; INTERPHASE; MITOSIS RATE; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK ASSESSMENT; TRISOMY; TUMOR SUPPRESSOR GENE;

CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 6; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, B-CELL, CHRONIC;

EID: 0031976628     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050373     Document Type: Review

References (99)

1. Adachi M, Cossman J, Longo D, Croce CM. Tsujimoto Y (1989) Variant translocation of the bcl-2 gene to immunoglobulin lambda light chain gene in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 86:2771-2774
2. Anastasi J. Le Beau MM, Vardiman JW, Fernald AA, Larson RA, Rowley JD (1992) Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method. Blood 79:1796-1801
3. Arif M, Tanaka K, Asou H, Ohno R, Kamada N (1995) Independent clones of trisomy 12 and retinoblastoma gene deletion in Japanese B cell chronic lymphocytic leukemia, detected by fluorescence in situ hybridization. Leukemia 9:1822-1827
4. Autio K, Turunen O, Penttilä O, Erämaa E, de la Chapelle A, Schröder J (1979) Human chronic lymphocytic leukemia: karyotypes in different lymphocyte populations. Cancer Genet Cytogenet 1:147-155
5. Autio K, Elonen E, Teerenhovi L, Knuutila S (1986) Cytogenetic and immunologic characterization of mitotic cells in chronic lymphocytic leukemia. Eur J Haematol 39:289-298
6. Bentz M, Huck K, du Manoir S, Joos S, Werner CA, Fischer K, Döhner H, Lichter P (1995) Comparative genomic hybridization in chronic B-cell leukemias reveals a high incidence of chromosomal gains and losses. Blood 85:3610-3618
7. Bird ML, Ueshima Y, Rowley JD, Haren JM, Vardiman JW (1989) Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations. Leukemia 3:182-191
8. Bloomfield CD, Arthur DC, Frizzera G, Levine EG, Peterson BA. Gajl-Peczalska KJ (1983) Nonrandom chromosome abnormalities in lymphoma. Cancer Res 43:2975-2984
9. Bosch F. Jares P, Campo E, Lopez-Guilllermo A, Piris MA, Villamor N. Tassies D, Jaffe SE, Montserrat E, Rozman C, Cardesa A (1994) PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma. Blood 84:2726-2732
10. Bouyge-Moreau I, Rondeau G, Avet-Loiseau H, André M-T, Bézieau S, Chérel M, Saleün S, Cadoret E, Shaikh T, De Angelis MM, Arcot S, Batzer M, Moisan J-P, Devilder M-C (1997) Construction of a 780-kb PAC, BAC, and cosmid contig encompassing the minimal critical deletion involved in B cell chronic lymphocytic leukemia at 13q14.3. Genomics 46:183-190
11. Brown AG, Ross FM, Dunne EM, Steel EM, Weir-Thompson EM (1993) Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene. Nature Genet 3:67-72
12. Bullrich F, Veronese ML, Kitada S, Jurlander J, Caligiuri MA, Reed JC, Croce CM (1996) Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia. Blood 88:3109-3115
13. Callen DF, Ford JH (1983) Chromosome abnormalities in chronic lymphocytic leukemia revealed by TPA as a mitogen. Cancer Genet Cytogenet 10:87-93
14. Chapman RM, Corcoran MM, Gardiner A, Hawthorn LA, Cowell JK, Oscier DG (1994) Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia. Oncogene 9:1289-1293
15. Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O'Brien S, Rai KR (1996) National Cancer Institute-Sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87:4990-4997
16. Cremer T, Landegent J, Brückner A, Scholl HP, Schardin M, Hager HD, Devilee P, Pearson PP, van der Ploeg M (1986) Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84. Hum Genet 74:346-352
17. Criel A, Wlodarska I, Meeus P, Stul M, Louwagie A, van Hoof A, Hidajat M, Mecucci C, van den Berghe H (1994) Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias. Br J Haematol 87:523-528
18. Crossen PE, Morrison MJ (1993) Lack of 5′ BCL2 rearrangements in B-cell leukemia. Cancer Genet Cytogenet 69:72-73
19. Devilder MC, François S, Bosic C, Moreau A, Mellerin MP, Le Paslier D, Bataille R, Moisan JP (1995) Deletion cartography around the D13S25 locus in B cell chronic lymphocytic leukemia. Cancer Res 55:1355-1357
20. Dierlamm J, Wlodarska I, Michaux L, Vermeesch JR, Meeus P, Stul M, Criel A, Verhoef G, Thomas J, Delannoy A, Louwagie A, Cassiman JJ, Mecucci C, Hagemeijer A, Van den Berghe H (1997) FISH identifies different types of duplications with 12q13-15 as the commonly involved segment in B-cell lymphoproliferative malignancies characterized by partial trisomy 12. Genes Chrom Cancer 20:155-166
21. Döhner H, Pohl S, Bulgay-Mörschel M, Stilgenbauer S, Bentz M, Lichter P (1993) Detection of trisomy 12 in chronic lymphoid leukemias using fluorescence in situ hybridization. Leukemia 7:516-520
22. Döhner H, Pilz T, Fischer K, Cabot G, Diehl D, Fink T, Stilgenbauer S, Bentz M, Lichter P (1994) Molecular cytogenetic analysis of Rb-1 deletions in chronic B-cell leukemias. Leuk Lymphoma 16:97-103
23. Döhner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G, Diehl D, Schlenk R, Coy J, Stilgenbauer S, Volkmann M, Galle PR, Poustka A, Hunstein W, Lichter P (1995) p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 85:1580-1589
24. Döhner H, Stilgenbauer S, Fischer K, Bentz M, Lichter P (1997) Cytogenetic and molecular cytogenetic analysis of B cell chronic lymphocytic leukemia: specific chromosome aberrations identify prognostic subgroups of patients and point to loci of candidate genes. Leukemia 11 [Suppl 2]: 19-24
25. Döhner H, Stilgenbauer S, James MR, Benner A, Bentz M, Fischer K, Hunstein W, Lichter P (1997) 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 89:2516-2522
26. Dyer MJ, Zani VJ, Lu WZ, O'Byrne A, Mould S, Chapman R, Heward JM, Kayano H, Jadayel D, Matutes E, Catovsky D. Oscier DG (1994) BCL2 translocations in leukemias of mature B cells. Blood 83:3682-3688
27. Einhorn S, Burvall K, Juliusson G, Gahrton G, Meeker T (1989) Molecular analysis of chromosome 12 in chronic lymphocytic leukemia. Leukemia 3:871-874
28. El Rouby S, Thomas A, Costin D, Rosenberg CR, Potmesil M, Silber R, Newcomb EW (1993) p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood 82:3452-3459
29. Escudier SM, Pereira-Leahy JM, Drach JW, Weier HU, Goodacre AM, Cork MA, Trujillo JM, Keating MJ, Andreeff M (1993) Fluorescence in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia. Blood 81:2702-2707
30. Fegan C, Robinson H, Thompson P, Whittaker JA, White D (1995) Karyotypic evolution in CLL. Identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease. Leukemia 9:2003-2008
31. Fenaux P, Preudhomme C, Laï JL, Quiquandon I, Jonveaux P, Vanrumbeke M, Sartiaux C, Morel P, Loucheux-Lefebvre MH, Bauters F, Berger R, Kerckaert P (1992) Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis. Leukemia 6:246-250
32. Fitchett M, Griffiths MJ, Oscier DG, Johnson S, Seabright M (1987) Chromosome abnormalities involving band 13q14 in hematologic malignancies. Cancer Genet Cytogenet 24:143-150
33. Gahrton G, Robèrt KH. Friberg K, Zech L, Bird AG (1980) Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation. Blood 56:640-647
34. Gahrton G, Robèrt KH, Friberg K, Juliusson G, Biberfeld P, Zech L (1982) Cytogenetic mapping of the duplicated segment of chromosome 12 in lymphoproliferative disorders. Nature 297:513-514
35. Gaidano G, Ballerini P, Gong JZ, Inghirami G, Neri A, Newcomb EW, Magrath IT, Knowles DM, Dalla-Favera R (1991) p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 88:5413-5417
36. Gaidano G, Newcomb EW, Gong JZ, Tassi V, Neri A, Cortelezzi A, Calori R, Baldini L, Dalla-Favera R (1994) Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia. Am J Pathol 144:1312-1319
37. Garcia-Marco JA, Caldas C, Price CM, Wiedemann LM, Ashworth A, Catovsky D (1996) Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia. Blood 88:1568-1575
38. Geisler CH, Philip P, Egelund Christensen B, Hou-Jensen K, Tinggaard Peterson N, Myhre Jensen O, Thorling K, Andersen E, Birgens HS, Drivsholm A, Ellegaard J, Larsen JK, Plesner T, Brown P, Kragh Andersen P, Mørk Hansen M (1997) In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients. Leukemia Res 21:1011-1023
39. Han T, Ozer H, Sadamori N, Emrich L, Gomez GA, Henderson ES, Bloom JL, Sandberg AA (1984) Prognostic importance of cytogenetic abnormalities in patients with chronic lymphocytic leukemia. N Engl J Med 310:288-292
40. Han T, Sadamori N, Block AMW, Xiao H, Henderson ES, Emrich L, Sandberg AA (1988) Cytogenetic studies in chronic lymphocytic leukemia, prolymphocytic leukemia and hairy cell leukemia: a progress report. Nouv Rev Fr Hematol 30:393-395
41. Kanada M, Delia D, Aiello A, Stadtmauer E, Reed JC (1993) BCL2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 82:1820-1828
42. Hernandez JM, Mecucci C, Criel A, Meeus P, Michaux L, van Hoof A. Verhoef G, Louwagie A, Scheiff JM, Michaux JL, Boogaerts M, van den Berghe H (1995) Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphological and immunophenotypic (FAB) criteria. Leukemia 9:2140-2146
43. Hurley JN, Fu SM, Kunkel HG, Chaganti RSK, German L (1980) Chromosome abnormalities of leukaemic B-lymphocytes in chronic lymphocytic leukaemia. Nature 283:76-78
44. James MR, Richard III CW, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A, Agrapart M, Imai T, Nakamura Y, Polymeropoulos M, Weissenbach J, Cox DR, Lathrop GM (1994) A radiation hybrid map of 506 STS markers spanning human chromosome 11. Nature Genet 6:70-76
45. Johansson B, Mertens F, Mitelman F (1993) Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci. Genes Chrom Cancer 8:205-218
46. Juliusson G, Robèrt KH, Öst A, Friberg K, Biberfeld P, Nilsson B, Zech L, Gahrton G (1985) Prognostic information from cytogenetic analysis in chronic B-lymphocytic leukemia and leukemic immunocytoma. Blood 65:134-141
47. Juliusson G, Oscier DG, Fitchett M, Ross FM, Stockdill G, Mackie MJ, Parker AC, Castoldi GL, Cuneo A, Knuutila S, Elonen E, Gahrton G (1990) Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 323:720-724
48. Juliusson G, Oscier D, Gahrton G, for the International Working Party on Chromosomes in CLL (IWCCLL) (1991) Cytogenetic findings and survival in B-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients. Leuk Lymphoma 5:21-25
49. Kalachikov S, Migliazza A, Cayanis E, Fracchiola NS, Bonaldo MF, Lawton L, Jelenc P, Ye X, Qu X, Chien M, Hauptschein R, Gaidano G, Vitolo U, Saglio G, Resegotti L, Brodjansky V, Yankovsky N, Zhang P, Soares MB, Russo J, Edlman IS, Efstratiadis A, Dalla-Favera R, Fischer SG (1997) Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics 42:369-377
50. Kobayashi H, Espinosa R III, Fernald AA, Begy C, Diaz MO, Le Beau MM, Rowley JD (1993) Analysis of deletions of the long arm of chromosome 11 in hematologic malignancies with fluorescence in situ hybridization. Genes Chrom Cancer 8:246-252
51. Lichter P, Ward DC (1990) Is non-isotopic in situ hybridization finally coming of age? Nature 345:93-95
52. Lichter P, Bentz M, Joos S (1995) Detection of chromosomal aberrations by means of molecular cytogenetics: painting of chromosomes and chromosomal subregions and comparative genomic hybridization. Methods Enzymol 254:334-359
53. Liu Y, Grandér D, Söderhäll S, Juliusson G, Gahrton G, Einhorn S (1992) Retinoblastoma gene deletions in B-cell chronic lymphocytic leukemia. Genes Chrom Cancer 4:250-256
54. Liu Y, Szekely L, Grandér D, Söderhäll S, Juliusson G, Gahrton G, Linder S, Einhorn S (1993) Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus. Proc Natl Acad Sci USA 90:8697-8701
55. Liu Y, Hermanson M, Grandér D, Merup M, Wu X, Heyman M, Rasool O, Juliusson G, Gahrton G. Detlofsson R, Nikiforova N, Buys C, Söderhäll S, Yankovsky N, Zabarovsky E, Einhorn S (1995) 13q deletions in lymphoid malignancies. Blood 86: 1911-1915
56. Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grandér D, Iyengar A, Baranova A, Kashuba V, Merup M, Wu X, Gardiner A, Mullenbach R, Poltaraus A, Hultström AL, Juliusson G, Chapman R, Tiller M, Cotter F, Gahrton G, Yankovsky N, Zabarovsky E, Einhorn S, Oscier D (1997) Cloning of two candidate tumor suppressor genes within a 10-kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. Oncogene 15:2463-2473
57. Matutes E, Oscier D, Garcia-Marco J, Ellis J, Copplestone A, Gillingham R, Hamblin T, Lens D, Swansbury GJ, Catovsky D (1996) Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients. Br J Haematol 92:382-388
58. McKeithan TW, Rowley JD, Shows TB, Diaz MO (1987) Cloning of the chromosome translocation breakpoint junction of the 1(14;19) in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 84:9257-9260
59. McKeithan TW, Ohno H, Diaz MO (1990) Identification of a transcriptional unit adjacent to the breakpoint in the 14:19 translocation of chronic lymphocytic leukemia. Genes Chrom Cancer 1:247-255
60. Merup M, Juliusson G, Wu X, Jansson M, Stellan B, Rasool O, Roijer E, Stenman G, Gahrton G, Einhorn S (1997) Amplification of multiple regions of chromosome 12, including 12q13-15, in chronic lymphocytic leukaemia. Eur J Haematol 58:174-180
61. Michaux L, Mecucci C, Stul M, Wlodarska I, Hernandez JM, Meeus P, Michaux JL, Scheiff JM, Noel H, Louwagie A, Criel A, Boogaerts M, Van Orshoven A, Cassiman JJ, Van Den Berghe H (1996) BCL3 rearrangement and t(14;19)(q32;q13) in lymphoproliferative disorders. Genes Chrom Cancer 15:38-47
62. Mitelman F, Levan G (1978) Clustering of aberrations to specific chromosomes in human neoplasms. Hereditas 89:207-232
63. Morita M, Minowada J, Sandberg AA (1981) Chromosomes and causation of human cancer and leukemia. XLV. Chromosome patterns in stimulated lymphocytes of chronic lymphocytic leukemia. Cancer Genet Cytogenet 3:293-306
64. Neilson JR, Auer R, White D, Bienz N, Waters JJ, Whittaker JA, Milligan DW, Fegan CW (1997) Deletions at 11q identify a subset of patients with typical CLL who show consistant disease progression and reduced survival. Leukemia 11:1929-1932
65. Newman RA, Peterson B, Davev FR, Brabyn C, Collins H, Brunetto VL, Duggan DB, Weiss RB, Royston I, Millard FE, Miller AA, Bloomfield CD (1993) Phenotypic markers and BCLI rearrangements in B-cell chronic lymphocytic leukemia: a cancer and leukemia group B study. Blood 82:1239-1246
66. Nowell PC, Vonderheid EC, Besa E, Hoxie JA, Moreau L, Finan JB (1986) The most common chromosome change in 86 chronic B cell or T cell tumors: a 14q32 translocation. Cancer Genet Cytogenet 19:219-227
67. Offit K, Parsa NZ, Gaidano G, Filippa DA, Louie D, Pan D, Jhanwar SC, Dalla-Favera R, Chaganti RSK (1993) 6q deletions define distinct clinico-pathologic subsets of non-Hodekin's lymphoma. Blood 82:2157-2162
68. Offit K, Louie DC, Parsa NZ, Filippa D, Gangi M, Siebert R, Chaganti RSK (1994) Clinical and morphological features of B-cell small lymphocytic lymphoma with del(6)(q21q23). Blood 83:2611-2618
69. Oscier DG, Stevens J, Hamblin TJ, Pickering RM, Lambert R, Fitchett M (1990) Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia. Br J Haematol 76:352-358
70. Panayiotidis P, Ganeshaguru K, Hoffbrand AV, Rowntree C, Jabbar SAB, Foroni L (1997) Deletion of 13q14.3 and not 13q12 is the most common genetic abnormality detected in chronic lymphocytic leukemia cells. Br J Haematol 97:844-847
71. Perez Losada A, Wessman M, Tiainen M, Hopman AHN, Willard HF, Solé F, Caballín MR, Woessner S, Knuutila S (1991) Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study. Blood 78:775-779
72. Peterson LC, Lindquist LL, Church S, Kay NE (1992) Frequent clonal abnormalities of chromosome band 13q14 in B-cell chronic lymphocytic leukemia: multiple clones, subclones, and nonclonal alterations in 82 midwestern patients. Genes Chrom Cancer 4:273-280
73. Pittman S, Catovsky D (1984) Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia Br J Haematol 58:649-660
74. Que TH, Garcia Marco J, Ellis J, Matutes E, Brito-Babapulle V, Boyle S, Catovsky D (1993) Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: analysis by stage, immunophenotype, and morphology. Blood 82:571-575
75. Raffeld M, Jaffe ES (1991) bcl-1, t(11:14), and mantle cellderived lymphomas. Blood 78:259-263
76. Raghoebier S, van Krieken JHJM, Kluin-Nelemans JC, Gillis A, van Ommen GJB, Ginsberg AM, Raffeld M, Kluin PM (1991) Oncogene rearrangements in chronic B-cell leukemia. Blood 77:1560-1564
77. Raghoebier S, Kibbelaar RE, Kleiverda K, Kluin-Nelemans JC, van Krieken JHJM, Kok F, Kluin PM (1992) Mosaicism of trisomy 12 in chronic lymphocytic leukemia detected by non-radioactive in situ hybridisation. Leukemia 6:1220-1226
78. Rechavi G, Katzir N, Brok-Simoni F, Holtzman F, Mandel M, Gurfinkel N, Givol D, Ben-Bassat I, Ramot B (1988) A search for bell. bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia. Leukemia 3:57-60
79. Robèrt KH, Möller E, Gahrton G, Eriksson H, Nilsson B (1978) B-cell activation of peripheral blood lymphocytes from patients with chronic lymphocytic leukaemia. Clin Exp Immunol 33:302-308
80. Rosenberg CL, Wong E, Petty EM, Bale AE, Tsujimoto Y, Harris NL, Arnold A (1991) PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proc Natl Acad Sci U S A 88:9638-9642
81. Ross FM, Stockdill G (1987) Clonal chromosome abnormalities in chronic lymphocytic leukemia patients revealed by TPA stimulation of whole blood cultures. Cancer Genet Cytogenet 25:109-121
82. Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik R, Patanjali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NGJ, Taylor AMR, Arlett CF, Miki T, Weissman SM, Lovett M, Collins FS, Shiloh Y (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749-1753
83. Solinas-Toldo S, Lampel S, Stilgenbauer S, Nickolenko J, Benner A, Döhner H, Cremer T, Lichter P (1997) Matrixbased comparative genomic hybridization: biochips to screen for genomic imbalances. Genes Chrom Cancer 20:399-407
84. Sparkes RS, Sparkes MC, Wilson MG, Towner JW, Benedict W, Murphree AL, Yunis JJ (1980) Regional assignment of genes for human esterase-D and retinoblastoma to chromosome band 13q14. Science 208:1042-1044
85. Stilgenbauer S, Döhner H, Bulgay-Mörschel M, Weitz S, Bentz M, Lichter P (1993) High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics. Blood 81:2118-2124
86. Stilgenbauer S, Leupolt E, Ohl S, Weiß G, Schröder M, Fischer K, Bentz M, Lichter P, Döhner H (1995) Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by FISH. Cancer Res 55:3475-3477
87. Stilgenbauer S, Bullinger L, Schröder M, Benner A, Fischer K, Bentz M, Lichter P, Döhner H (1996) Deletions of chromosome regions 6q21 and 6q27 in B-CLL detected by FISH: incidence and correlation with clinical parameters in 208 patients. Blood 88 (Suppl 1]: 238a
88. Stilgenbauer S, Liebisch P, James MR, Schröder M, Schlegelberger B, Fischer K, Bentz M, Lichter P, Döhner H (1996) Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.2-q23.1 in lymphoproliferative disorders. Proc Natl Acad Sci U S A 93:11837-11841
89. Stilgenbauer S, Schaffner C, Litterst A, Liebisch P, Gilad S, Bar-Shira A, James MR, Lichter P, Döhner H (1997) Biallelic mutations in the ATM gene in T-prolymphocytic leukemia. Nature Med 3:1155-1159
90. Stilgenbauer S, Nickolenko J, Wilhelm J, Wolf S, Weitz S, Fischer K, Boehm T, Döhner H, Lichter P (1998) Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. Oncogene 16:1891-1897
91. Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, Nowell PC, Croce CM (1984) Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 224:1403-1406
92. Ueshima Y, Bird ML, Vardiman JW, Rowley JD (1985) A 14;19 translocation in B-cell chronic lymphocytic leukemia: a new recurring chromosome aberration. Int J Cancer 36:287-290
93. Van den Berghe H, Parloir C, David G. Michaux JL, Sokal G (1979) A new characteristic karyotypic anomaly in lymphoproliferative disorders. Cancer 44:188-195
94. Vorechovsky I, Luo L, Dyer MJS, Catovsky D, Amlot PL, Yaxley JC, Foroni L, Hammarström L, Webster ADB, Yuille MAR (1997) Clustering of missense mutations in the ataxiatelangiectasia gene in a sporadic T-cell leukaemia. Nature Genet 17:96-99
95. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
96. Werner CA, Döhner H, Joos S, Trümper LH, Baudis M, Barth TF, Ott G, Möller P, Lichter P, Bentz M (1997) Highlevel DNA amplifications are common genetic aberrations in B-cell neoplasms. Am J Pathol 151:335-342
97. Wilgenbus KK, Milatovich A, Francke U, Furthmayr H (1993) Molecular cloning, cDNA sequence and chromosomal assignment of the human radixin gene and two dispersed pseudogenes. Genomics 16:199-206
98. Withers DA, Harvey RC, Faust JB, Melnyk O, Carey K, Meeker TC (1991) Characterization of a candidate bcl-1 gene. Mol Cell Biol 11:4846-4853
99. Zech L, Mellstedt H (1988) Chromosome 13 - a new marker for B-cell chronic lymphocytic leukemia. Hereditas 108:77-84