Revealing and utilizing receptor recognition mechanisms in a high-throughput world

Journal of Cellular Biochemistry

Volumn 84, Issue SUPPL. 37, 2001, Pages 126-135

  Chaiken, Irwin ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Biosensor; HIV 1; Interleukin 5; Mimetics; Phage library; Receptor

Indexed keywords

INTERLEUKIN 5; INTERLEUKIN 5 RECEPTOR; RECEPTOR; CD4 ANTIGEN; GLYCOPROTEIN GP 120; INTERLEUKIN RECEPTOR; PEPTIDE LIBRARY; VIRUS RECEPTOR;

BIOSENSOR; CONFERENCE PAPER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRUS ADSORPTION; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG DESIGN; GENETIC PROCEDURES; METABOLISM; METHODOLOGY; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIGENS, CD4; BINDING SITES; BIOSENSING TECHNIQUES; DRUG DESIGN; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; INTERLEUKIN-5; MODELS, MOLECULAR; PEPTIDE LIBRARY; RECEPTORS, HIV; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-5;

EID: 0036162614     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10079     Document Type: Conference Paper

References (35)

1. CC CKR5: A Rantes, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
2. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III
3. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
4. Refined structure of charybdotoxin: Common motifs in scorpion toxins and insect defensins
5. Structure of interleukin-5
6. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
7. Identification of a major co-receptor for primary isolates of HIV-1
8. Unwelcomed guests with master keys: How HIV uses chemokine receptors for cellular entry
9. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
10. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
11. Engineering a CD4 mimetic inhibiting the binding of the human immunodeficiency virus-1 (HIV-1) envelope glycoporotein gp 120 to human lymphocyte CD4 by the transfer of a CD4 functional site to a small natural scaffold
12. A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor α chains
13. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
14. Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation
15. The bioinformatics gold rush
16. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
17. Single chain human interleukin-5 and its asymmetric mutagenesis for mapping receptor binding sites
18. c subunits
19. Phage randomization in a charbdotoxin scaffold leads to CD4-mimetic recognition motifs that bind HIV-1 envelope through non-aromatic sequences
20. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
21. Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein
22. Mutagenesis in the carboxyl terminal region of human interleukin-5 reveals a central patch for receptor α chain recognition
23. Multisite mutagenesis of interleukin-5 differentiates sites for receptor recognition and receptor activation
24. Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients
25. Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding
26. Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding
27. Identification of receptor-binding domains on human interleukin-5 and the design of an interleukin-5-derived receptor antagonist
28. Characterization of conserved human immunodeficiency virus type 1 (HIV-1) gp120 neutralization epitopes exposed upon gp120-CD4 binding
29. Synthesis of charybdotoxin and of two N-terminal truncated analogues. Structural and functional characterization
30. Novel miniproteins engineered by the transfer of active sites to small natural scaffolds
31. Kinetic and structural analysis of CD4 mutants that are defective in HIV binding
32. Randomization of the receptor alpha chain recruitment epitope reveals a functional interleukin-5 with charge depletion in the CD loop
33. Epitope randomization redefines the functional role of glutamic acid 110 in interleukin-5 receptor activation
34. Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding
35. Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic