Phosphatidylinositol 3-kinase inhibitor failed to reduce cerebral vasospasm in dog model of experimental subarachnoid hemorrhage

Stroke

Volumn 33, Issue 2, 2002, Pages 593-599

  Kimura, Hitoshi ^a   Sasaki, Kenroh ^a   Meguro, Toshinari ^a   Zhang, John H ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

1 phosphatidylinositol 3 kinase; Dogs; Subarachnoid hemorrhage; Vasospasm, intracranial; Wortmannin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DIMETHYL SULFOXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ANGIOGRAPHY; BRAIN VASOSPASM; CONTROLLED STUDY; DOG; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBARACHNOID HEMORRHAGE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; BASILAR ARTERY; BLOTTING, WESTERN; BRAIN; CEREBRAL ANGIOGRAPHY; CHROMONES; DISEASE MODELS, ANIMAL; DOGS; ENZYME INHIBITORS; MORPHOLINES; SUBARACHNOID HEMORRHAGE; TREATMENT FAILURE; VASCULAR PATENCY; VASOSPASM, INTRACRANIAL;

EID: 0036158594     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/hs0202.103398     Document Type: Article

References (44)

1. Comparison of the use of medical resources and outcomes in the treatment of aneurysmal subarachnoid hemorrhage between Canada and the United States
2. Case-fatality rates and functional outcome after subarachnoid hemorrhage: A systematic review
3. Cerebral vasospasm
4. Stroke: Anatomy of a catastrophic event
5. Morphological changes after percutaneous transluminal angiography
6. The pathophysiology of cerebral vasospasm
7. Molecular keys to the problems of cerebral vasospasm
8. Attempts at prevention or treatment of intracranial arterial spasm: An update
9. The role of phosphoinositide 3-kinase lipid products in cell function
10. Phosphoinositide 3-kinase: A conserved family of signal transducers
11. Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: Role in mediating airway smooth muscle proliferation
12. Mechanism of endothelin-1-induced contraction in rabbit basilar artery
13. i mobilization in rat basilar smooth muscle cells
14. Mechanisms of 5-hydroxytryptamine(2A) receptor activation of the mitogen-activated protein kinase pathway in vascular smooth muscle
15. 2+]i in canine cerebral arterial smooth muscle: Participation of cellular signal pathways
16. Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: Blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidylinositol 3′-kinase
17. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
18. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
19. Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a "two-hemorrhage" canine model
20. Effects of MAPK inhibitors on cerebral vasospasm in a double-hemorrhage model in dogs
21. Acute effect of glycerol on net cerebrospinal fluid production in dogs
22. Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscle
23. Alpha 1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells: Role in mitogenesis
24. Angiotensin II induces activation of phosphatidylinositol 3-kinase in cardiomyocytes
25. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits
26. Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma
27. Oncogenes and signal transduction
28. Phosphatidylinositol-3-OH kinase as a direct target of Ras
29. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
30. Phosphoinositide kinases
31. Signaling through the lipid products of phosphoinositide-3-OH kinase
32. Role of non-catalytic subunits in G βγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ
33. Phosphatidylinositol 3-kinases signaling is important for smooth muscle cell replication after arterial injury
34. Platelet derived growth factor and subarachnoid haemorrhage: A study on cisternal cerebrospinal fluid
35. Endothelin and subarachnoid hemorrhage: An overview
36. PtdIns-3,4,5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals
37. Inhibition of agonist-induced Ca2+ entry in endothelial cell by myosin light-chain kinase inhibitor
38. Gβγ dimers stimulate vascular L-type Ca2+ channels via phosphoinositide 3-kinase
39. The activation of phosphatidylinositol 3-kinase by Ras
40. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
41. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
42. Mitogen-activated protein kinase mediates hemolysate-induced contraction in rabbit basilar artery
43. Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38 MAPK) determine a phenotype of visceral and vascular smooth muscle cells
44. Cell signaling in injured rat arteries