Biological and pathophysiological roles of endogenous methylarginines as inhibitors of nitric oxide synthase

Folia Pharmacologica Japonica

Volumn 119, Issue 1, 2002, Pages 29-35

  Masuda, Hitoshi ^a   Azuma, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; DDAH; Endogenous NOS inhibitors; Impaired NO production; System y+

Indexed keywords

ARGININE DERIVATIVE; CITRULLINE; DIMETHYLAMINE; DIMETHYLARGININASE; METHYLAMINE; N(G) METHYLARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN ARGININE METHYLTRANSFERASE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ATHEROSCLEROSIS; BIOSYNTHESIS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; ISCHEMIA; KIDNEY FAILURE; MEMBRANE TRANSPORT; MULTIPLE SCLEROSIS; PATHOGENESIS; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; REVIEW; SCHIZOPHRENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ANIMALS; ARGININE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE;

EID: 0036156578     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.119.29     Document Type: Review

References (40)

1. Gmono, di, trimethyllysine and glucosyl, galactosyl and galactosyl- δ -hydroxylysine from human urine
2. 'G-dimethylarginine from the hydrolysates of bovine brain
3. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells-inhibition involves the iron-sulfur prosthetic group and is reversible
4. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
5. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells. Involvement of S -adenosylmethionine-dependent methyltransferases
6. G-dimethylarginine dimethylaminohydrolase, from rat kidney
7. Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney
8. G-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody
9. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase
10. G-monomethyl-Larginine uptake: A mechanism for differential inhibition of synthase?
11. A caveolar complex between the cationic amino acid transporter 1 and endothelial nitricoxide synthase may explain the "arginine paradox"
12. Nitric oxide in essential and renal hypertension
13. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
14. L-Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle
15. G-methyl-L-arginine functions as an alternative substrate and mechanism-based inhibitor of nitric oxide synthase
16. An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes
17. Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitric oxide: Relevance to ischemic heart disease
18. Endothelium-dependent inhibition of platelet aggregation
19. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
20. Repeated endothelial removal augments intimal thickening and attenuates EDRF release
21. Role of endothelium in the human uterine arteries during normal menstrual cycle
22. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia
23. Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure
24. Endogenous nitric oxide synthase inhibitor: A novel marker of atherosclerosis
25. Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: Relationship to treatment method and atherosclerotic disease
26. Nitric oxide in essential and renal hypertension
27. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease
28. The arginine-nitric oxide pathway in thrombotic microangiopathy
29. Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia
30. Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans
31. Accumulation of endogenous inhibitor for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells
32. Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia
33. Endogenous asymmetrical dimethylarginine and hypertension associated with puromycin nephrosis in the rat
34. Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimetylaminohydrolase
35. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyltransferases
36. Involvement of accumulated endogenous NOS inhibitors and decreased NOS activity in the impaired neurogenic relaxation of the rabbit proximal urethra with ischemia
37. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deminases
38. Elevated endogenous nitric oxide synthase inhibitor in schizophrenic plasma may reflect abnormalities in brain nitric oxide production
39. G-dimethylarginines in multiple sclerosis patients: Preliminary observations
40. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase