Involvement of accumulated endogenous NOS inhibitors and decreased NOS activity in the impaired neurogenic relaxation of the rabbit proximal urethra with ischaemia

British Journal of Pharmacology

Volumn 133, Issue 1, 2001, Pages 97-106

  Masuda, Hitoshi ^a   Tsujii, Toshihiko ^a   Okuno, Tetsuo ^a   Kihara, Kazunori ^a   Goto, Moritaka ^a   Azuma, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

ADMA; Ischaemia; L arginine; L NMA; NOS activity; Proximal urethra

Indexed keywords

ARGININE; CALCIUM ION; CYCLIC GMP; N(G) METHYLARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; SYMMETRIC N(G),N'(G) DIMETHYLARGININE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG INHIBITION; ELECTROSTIMULATION; ENZYME ACTIVITY; ILIAC ARTERY OBSTRUCTION; KIDNEY ISCHEMIA; MALE; MICTURITION DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; URETHRA DISEASE;

EID: 0034987458     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704050     Document Type: Article

References (39)

1. Electrically-induced nerve-mediated relaxation of rabbit urethra involves nitric oxide
2. Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction
3. Accumulation of endogenous inhibitor for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells
4. A possible role of endogenous inhibitor for nitric oxide synthesis in the bovine ciliary muscle
5. Neural control of urethral outlet activity in vivo: Role of nitric oxide
6. Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension
7. Characteristics of neural injury after abdomino-perineal resection
8. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia: A randomized, controlled study
9. L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy volunteers
10. Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits
11. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease
12. G-monomethyI-L-arginine uptake: A mechanism for differential inhibition of synthase?
13. Signal transduction by guanylyl cyclase
14. L-arginine restores endothelium-dependent relaxation in pulmonary circulation of chronically hypoxic rats
15. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase
16. Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs
17. Nitric oxide synthase isozymes: Characterization, purification, molecular cloning, and functions
18. Characterization of nitric oxide synthase activity in sheep urinary tract: Functional implications
19. Biosynthesis and metabolism of endothelium-derived nitric oxide
20. A novel signal transduction mechanism for transcellular communication
21. L-arginine infusion induces hypotension and diuresis/natriuresis with concomitant increased urinary excretion of nitrite/nitrate and cyclic GMP in humans
22. G-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody
23. Kinetic characteristics of nitric oxide synthase from rat brain
24. Nitroarginine inhibits endothelium-derived relaxation
25. Chronic ischemia alters prostate structure and reactivity in the rabbit
26. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
27. Bladder and erectile dysfunction before and after rectal surgery for cancer
28. Functional effect on chronic ischemia on the rabbit urinary bladder
29. Endothelium-derived relaxing and contracting factors: Perspective in nephrology
30. Metabolism of methylarginines by human vasculature: Implications for the regulation of nitric oxide synthesis
31. Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia
32. Nitric oxide-induced relaxation during the contraction with endothelin-1 is mediated through elevation of cyclic GMP
33. A caveolar complex between the cationic amino acid transporter I and endothelial nitric-oxide synthase may explain the "arginine paradox"
34. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: Antinociceptive and cardiovascular effects
35. C-GMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase
36. An anatomical explanation for bladder dysfunction following rectal and uterine surgery
37. Purification of a soluble isoform of guanylyl cyclase-activating factor synthase
38. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis
39. Vesicourethral dysfunction following pelvic visceral ablative surgery