Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells transfected with the Ha-ras oncogene

Mutagenesis

Volumn 17, Issue 1, 2002, Pages 67-72

  Peitl, Paulo ^a   Mello, Stephano S ^a   Camparoto, Marjori L ^a   Passos, Geraldo A S ^a   Hande, Manoor P ^b   Cardoso, Renato S ^a   Sakamoto Hojo, Elza T ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL IMMORTALIZATION; CELL STRAIN 3T3; CENTROMERE; CHROMATID; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA SEQUENCE; FLUORESCENCE IN SITU HYBRIDIZATION; FREQUENCY ANALYSIS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; RNA CAPPING; TELOMERE;

ANIMALIA; ROBERTSONIA;

EID: 0036153371     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/17.1.67     Document Type: Article

References (54)

1. Neoplastic transformation of 3T3 mouse embryo cells with c-myc and c-Ha-ras-1 oncogenes
2. A critical role for telomeres in suppressing and facilitating carcinogenesis
3. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
4. Analysis of restriction enzyme-induced chromosome aberrations in the interstitial telomeric repeat sequences of CHO and CHE cells by FISH
5. Imunofluorescent analysis of the organization of telomeric DNA sequences and their involvement in chromosomal aberrations in hamster cells
6. Structure and function of telomeres
7. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
8. Classification of X-rays-induced Robertsonian fusion-like configurations in mouse splenocytes
9. Ras oncogene in human cancer: A review
10. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
11. Molecular cytogenetic evidence to characterise breakpoint regions in Robertsonian translocations
12. Essential role for oncogenic Ras in tumour maintenance
13. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
14. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
15. Unlimited mileage from telomerase?
16. For better or worse? Telomerase inhibition and cancer
17. The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle
18. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
19. Effects of DNA nonhomologous end-joining factors on telomere length and chromosome stability in mammalian cells
20. Healing of broken human chromosome by the addition of telomeric repeats
21. Robertsonian metacentrics of the house mouse lose telomeric sequences but retain some minor satellite DNA in the pericentromeric area
22. Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts
23. Telomere length regulation
24. Creation of human tumour cells with defined genetic elements
25. Induction of telomerase activity by in vivo X-irradiation of mouse splenocytes and its possible role in chromosome healing
26. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
27. Elongated telomeres in SCID mice
28. -/- mice and patients with ataxia-telangiectasia
29. Telomeres shorten during ageing of human fibroblasts
30. Telomerase primer specificity and chromosome healing
31. Telomere reduction in colo-rectal carcinoma and with ageing
32. Evidence for a telomere-independent 'clock' limiting ras oncogene-driven proliferation of human thyroid epithelial cells
33. Induction of telomerase activity and chromosome aberrations in human tumour cell lines following X-irradiation
34. Hypervariable ultra-long telomeres in mice
35. Specific association of human telomerase activity with immortal cells and cancer
36. Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during differentiation of leukemic cells
37. Ha-Ras-1 oncogene dosage differentially affects Balb/3T3 cells growth factor requirement and tumorigenicity
38. Interstitial localisation of telomeric DNA sequences in the Indian muntjac chromosomes: Further evidence for tandem chromosome fusions in the karyotypic evolution of the Asian muntjacs
39. Distribution of non telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes
40. Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break
41. Loss of telomeric sites in the chromosomes of Mus musculus domesticus (Rodentia: Muridae) during Robertsonian rearrangements
42. Cytological and molecular characterisation of centromeres in Mus domesticus and Mus spretus
43. Telomere maintenance in telomerase-deficient mouse embryonic stem cells: Characterization of an amplified telomeric DNA
44. Telomeric structure in cells with chromosome end association
45. Telomeric signals in Robertsonian fusion and fission chromosomes: Implications for the origin of pseudoaneuploidy
46. A survey of telomerase activity in human cancer
47. Chromosome healing, telomere capture and mechanisms of radiation-induced chromosome breakage
48. Telomere length, chromatin structure and chromosome fusigenic potential
49. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis
50. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
51. Rebuilding the road to cancer
52. Telomeres: Beginning to understand the end
53. Telomeres in the mouse have large interchromosomal variations in the number of T2AG3 repeats