The discovery of PD 89211 and related compounds: Selective dopamine D4 receptor antagonists

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 26, Issue 2, 2002, Pages 219-226

  Pugsley, Thomas A ^a   Shih, Yu Hsin ^a   Whetzel, Steven Z ^a   Zoski, Kim ^a   Van Leeuwen, Don ^a   Akunne, Hyacinth ^a   Mackenzie, R ^a   Heffner, Thomas G ^a   Wustrow, David ^a   Wise, Lawrence D ^a  

^a PFIZER INC   (United States)

Author keywords

3H Spiperone binding; Catecholamine turnover; Dopamine D4 receptor; Rat brain; Schizophrenia; Thymidine uptake

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; 3 HYDROXYBENZYLHYDRAZINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ADRENERGIC RECEPTOR; BENZENEMETHANOL; CATECHOLAMINE; CLOZAPINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; FUNCTIONAL GROUP; HALOPERIDOL; KETANSERIN; NORADRENALIN; PD 89211; PRAZOSIN; QUINPIROLE; RACLOPRIDE; RECEPTOR SUBTYPE; SEROTONIN RECEPTOR; SPIPERONE; THYMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CATECHOLAMINE SYNTHESIS; CHO CELL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE METABOLISM; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG UPTAKE; HIPPOCAMPUS; MALE; MITOGENESIS; MOUSE; NONHUMAN; RAT; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZIMIDAZOLES; BENZYL ALCOHOL; CATECHOLAMINES; CHO CELLS; CRICETINAE; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, KNOCKOUT; PIPERAZINES; RATS; RATS, LONG-EVANS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 0036138828     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(01)00252-4     Document Type: Article

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