Rat costochondral chondrocytes produce 17β-estradiol and regulate its production by 1α,25(OH)2D3

Bone

Volumn 30, Issue 1, 2002, Pages 57-63

  Sylvia, V L ^a   Gay, I ^a   Hardin, R ^a   Dean, D D ^a   Boyan, B D ^a   Schwartz, Z ^a,b,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

1 ,25(OH)2D3; 24R,25(OH)2D3; Aromatase; Chondrocyte cultures; CYP19; Estradiol; Transforming growth factor 1 (TGF 1)

Indexed keywords

AROMATASE; COLECALCIFEROL; ESTRADIOL; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; ESTROGEN SYNTHESIS; FEMALE; GENE EXPRESSION REGULATION; GROWTH PLATE; MALE; NONHUMAN; RAT; SEX DIFFERENCE;

24,25-DIHYDROXYVITAMIN D 3; ANIMALS; AROMATASE; CALCITRIOL; CELLS, CULTURED; CHONDROCYTES; ESTRADIOL; FEMALE; GROWTH PLATE; MALE; RATS; RNA, MESSENGER; SEX CHARACTERISTICS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036138693     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00630-5     Document Type: Article

References (41)

1. Age-dependent responsiveness of rabbit and human cartilage cells to sex steroids in vitro
2. 3
3. 3 via alternate pathways dependent on chondrocyte maturation state
4. The biology, chemistry, and biochemistry of the mammalian growth plate
5. Differential expression of phenotype by resting zone and growth region costochondral chondrocytes in vitro
6. 2
7. 3 regulates cartilage and bone via autocrine and endocrine mechanisms
8. 3 signaling in chick enterocytes: Enhancement of tyrosine phosphorylation and rapid stimulation of mitogen-activated protein (MAP) kinase
9. 17-β estradiol acts directly on the clonal osteoblastic cell line UMR 106
10. Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth
11. Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: Adenosine 3′,5′-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5′ genomic DNA
12. Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450
13. 1,25-Dihydroxycholecalciferol stimulates conversion of androstenedione into oestrone by human skin fibroblasts in culture
14. Aromatase cytochrome P450 transcripts are detected in fractured human bone but not in normal skeletal tissue
15. Assay of aromatase activity
16. Estrogen receptors in fracture healing
17. Sex-dependent effects of 17-β-estradiol on chondrocyte differentiation in culture
18. Evidence for receptors specific for 17β-estradiol and testosterone in chondrocyte cultures
19. 3 which mediates rapid activation of protein kinase C
20. Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women
21. Bone has a sexually dimorphic response to aromatase deficiency
22. 3 1α- and 24-hydroxylase activity in cultured growth plate chondrocytes in a maturation-dependent manner
23. Specific beta estradiol binding in cartilage and serum from young mice and rats is age dependent
24. Estrogen synthesis by osteoblast cell lines
25. Aromatase in human bone tissue
26. 3 by growth zone and resting zone chondrocytes is dependent on cell maturation and is regulated by hormones and growth factors
27. 3 metabolites
28. Effect of 17β-estradiol on chondrocyte membrane fluidity and phospholipid metabolism is membrane-specific, sex-specific, and cell maturation-dependent
29. Effects of vitamin D metabolites on collagen production and cell proliferation of growth zone and resting zone cartilage cells in vitro
30. Aromatase expression of human osteoblast-like cells
31. Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6
32. TGF-β1 stimulates expression of the aromatase (CYP19) gene in human osteoblast-like cells and THP-1 cells
33. Oestrogen receptor deficiency; Consequences for growth
34. Measurement of protein using bicinchoninic acid
35. Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells
36. The membrane effects of 17β-estradiol on chondrocyte phenotypic expression are mediated by activation of protein kinase C through phospholipase C and G-proteins
37. 17β-Estradiol regulation of protein kinase C activity in chondrocytes is sex-dependent and involves nongenomic mechanisms
38. 3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts
39. Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary
40. Novel aromatase transcripts from bovine placenta contain repeated sequence motifs
41. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro