24,25-(OH)2D3 regulates cartilage and bone via autocrine and endocrine mechanisms

Steroids

Volumn 66, Issue 3-5, 2001, Pages 363-374

  Boyan, Barbara D ^a   Sylvia, Victor L ^a   Dean, David D ^a   Schwartz, Zvi ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

1 ,25(OH)2D3; 24(R),25(OH)2D3; Chondrocytes; Growth plate; Rapid actions; Vitamin D; Vitamin D receptors

Indexed keywords

24,25 DIHYDROXYCOLECALCIFEROL; ARACHIDONIC ACID; CALCITRIOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 1; DIACYLGLYCEROL; ISOENZYME; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE D; PHOSPHOLIPASE D2; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; PROSTANOID EP1 RECEPTOR; PROSTANOID EP2 RECEPTOR; PROSTANOID RECEPTOR; PROTEIN KINASE C; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; AUTOCRINE EFFECT; BONE; CALCIUM TRANSPORT; CARTILAGE; CARTILAGE CELL; CELL MATURATION; CELL MEMBRANE; CONFERENCE PAPER; CYTOLOGY; DOWN REGULATION; DRUG MECHANISM; ENCHONDRAL OSSIFICATION; ENDOCRINE FUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; GENE EXPRESSION; GROWTH PLATE; MEMBRANE BINDING; METABOLITE; METHODOLOGY; NONHUMAN; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEREOSPECIFICITY; TARGET CELL;

24,25-DIHYDROXYVITAMIN D 3; ANIMALS; AUTOCRINE COMMUNICATION; BONE AND BONES; CARTILAGE; CHONDROCYTES; ENDOCRINE SYSTEM; HUMANS;

EID: 0035342674     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00162-8     Document Type: Conference Paper

References (92)

1. Isolation and identification of 24,25dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney
2. 3 1- and 24-hydroxylases; their in vivo regulation
3. 3
4. 3. Effect of blocking of 24-hydroxylation on the functions of vitamin D
5. Vitamin D; two dihydroxylated metabolites are required for normal chicken egg hatchability
6. 3 on bone γ-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats
7. Healing of rachitic lesions in chicks by 24R,25-dihydroxycholecalciferol administered locally into bone
8. The influence of vitamin D metabolites on collagen synthesis by chick cartilage in organ culture
9. Comparison of the effects of vitamin D metabolites on collagen synthesis and resorption of fetal rat bone in organ culture
10. 3
11. Proteolipid-lipid relationships in normal and vitamin D-deficient chick cartilage
12. The effect of vitamin D deficiency on rat bone lipid composition
13. Lipid composition of isolated epiphyseal cartilage cells, membranes and matrix vesicles
14. 3 in epiphyseal cartilage
15. 3 metabolite biologically active in cartilage
16. 3 receptors in rat epiphyseal cartilage
17. Effects of vitamin D metabolites on healing of low phosphate, vitamin D-deficient induced rickets in rats
18. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone
19. Mineral-matrix interactions in bone and cartilage
20. Molecular biology of matrix vesicles
21. Bone and cartilage differentiation
22. Mineralization of normal and rachitic chick growth cartilage; vascular canals, cartilage calcification and osteogenesis
23. Possible role of extracellular matrix vesicles in initial calcification of healing rachitic cartilage
24. Changes in the distribution of extracellular matrix vesicles during healing of rat tibial bone (computerized morphometry and electron microscopy)
25. Matrix vesicles are enriched in metalloproteinases that degrade proteoglycans
26. Chondrocyte cultures express matrix metalloproteinase mRNA and immunoreactive protein; Stromelysin-1 and 72 kDa gelatinase are localized in extracellular matrix vesicles
27. Partition of inorganic ions and phospholipids in isolated cell, membrane and matrix vesicle fractions; Evidence for Ca-Pi-acidic phospholipid complexes
28. Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes
29. Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage
30. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
31. Effects of serum calcium and phosphorous on skeletal mineralization in vitamin D-deficient rats
32. Further characterization of a nucleational agent in hypertrophic cell extracellular cartilage fluid
33. Partition of calcium, phosphate and protein in the fluid phase aspirated at calcifying sites in epiphyseal cartilage
34. Alterations in the lipids of bone caused by hypervitaminosis A & D
35. Biology, chemistry and biochemistry of the mammalian growth plate
36. 3
37. Histochemistry and biochemistry of calcification with special reference to the role of lipids
38. Effect of vitamin D metabolites on the expression of alkaline phosphatase activity by epiphyseal hypertrophic chondrocytes in primary cell culture
39. 3 in growth plate cartilage of rats
40. Addition of human recombinant BMP-2 to inactive commercial human DFDBA makes it an effective composite bone inductive implant material
41. A synopsis of craniofacial growth
42. Developmental changes in responsiveness to vitamin D metabolites
43. 3 is a metabolite of vitamin D essential for bone formation
44. In vitro studies on the regulation of endochondral ossification by vitamin D
45. Differential expression of phenotype by resting zone and growth region costochondral chondrocytes in vitro
46. 3
47. 2 specific activities
48. 2 activity of growth zone and resting zone cartilage cells in vitro
49. Effects of vitamin D metabolites on collagen production and cell proliferation of growth zone and resting zone cartilage cells in vitro
50. 3-responsive alkaline phosphatase in cultured chondrocytes
51. 3-responsive phenotype characteristic of growth zone chondrocytes
52. The effects of vitamin D metabolites on the plasma and matrix vesicle membranes of growth and resting cartilage cells in vitro
53. Alterations in phospholipid-dependent (Na++K+) -ATPase activity due to lipid fluidity. Effects of cholesterol and Mg2+
54. Difference in microviscosity induced by different cholesterol levels in the surface membrane lipid layer of normal lymphocytes and malignant lymphoma cells
55. 3 is dependent on cell maturation
56. 3
57. 3 homologs
58. 3; design, synthesis, and preliminary biological evaluation
59. 3 which mediates rapid activation of protein kinase C
60. 3 in mediating intestinal calcium transport; The use of analogs to study membrane receptors for vitamin D metabolites and to determine receptor ligand conformational preferences
61. 3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor; A status report
62. 3; Evidence for a nonnuclear membrane receptor in the chick tibial fracture-healing callus
63. 3 rapidly decrease the in vitro intestinal calcium uptake in the Atlantic cod, Gadus morhua
64. 3 metabolites in chondrocyte cultures
65. 2 and cyclooxygenase-1 (Cox-1) but not Cox-2 in growth plate chondrocytes
66. 3
67. 2 production by vitamin D metabolites in growth zone and resting zone chondrocyte cultures is dependent on cell maturation
68. 2
69. 3 in growth zone and resting zone chondrocyte cultures
70. Inositol lipids and cell proliferation
71. 3 via protein kinase C and indirectly through prostaglandin production in resting zone chondrocytes
72. Fatty acid activation of peroxisome proliferator-activated receptor (PPAR)
73. 3 on growth plate chondrocytes in a metabolite-specific and cell maturation-dependent manner
74. 2 on costochondral chondrocyte differentiation is mediated by cAMP and protein kinase C
75. 3-mediated effects on resting zone chondrocytes
76. 3-dependent effects on PKC via the EP1 receptor (abstract #1264)
77. Cyclooxygenases 1 and 2
78. Prostaglandin endoperoxide synthases-1 and -2
79. Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets
80. Inhibition of phospholipase C-dependent processes by U73,122
81. 2 and phospholipase C in growth zone chondrocytes
82. Cell signalling through phospholipid breakdown
83. 3-dependent stimulation of alkaline phosphatase activity by A23187 suggests a role for calcium in the mechanism of vitamin D regulation of chondrocyte cultures
84. Vitamin D metabolites regulate matrix vesicle metalloproteinase content in a cell maturation-dependent manner
85. Abnormal bone development in mice deficient for the vitamin D 24-hydroxylase gene
86. Targeted inactivation of vitamin D hydroxylases in mice
87. 3 by growth zone and resting zone chondrocytes is dependent on cell maturation and is regulated by hormones and growth factors
88. 3 1α- and 24-hydroxylase activity in cultured growth plate chondrocytes in a maturation-dependent manner
89. 3 regulation of matrix vesicle protein kinase C occurs both during biosynthesis and in the extracellular matrix
90. Protein kinase C. Structure, function and regulation
91. 14C]-acetate into the organic acids of bone