Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin

Pediatric Research

Volumn 51, Issue 1, 2002, Pages 112-118

  Rodrigues, C M P ^a   Sola S ^a   Silva, R F M ^a   Brites, D ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; CYTOCHROME C;

AGED; AGING; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BILIRUBIN METABOLISM; BRAIN PROTECTION; CELL MATURATION; CELL ORGANELLE; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DISEASE PREDISPOSITION; DRUG ACCUMULATION; ENZYME REGULATION; FETUS; GLIA CELL; KERNICTERUS; MEMBRANE PERMEABILITY; MITOCHONDRION SWELLING; NERVE CELL; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

EID: 0036134456     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200201000-00020     Document Type: Article

References (40)

1. Bilirubin encephalopathy: Effect on RNA polymerase activity and chromatin template activity in the brain of Gunn rat
2. Impairment of DNA synthesis in Gunn rat cerebellum
3. Bilirubin toxicity in neuronal cell lines N-115 and NBR-10A
4. Kernicterus: Effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of Gunn rat
5. Bilirubin decreases phosphorylation of synapsin I, a synaptic vesicle-associated neuronal phosphoprotein, in intact synaptosomes from rat cerebral cortex
6. Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: Role of concentration and pH
7. Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo
8. Mode of inhibitory action of bifirubin on protein kinase C
9. Bilirubin and amyloid-β peptide induce cytochrome c release through mitochondrial membrane permeabilization
10. Bilirubin-induced apoptosis in glial and nerve cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid
11. Mitochondrial control of apoptosis
12. Mitochondria and apoptosis
13. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
14. A novel role of ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
15. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
16. Molecular characterization of mitochondrial apoptosis-inducing factor
17. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
18. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
19. The proto-oncogene Bcl-2 and its role in regulating apoptosis
20. Cholestasis confers resistance to the rat liver mitochondrial permeability transition
21. Triiodothyronine is a high-affinity inhibitor of amino acid transport system L1 in cultured astrocytes
22. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination
23. The ready isomerization of bilirubin IX- in aqueous solution
24. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1
25. The role of the matrix calcium level in the enhancement of mitochondrial pyruvate carboxylation by glucagon pretreatment
26. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
27. Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency
28. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
29. The neurotoxicity of bilirubin
30. Bilirubin induces apoptosis via activation of NMDA receptors in developing rat brain neurons
31. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
32. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
33. Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
34. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
35. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
36. 2+ ions
37. Bax directly induces release of cytochrome c from isolated mitochondria
38. Age-dependent sensitivity of cultured rat glial cells to bilirubin toxicity
39. Oxidation of bilirubin by brain mitochondrial membranes - Dependence on cell type and postnatal age
40. Bilirubin toxicity and differentiation of cultured astrocytes