Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans: A murine transgenic model

Journal of Clinical Investigation

Volumn 97, Issue 8, 1996, Pages 1818-1826

  Gyetko, Margaret R ^a,b   Chen, Gwo Hsiao ^a   McDonald, Roderick A ^a   Goodman, Richard ^a   Huffnagle, Gary B ^a   Wilkinson, Camille C ^a   Fuller, Jennifer A ^a   Toews, Galen B ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cellular recruitment; Fungal pathogens; Lung inflammation; Plasminogen activators; Transgenic mice

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLONY FORMING UNIT; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; ENZYME ACTIVITY; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INFLAMMATION; LUNG MYCOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, DIFFERENTIATION; BRAIN; CD8-POSITIVE T-LYMPHOCYTES; COLONY-FORMING UNITS ASSAY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; FEMALE; INFLAMMATION; LUNG DISEASES, FUNGAL; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, TRANSGENIC; SPLEEN; URINARY PLASMINOGEN ACTIVATOR;

EID: 0029935421     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118611     Document Type: Article

References (47)

1. Saksela, O . and D.B. Rifkin. 1988. Cell-associated plasminogen activation: regulation and physiological functions. Annu. Rev. Cell Biol. 4:93-126.
2. Vassalli, J.. A. Sappino, and D. Belin 1991. The plasminogen activator/ plasmin system J. Clin. Invest 88.1067-1072.
3. Chapman, H.A., J.J. Reilly, and L Kobzik 1988 Role of plasminogen activator in degradation of extracellular matrix proteins by live human alveolar macrophages. Am. Rev. Respir. Dis. 137:412-419.
4. Kirchheimer, J.C., and H.G. Remold. 1989. Endogenous receptor-bound urokinase mediates tissue invasion of human monocytes. J. Immunol 143:2634-2639.
5. Estreicher, A., J. Muhlhause, J. Carpentier, L. Orci, and J. Vassalli. 1990. The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J. Cell Biol. 111:783-792.
6. Danø, K., P.A. Andreasen, J. Grondahl-Hansen, P. Kristensen, L.S. Nielsen, and L. Skriver. 1985. Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res. 44:139-265.
7. Nykjaer, A., C. Petersen, E. Christensen, O. Davidsen, and J. Gliemann. 1990. Urokinase receptors in human monocytes Biochim Biophys. Acta. 1052: 399-407.
8. Plesner, T., M. Ploug, V. Ellis, E. Ronne. G, Høyer-Hansen, M. Wittrup, T.L. Pedersen, T. Tscherning, K. Danø, and N.E. Hansen. 1994. The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracelllular compartments to the plasma membrane on stimulation of human neutrophils. Blood. 83:808-815.
9. Gyetko, M.R , R.F. Todd III, C.C. Wilkinson, and R.G. Sitrin. 1994. The urokinase receptor is required for human monocyte chemotaxis in vitro. J. Clin. Invest. 93:1380-1387.
10. Gyetko, M.R., R.G. Sitrin, J.A. Fuller, R.F. Todd III, H. Petty, and T.J. Standiford. 1995. Function of the urokinase receptor (CD87) in neutrophil chemotaxis. J. Leukocyte Biol. 58:533-538.
11. Ossowski, L. 1988. Plasminogen activator dependent pathways in the dissemination of human tumor cells in the chick embryo. Cell. 52:312-328.
12. Ossowski, L., H. Russo-Payne, and E.L. Wilson 1991 Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse. Cancer Res. 51:274-281.
13. Mignatti, P., E. Robbins, and D.B. Rifkin. 1986. Tumor invasion through the human amniotic membrane requirement for a proteinase cascade. Cell. 47:487-498.
14. Carmeliet, P., L. Schoonjans, L. Kieckens, B. Ream, J. Degen, R Bronson, R. De Vos, J.J. van den Oord, D. Collen, and R.C. Mulligan. 1994. Physio-logical consequences of loss of plasminogen activator gene function in mice. Nature (Lond.). 368:419-424.
15. Zini, J.M., S.C. Murray, C.H Graham, P.K. Lala, K. Kariko, E S. Barnathan, A Mazar, J. Henkin, D.B. Cines, and K.R. McCrae. 1992. Characterization of urokinase receptor expression by human placental trophoblasts. Blood 79 2917-2929.
16. Hofmann, O.E., I. Glatstein, F. Schatz, D. Heller, and L. Deligdisch. 1994. Immunohistochemical localization of urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in early human implantation sites. Am. J. Obstet. Gynecol. 170:671-676.
17. Chuck, S.L., and M.A. Sande. 1989. Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl. J. Med 321:794-799.
18. + T cells. J Exp Med. 173:793-800.
19. Huffnagle, G. B., J. L. Yates, and M. F. Lipscomb. 1991. T cell-mediated immunity in the lung: a Cryptococcus neoformans pulmonary infection model using SCID and athymic nude mice. Infect. Immun. 59:1423-1433.
20. Miller, S.A., D.D. Dykes, and H F. Polesky. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
21. Degen, S J.F., J.L. Heckel, E. Reich, and J.L. Degen. 1987. The murine urokinase-type plasminogen activator gene. Biochemistry. 26:8270-8279.
22. Turka, L.A., R.E. Goodman, J.L. Rutkowski, A.A.F. Sima, A. Merry, R.S. Mitra, T. Wrone-Smith, G.B. Toews, R.M. Strieter, and B.J. Nickoloff. 1995. IL-12. a potential link between nerve cells and the immune system. Mol. Med 1:690-699.
23. Wilson, D., J. Bennett, and J. Bailey. 1968. Serologic groupings of Cryptococcus neoformans Proc Soc. Exp. Med. Biol. 127:8204323.
24. Curtis, J.L., G.B. Huffnagle, G.-H. Chen, M.L Warnock, M.R. Gyetko, R.A. McDonald, P.J. Scott, and G.B. Toews. 1994. Experimental murine pulmonary cryptococcosis: differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of Cryptococcus neoformans J. Lab. Invest. 71:113-126.
25. Lavnikova, N., S. Prokhorova, L. Helyar, and D.L. Laskin. 1993. Isolation and partial characterization of subpopulations of alveolar macrophages, granulocytes, and highly enriched interstitial macrophages from rat lung. Am. J Respir. Cell Mol Biol. 8:384-392.
26. Mody, C.H., G.B. Toews, and M.F. Lipscomb. 1989. Treatment of murine cryptococcosis with cyclosporin-A in normal and athymic mice. Am. Rev. Respir. Dis. 139:8-13.
27. Zar, J.H. 1984. Biostatistical Analysis. Prentice-Hall. Englewood Cliffs, NJ. 121-129.
28. Vecchiarelli, A., D. Pietrella, M. Dottorini, C. Monari, C. Retini, T Todisco, and F. Bistoni. 1994. Encapsulation of Cryptococcus neoformans regulates fungicidal activity and the antigen presentation process in human alveolar macrophages. Clin. Exp Immunol. 98:217-223.
29. Vecchiarelli, A., M. Dottorini, D. Ptetrella, C. Monari, C. Retini, T. Todisco, and F. Bistoni. 1994. Role of human alveolar macrophages as antigen-presenting cells in Cryptococcus neoformans infection. Am. J. Respir. Cell Mol. Biol. 11.130-137.
30. Chen, G.-H., J.L. Curtis, C.H. Mody, P.J. Christensen, L.R. Armstrong, and G.B. Toews. 1994. Effect of granulocyte-macrophage colony-stimulating factor on rat alveolar macrophage anticryptococcal activity in vitro. J. Immunol 152:724-734.
31. Collins, H.L., and G.J. Bancroft. 1992. Cytokine enhancement of complement-dependent phagocytosis by macrophages: synergy of tumor necrosis factor-α and granulocyte-macrophage colony-stimulating factor for phagocytosis of Cryptococcus neoformans. Eur J. Immunol. 22:1447-1454.
32. +) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans J. Immunol. 144:1472-1477.
33. Nykjacr, A., B. Møller, R.F. Todd III, T. Christensen, P.A. Andreasen, J. Gliemann, and C.M. Petersen 1994. Urokinase receptor: an activation antigen in human T lymphocytes. J. Immunol. 152:505-516.
34. Baker, M.S., P. Bleakley, G.C. Woodrow, and W.F. Doe. 1990. Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects of extracellular matrix degradation. Cancer Res. 50 4676-4684.
35. Quax, P.H.A, G.N.P. van Muijen, E.J.D. Weening-Verhoeff, LR Lund, K. Danø, D.J. Ruiter, and J.H. Verheijen. 1991. Metastatic behavior of human melanoma cell lines in nude mice correlates with the urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase mediated matrix degradation. J. Cell Biol. 115:191-199.
36. Tsuboi, R., and D. Rifkin. 1990. Bimodal relationship between invasion of the amniotic membrane and plasminogen activator activity. Int. J. Cancer. 46 56-60.
37. Murphy, G., and A. Doherty. 1992. The matrix metalloproteinases and their regulation. Am. J. Respir. Cell Mol. Biol. 7:120-125.
38. Senior, R., and S Shapiro. 1992. Introduction: the matrix metalloproteinase family. Am. J. Respir. Cell Mol. Biol. 7:119-127.
39. Welgus, H G., N.L. Connolly, and R.M. Senior. 1986 12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. J. Clin. Invest. 77:1675-1681.
40. Miller, M.D., and M.S. Krangel. 1992. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit. Rev. Immunol. 12:17-46.
41. Sitrin, R.G., S.B. Shollenberger, R.M. Stricter, and M.R. Gyetko. 1996. Endogenously produced urokinase activity amplifies tumor necrosis factor-α secretion by THP-1 mononuclear phagocytes. J. Leukocyte Biol. 59:302-311.
42. Matsushima, K., M Taguchi, E.J. Kovacs, H A. Young, and J J. Oppenheim. 1986. Intracellular localization of human monocyte associated interleukin-1 (IL-I) activity and release of biologically active IL-1 from monocytes by trypsin and plasmin. J. Immunol. 136:2883-2891.
43. Auberger, P., S. Sonthonnax, J.-F. Peyron, B. Mari, and M. Fehlmann 1990 A chymotryptic-type serine protease is required for IL-2 production by Jurkat T cells. Immunology. 70:547-550.
44. Kaufmann, S.H E. 1993. Fundamental Immunology. Raven Press, Ltd . New York. 1251-1286.
45. Reich, J.M., and R.E. Johnson. 1991. Mycobacterium avium complex pulmonary disease. Am. Rev. Respir. Dis. 143:1381-1385.
46. Negri, M , I. Sheiban, P. Arigliano, S. Tonni, G. Montresor, S. Carlini, and F. Manzato 1993. Interrelation between angiographie seventy of coronary artery disease and plasma levels of insulin. C-peptide and plasminogen activator inhibitor-1. Am. J. Cardiol. 72:397-401.
47. Frist, S., H. Taylor, K. Kirk, J. Grammer, X. Li, H. Grenett, and F. Booyse. 1995 Expression of PAI-1, t-PA and u-PA in cultured human umbilical vein endothelial cells derived from racial groups. Thromb Res 77:279-290