Endogenously produced urokinase amplifies tumor necrosis factor-α secretion by THP-1 mononuclear phagocytes

Journal of Leukocyte Biology

Volumn 59, Issue 2, 1996, Pages 302-311

  Sitrin, Robert G ^a,b   Shoilenberger, Susan B ^a   Strieter, Robert M ^a   Gyetko, Margaret R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cytokine; Lipopolysaccharide; Macrophage; Plasminogen activator

Indexed keywords

APROTININ; LIPOPOLYSACCHARIDE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TUMOR NECROSIS FACTOR ALPHA; UROKINASE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MACROPHAGE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; HUMANS; LEUKEMIA, MONOCYTIC, CHRONIC; LIPOPOLYSACCHARIDES; MICE; PHAGOCYTES; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATORS; STIMULATION, CHEMICAL; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; URINARY PLASMINOGEN ACTIVATOR;

EID: 0029871028     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.59.2.302     Document Type: Article

References (55)

1. Gyetko, M., Shollenberger, S., Sitrin, R. (1992) Urokinase expression in mononuclear phagocytes: cytokine-specific modulation by interferon-γ and tumor necrosis factor-α. J. Leukoc. Biol. 51, 256-263.
2. Vassalli, J.-D., Wohlwend, A., Belin, D. (1992) Urokinase-catalyzed plasminogen activation at the monocyte/macrophage cell surface: a localized and regulated proteolytic system. Curr. Top. Microbiol. Immunol. 181, 65-86.
3. Collart, M.A., Belin, D., Vassalli, J., DeKossodo, S., Vassalli, P. (1986) γ Interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin-1, and urokinase genes, which are controlled by short-lived repressors. J. Exp. Med. 164, 2113-2118.
4. Lu, H., Mirshahi, M., Krief, P., Soria, C., Soria, J., Mishal, Z., Bertrand, O., Perrot, J., Li, H., Picot, C., Pujade, E., Bernadou, A., Caen, J. (1988) Parallel induction of fibrinolysis and receptors for plasminogen and urokinase by interferon gamma on U937 cells. Biochem. Biophys. Res. Commun. 155, 418-422.
5. Kirchheimer, J.C., Remold, H.G. (1989) Endogenous receptor-bound urokinase mediates tissue invasion of human monocytes. J. Immunol. 143, 2634-2639.
6. Kirchheimer, J., Binder, B., Remold, H. (1990) Matrix-bound plasminogen activator inhibitor type 1 inhibits the invasion of human monocytes into interstitial tissue. J. Immunol. 145, 1518-1522.
7. Gyetko, M., Todd, R., III, Wilkinson, C., Sitrin, R. (1994) The urokinase receptor is required for monocyte chemotaxis in vitro. J. Clin. Invest. 93, 1380-1387.
8. Chapman, H.A., Reilly, J.J., Kobzik, L. (1988) Role of plasminogen activator in degradation of extracellular matrix proteins by live human alveolar macrophages. Am. Rev. Respir. Dis. 137, 412-419.
9. Keski-Oja, J., Lyons, R.M., Moses, H.L. (1987) Inactive secreted forms of transforming growth factor β: activation by proteolysis. J. Cell Biochem. [Suppl.] 11A, 60.
10. Naldini, L., Tamagnone, L., Vigna, E., Sachs, M., Hartmann, G., Birchmeier, W., Daikuhara, Y., Tsubouchi, H., Blasi, F., Comoglio, P. (1992) Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J. 11, 4825-4833.
11. Matsushima, K., Taguchi, M., Kovacs, E.J., Young, H.A., Oppenheim, J.J. (1986) Intracellular localization of human monocyte associated interleukin-1 (IL-1) activity and release of biologically active IL-1 from monocytes by trypsin and plasmin. J. Immunol. 136, 2883-2891.
12. Cao, D., Mizukami, I., Garni-Wagner, B., Kindzelskii, A., Todd, R., III, Boxer, L., Petty, H. (1995) Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release: possible roles of complement receptor type III and calcium. J. Immunol. 154, 1817-1829.
13. Dumler, I., Petri, T., Schleuning, W. (1993) Interaction of urokinase-type plasminogen activator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38 kDa protein. FEBS Lett. 322, 37-40.
14. Nusrat, A., Chapman, H. (1991) An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J. Clin. Invest. 87, 1091-1097.
15. Wei, Y., Waltz, D., Rao, N., Drummond, R., Rosenberg, S., Chapman, H. (1994) Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. Biol. Chem. 269, 32380-32388.
16. Fan, S., Edgington, T. (1993) Integrin regulation of leukocyte inflammatory functions: CD11b/CD18 enhancement of the tumor necrosis factor-α responses of monocytes. J. Immunol. 150, 2972-2980.
17. Gross, T., Sitrin, R. (1990) The THP-1 cell line is a urokinase-secreting mononuclear phagocyte with a novel defect in the production of plasminogen activator inhibitor-2. J. Immunol. 144, 1873-1879.
18. Scuderi, P. (1989) Suppression of human leukocyte tumor necrosis factor secretion by the serine protease inhibitor p-toluenesulfonyl-L-arginine methyl ester (TAME). J. Immunol. 143, 168-173.
19. Nu, A., Sone, S., Orino, E., Ogura, T. (1993) Induction of a 26-kDa membrane-form tumor necrosis factor (TNF)-α in human alveolar macrophages. J. Leukoc. Biol. 53, 29-36.
20. Beutler, B. (1995) TNF, immunity, and inflammatory disease: lessons of the past decade. J. Invest. Med. 43, 227-235.
21. Deutsch, D.G., Mertz, E.T. (1970) Plasminogen: purification from human plasma by affinity chromatography. Science 170, 1095-1099.
22. Coleman, P.L., Green, G.D.J. (1981) A sensitive, coupled assay for plasminogen activator using a thiol ester substrate for plasmin. Ann. N.Y. Acad. Sci. 370, 617-626.
23. Chapman, H.A., Stone, O.L., Vavrin, Z. (1984) Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. J. Clin. Invest. 73, 806-815.
24. Min, H., Semnani, R., Mizukami, I., Watt, K., Todd, R., III, Liu, D. (1992) cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. J. Immunol. 148, 3636-3642.
25. Mizukami, I., Vinjamuri, S., Trochelman, R., Todd, R., III (1990) A structural characterization of the Mo3 activation antigen expressed on the plasma membrane of human mononuclear phagocytes. J. Immunol. 144, 1841-1848.
26. Standiford, T., Kunkel, S., Kasahara, K., Milia, M., Rolfe, M., Strieter, R. (1991) Interleukin-8 gene expression from human alveolar macrophages: the role of adherence. Am. J. Respir. Cell. Mol. Biol. 5, 579-585.
27. Strieter, R., Remick, D., Lynch, J., Genord, M., Raiford, C., Spengler, R., Kunkel, S. (1989) Differential regulation of tumor necrosis factor-alpha in human alveolar macrophages and peripheral blood monocytes: a cellular and molecular analysis. Am. J. Respir. Cell. Mol. Biol. 1, 57-63.
28. Feinberg, A.P., Vogelstein, B. (1983) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132, 6-13.
29. Zar, J.H. (1984) Biostatistical Analysis. Prentice-Hall, Englewood Cliffs, NJ.
30. Reinartz, J., Batrla, R., Boukamp, P., Fusenig, N., Kramer, M. (1993) Binding and activation of plasminogen at the surface of human keratinocytes. Exp. Cell. Res. 208, 197-208.
31. Høyer-Hansen, G., Rønne, E., Solberg, H., Behrendt, N., Ploug, M., Lund, L., Ellis, V., Danø, K. (1992) Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain. J. Biol. Chem. 267, 18224-18229.
32. Hekman, C., Loskutoff, D. (1985) Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J. Biol. Chem. 260, 11581-11587.
33. Vassalli, J., Belin, D. (1987) Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett. 214, 187-191.
34. Rolfe, M., Kunkel, S., Rowens, B., Standiford, T., Cragoe, E., Jr., Strieter, R. (1992) Suppression of human alveolar macrophage-derived cytokines by amiloride. Am. J. Respir. Cell. Mol. Biol. 6, 576-582.
35. Olson, D., Pöllänen, J., Høyer-Hansen, G., Rønne, E., Sakaguchi, K., Wun, T., Appella, E., Danø, K., Blasi, F. (1992) Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor. J. Biol. Chem. 267, 9129-9133.
36. Ploug, M., Rønne, E., Behrendt, N., Jensen, A., Blast, F., Danø, K. (1991) Cellular receptor for urokinase plasminogen activator: carboxy-terminal processing and membrane anchoring by glycosylphosphatidylinositol. J. Biol. Chem. 266, 1926-1933.
37. Strieter, R., Chensue, S., Basha, M., Standiford, T., Lynch, J., Baggiolini, M., Kunkel, S. (1990) Human alveolar macrophage gene expression of interleukin-8 by tumor necrosis factor-α, lipopolysaccharide, and interleukin-1β. Am. J. Respir. Cell. Mol. Biol. 2, 321-326.
38. Martich, G., Danner, R., Ceska, M., Suffredini, A. (1991) Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effects of antiinflammatory agents. J. Exp. Med. 173, 1021-1024.
39. Keski-Oja, J., Lohi, J., Tuuttila, A., Tryggvason, K., Vartio, T. (1992) Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator. Exp. Cell Res. 202, 471-476.
40. Quigley, J., Gold, L., Schwimmer, R., Sullivan, L. (1987) Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells. Proc. Natl. Acad. Sci. USA 84, 2776-2780.
41. Gold, L., Rostagno, A., Frangione, B., Passalaris, T. (1992) Localization of the cleavage sites on fibronectin following digestion by urokinase. J. Cell. Biochem. 50, 441-452.
42. Beezhold, D., Personius, C. (1992) Fibronectin fragments stimulate tumor necrosis factor secretion by human monocytes. J. Leukoc. Biol. 51, 59-64.
43. Jones, A., Geczy, C. (1990) Thrombin and factor Xa enhance the production of interleukin-1. Immunology 71, 236-241.
44. Altieri, D., Edgington, T. (1990) Identification of effector cell protease receptor-1. J. Immunol. 145, 246-253.
45. Bar-Shavit, R., Benezra, M., Sabbah, V., Bode, W., Vlodavsky, I. (1992) Thrombin as a multifunctional protein: induction of cell adhesion and proliferation. Am. J. Respir. Cell. Mol. Biol. 6, 123-130.
46. Saksela, O., Rifkin, D. (1990) Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity. J. Cell Biol. 110, 767-775.
47. McGeehan, G., Becherer, J., Bast, R., Jr., Boyer, C., Champion, B., Connolly, K., Conway, J., Furdon, P., Karp, S., Kidao, S., McElroy, A., Nichols, J., Pryzwansky, S., Schoenen, F., Sekut, L., Truesdale, A., Verghese, M., Warner, J., Ways, J. (1994) Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor. Nature 370, 558-561.
48. Idell, S., James, K.K., Levin, E.G., Schwartz, B.S., Manchanda, N., Maunder, R.J., Martin, T.R., McLarty, J., Fair, D.S. (1989) Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J. Clin. Invest. 84, 695-705.
49. Bertozzi, P., Astedt, B., Zenzius, L., Lynch, K., LeMaire, F., Zapol, W., Chapman, H.A. (1990) Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N. Engl. J. Med. 322, 890-897.
50. Izaki, S., Isozaki, Y., Satoh, M., Hibino, T., Kon, S., Izaki, M. (1983) Comparative study with two polar types of murine leprosy: an involvement of plasminogen activator and its possible regulating factor in the granulumatous tissue reaction. J. Invest. Dermatol. 80, 81-85.
51. Sitrin, R.G., Brubaker, P., Fantone, J.C. (1986) Tissue fibrin deposition during acute lung injury in rabbits and its relationship to local expression of procoagulant and fibrinolytic activities. Am. Rev. Respir. Dis. 135, 930-936.
52. Colucci, M., Paramo, J., Collen, D. (1985) Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation. J. Clin. Invest. 75, 818-824.
53. Cohen, S.D., Israil, E., Spiess-Meier, B., Wainberg, M.A. (1981) Plasminogen activator is an apparent lymphocyte mitogen. J. Immunol. 126, 1415-1420.
54. Goeken, N., Staggs, T., Ballas, Z. (1989) Monocyte suppressor factor is plasminogen activator inhibitor inhibition of membrane bound but not soluble IL-1. J. Immunol. 143, 603-608.
55. Miller, C.L., Graziano, C.J., Lim, R.C. (1982) Human monocyte plasminogen activator production: correlation to altered Mφ-T lymphocyte interaction. J. Immunol. 128, 2194-2200.