Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu298→Asp polymorphism) to the presence, extent, and severity of coronary artery disease

Heart

Volumn 87, Issue 6, 2002, Pages 525-528

  Colombo, Maria Giovanna ^a   Andreassi, M G ^a   Paradossi, U ^a   Botto, N ^a   Manfredi, S ^a   Masetti, S ^a   Rossi, G ^a   Clerico, A ^a   Biagini, A ^a  

^a G PASQUINUCCI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; GLUTAMINE; NITRIC OXIDE SYNTHASE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SCORING SYSTEM; STENOSIS;

EID: 0036112444     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/heart.87.6.525     Document Type: Article

References (32)

1. Interactions of the major risk factors for coronary heart disease
2. Clinical misconceptions dispelled by epidemiological research
3. Prediction of coronary heart disease using risk factors categories
4. Genetic susceptibility to death from coronary heart disease in a study of twins
5. Genetic analysis of atherosclerosis: A research paradigm for the common diseases
6. Regulatory functions of the vascular endothelium
7. The L-arginine-nitric oxide pathway
8. NO at work
9. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits
10. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
11. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
12. A common variant of the endothelial nitric oxide synthase (Glu298→Asp) is a major risk factor for coronary artery disease in the UK
13. Determinants of early versus late cardiac death in patients undergoing coronary artery bypass graft surgery
14. A common variant of endothelial nitric oxide synthase (Glu298Asp) is an independent risk factor for carotid atherosclerosis
15. K. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction
16. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction
17. The Glu298→Asp (894G→T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease
18. Polymorphisms of the endothelial nitric oxide synthase gene - No consistent association with myocardial infarction in the ECTIM study
19. Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma
20. Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction
21. Atherosclerosis: An inflammatory disease
22. Endothelial dysfunctions: Common denominators in vascular disease
23. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
24. Glutamate-459 is important for Escherichia coli branching enzyme activity
25. G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine
26. Endothelial nitric oxide synthase gene polymorphism and maternal vascular adaptation to pregnancy
27. Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase
28. In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism
29. T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm
30. Genetic risk factors for coronary artery spasm: Significance of endothelial nitric oxide synthase gene T-786→C and missense Glu298Asp variants
31. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity