Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma

Stroke

Volumn 29, Issue 9, 1998, Pages 1908-1911

  Markus, Hugh S ^a,b   Ruigrok, Ynte ^a   Ali, Nadira ^a   Powell, John F ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Atherosclerosis; Cerebrovascular disorders; Genetics; Nitric oxide; Risk factors

Indexed keywords

NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; ATHEROMA; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; COMPUTER ASSISTED TOMOGRAPHY; DNA POLYMORPHISM; EXON; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSIENT ISCHEMIC ATTACK;

EID: 0031711925     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.29.9.1908     Document Type: Article

References (28)

1. Brass LM, Issacsohn JL, Merikangas KR, Robinette CD. A study of twins and stroke. Stroke. 1992;23:221-223.
2. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab. 1994;14:175-192.
3. White RP, Deane C, Vallance P, Markus HS. Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia. Stroke. 1998;29:467-472.
4. Ayata C, Ma JY, Meng W, Huang PL, Moskowitz MA. L-NA-sensitive rCBF augmentation during vibrissal stimulation in type-III nitric-oxide synthase mutant mice. J Cereb Blood Flow Metab. 1996;16:539-541.
5. Radomski MW, Palmer RMJ, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987; 2:1057-1058.
6. Radomski M, Palmer RMJ, Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A. 1990;87:5193-5197.
7. Samdani AF, Dawson TM, Dawson VL. Nitric oxide synthase in models of focal ischemia. Stroke. 1997;28:1283-1288.
8. Strandgaard S, Olesen J, Skinhoj E, Lassen NA. Autoregulation of brain circulation in severe arterial hypertension. BMJ. 1973;1:507-510.
9. Calver A, Collier J, Vallance P. Forearm blood flow responses to a nitric oxide synthase inhibitor in patients with treated essential hypertension. Cardiovasc Res. 1994;28:1720-1725.
10. Calver A, Collier J, Vallance P. Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest. 1992;90:2548-2554.
11. Gilligan DM, Guetta V, Panza JA, Garcia CE, Quyyumi AA, Cannon RO. Selective loss of microvascular endothelial function in human hypercholesterolemia. Circulation. 1994;90:35-41.
12. Janssens SP, Shimouchi A, Quetermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem. 1992:267:14519-14522.
13. Nadaud S, Bonnardeaux A, Lathrop GM, Soubrier F. Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun. 1994;198:1027-1033.
14. Marsden PA, Heng HH, Scherer SW, Stewart RJ, Hall AV, Shi XM, Tsui LC, Schappert KT. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 1993; 268:17478-17488.
15. Hingorani AD, Liang CF, Fatibene J, Parsons A, Hooper RV. Trutwein D, Stephens NG. O'Shaughnessy KM, Brown MJ. A common variant of the nitric oxide synthase gene is a risk factor for coronary atherosclerosis in the east Anglian region of the UK. Circulation. 1997:96:SS-3050. Abstract.
16. Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, McMahan MR, Thompson CJ, Heiss G, Crouse JR. Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis: a case-control study. Circulation. 1990:82:1230-1242.
17. Barley J, Blackwood A, Carter ND, Crews DE, Cruickshank JK, Jeffery S, Ogunlesi AO, Sagnella GA. Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin. J Hypertens. 1994;12:955-957.
18. Pullicino PM, Caplan LR, Hommel M. Cerebral Small Artery Disease. New York. NY: Raven Press; 1993.
19. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz M, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377:239-242.
20. Bonnardeaux A, Nadaud S, Charru A, Jeunemaitre X, Corvol P, Soubrier F. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation. 1995;91:96-102.
21. Hunt SC, Williams CS, Sharma AM, Inoue I, Lalouel JM. Lack of linkage between the endothelial nitric oxide synthase gene and hypertension. J Human Hypertens. 1996;10:27-30.
22. Nakayama T, Soma M, Takahashi Y, Izumi Y, Kanmatsuse K, Esumi M. Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese. Clin Genet. 1997;51:26-30.
23. Nakayama T, Soma M, Izumi Y, Kanmatsuse K, Esumi M. CA repeat polymorphism of the endothelial nitric oxide synthase gene in the Japanese. Hum Hered. 1995;45:301-302.
24. Arngrimsson R, Hayward C, Nadaud S, Baldursdottir A, Walker JJ, Liston WA, Bjarnadottir RI, Brock DJ, Geirsson RT, Connor JM, Soubrier F. Evidence for a familial pregnancy induced hypertension locus in the eNOS-gene region. Am J Hum Genet. 1997;61:354-362.
25. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
26. Wang XL, Sim AS, Badenhop RF, McCredie RM, Wilcken DEL. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nature Med. 1996;2:41-45.
27. Powell FT, Higman DJ. Smoking, nitric oxide and the endothelium. Br J Surf. 1994;81:785-787.
28. Tsukada T, Yokoyama K, Arai T, Takemoto F, Hara S, Yamada A, Kawaguchi Y, Hosoya T, Igari J. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun. 1998;245:190-193.