Regulating the 26S proteasome

Current Topics in Microbiology and Immunology

Volumn 268, Issue , 2002, Pages 43-72

  Glickman, M H ^a   Maytal, V ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROTEASOME; UBIQUITIN;

AMINO ACID SEQUENCE; DNA REPAIR; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REVIEW;

EUKARYOTA;

EID: 0036097879     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-59414-4_3     Document Type: Review

References (166)

1. Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity
2. Structural and functional effects of PA700 and modulator protein on proteasomes
3. Unscrambling the puzzle of biological machines: The importance of details
4. Structure and dynamics of molecular motors
5. Homologues of 26S proteasome subunits are regulators of transcription and translation
6. Assembly of the 26S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity
7. Conservation and diversity of eukaryotic translation initiation factor 3
8. Degradation of the Epstein-Barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway, targeting via ubiquitination of the N-terminal residue
9. Surface hydrophobic residues of multi-ubiquitin chains essential for proteolytic targeting
10. The hydrophobic effect contributes to polyubiquitin chain recognition
11. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase
12. Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70
13. Sequence analysis of the AAA protein family
14. The proteasome
15. Degradation of Id proteins by the ubiquitin-proteasome pathway
16. kip1 functions as an anergy factor inhibiting interleukin2 transcription and clonal expansion of alloreactive human and mouse T lymphocytes
17. The base of the proteasome regulatory particle exhibits chaperone-like activity
18. A novel site for ubiquitination: The N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein
19. Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome
20. The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant development switch
21. JABI interacts with both the progesterone receptor and SRC-1
22. Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly
23. Ubiquitin-mediated proteolysis: Biological regulation via destruction
24. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
25. Interaction between ICSBP and CSN2 (Trip15) - A possible link between IRF signaling and the COP9/Signalosome
26. The 26S proteasome: Regulation and substrate recognition
27. Developmental changes of the 26S proteasome in abdominal intersegmental muscles of Manduca sexta during programmed cell death
28. Proteasomes and other self-compartmentalizing proteases in prokaryotes
29. PA700, an ATP-dependent activator of the 20S proteasome, is an ATPase containing multiple members of a nucleotide binding protein family
30. Identification, purification, and characterization of a PA700-dependent activator of the proteasome
31. Unified nomenclature for the COP9 signalosome: An essential regulator of development
32. Molecular cloning and expression of a 26S proteasome subunit enriched in dileucine repeats
33. Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants
34. Subunits of the regulatory complex of the 26S proteasome
35. Purification of an 11S regulator of the multicatalytic protease
36. The human 26S and 20S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrates
37. Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast
38. Regulatory subunit interactions of the 26S proteasome, a complex problem
39. Unified nomenclature for subunits of the S. cerevisiae proteasome regulatory particle
40. Interferon regulatory factor 1 mediates the interferon-gamma induction of the human immunoproteasome subunit MECL-1
41. The COP9 complex is essential for development of Drosophila melanogaster
42. Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26S proteasome subunit Mcb1
43. Growth-dependent change of the 26S proteasome in budding yeast
44. Son1p is a component of the 26S proteasome of the yeast Sacharomyces cerevisiae
45. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
46. Multiubiquitin chain binding subunit MCB1 (RPN10) of the 26S proteasome is essential for developmental progression in Physcomitrella patens
47. Getting in and out of the proteasome
48. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9/Signalosome and eIF3
49. The regulatory particle of the S. cerevisiae proteasome
50. Mapping subunit contacts in the regulatory complex of the 26S proteasome
51. Regulatory subunits of energy-dependent proteases
52. Protein quality control: Triage by chaperones and proteases
53. A gated channel into the core particle of the proteasome
54. Structure of 20S proteasome from yeast at a 2.4 Angstrom resolution
55. Mapping the ubiquitin-binding domains in the p54 regulatory complex subunit of the Drosophila 26S protease
56. Simultaneous binding of PA28 and PA700 activators to 20S proteasomes
57. The ubiquitin system
58. ATP-dependent degradation of ubiquitin-protein conjugates
59. The generation of nfkb2 p52: Mechanism and efficiency
60. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
61. Interaction of hHR23 with s5a
62. The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme
63. Activation of the multicatalytic protease
64. The PCI domain: A common theme in three multi-protein complexes
65. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair
66. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal degradation systems
67. A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20S proteasome
68. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
69. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome
70. Chaperone rings in protein folding and degradation
71. Ubiquitin-lysozyme conjugates
72. Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4
73. Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets
74. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome
75. The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex
76. Range of sizes of peptide products generated during degradation of different proteins by Archaeal proteasomes
77. The size of peptides generated from protein by mammalian 26S and 20S proteasomes
78. The hPLIC proteins may provide a link between the Ubiquitination machinery and the proteasome
79. Inactivation of the 20S poteasome in Mycobacterium smegmatis
80. Modes of regulation of ubiquitin-mediated protein degradation
81. An algorithm for the prediction of proteasomal cleavages
82. Characterisation of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex
83. Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of the 26S proteasome
84. Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome
85. Pleiotropic defects caused by loss of the proteasomal-interacting factors Rad23 and Rpn10 of S. cerevisiae
86. Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes
87. Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived abnormal proteins in Saccharomyces cerevisiae
88. JAB1 binds to the intracellular precursor of the lutropin/choriogonadotropin receptor and promotes its degradation
89. Identification of a 26S proteasome-associated UCH in fission yeast
90. Crystal structure of the 20S proteasome from the archeon T. acidophilum at 3.4 Angstrom resolution
91. The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome
92. A repetitive sequence in subunits of the 26S proteasome and 20S cyclosome (APC)
93. Self compartmentalizing proteases
94. Identification, purification, and characterization of a protein activator (PA28) of the 20S proteasome
95. IRFs: The next generation
96. A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways
97. Rpn4 acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast
98. Proteasomes in the archaea: From structure to function
99. A role for the ubiquitin-dependent proteolytic pathway in MHC class 1 restricted antigen presentation
100. The COP9/signalosome complex is conserved in fission yeast and has a role in S phase
101. Degradation of ODC by the 26S proteasome
102. Degradation of transcription factor IRF-1 by the ubiquitn-proteasome pathway. The C-terminal region governs protein stability
103. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK
104. Cleavage motifs of the yeast 20S proteasome beta-subunits deduced from digests of enolase 1
105. Modulation of intracellular protein degradation by SSB1-S1S1 chaperon system in yeast S. cerevisiae
106. Structural motifs involved in ubiquitin-mediated processing of the NF-κB precursor p105: Roles of the glycine-rich region and a downstream ubiquitination domain
107. A new large proteolytic complex distinct from the proteasome is present in the cytosol of fission yeast
108. The ubiquitin proteasome pathway is required for processing the NF-κB1 precursor protein and activation of NF-κB
109. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome
110. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the tre-2 oncogene
111. The AAA team: Related ATPases with diverse functions
112. Distinct 19S and 20S subcomplexes of the proteasome and their distribution in the nucleus and the cytoplasm
113. Targeting of substrates to the 26S proteasome
114. Inhibition of the 26S proteasome by polyubiquitin chains synthesized to have defined lengths
115. Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly
116. Characterization of recombinant REGα, REGβ, and REGγ proteasome activators
117. The multicatalytic and 26S proteases
118. The proteasome activator 11S REG (PA28) and class I antigen presentation
119. The ATP-dependent HslV/U protease from Escherichia coli is a four-ring structure resembling the proteasome
120. Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome
121. Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum
122. The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair
123. Subcellular localization stochiometry and protein levels of 26S proteasome subunits in yeast
124. Rapid isolation and characterization of the yeast proteasome regulatory complex
125. Rad23 links DNA repair to the ubiquitin/proteasome pathway
126. Evidence for the existence of a non-catalytic modifier site of peptide hydrolysis by the 20S proteasome
127. NF-κB p105 processing via the ubiquitin-proteasome pathway
128. HIV-1 Tat inhibits the 20S proteasome and its 11S regulator-mediated activation
129. A novel protein complex involved in signal transduction possessing similarities to the 26S proteasome subunits
130. Arabidopsis cop8 and fus4 mutations define the same locus that encodes subunit 4 of the COP9 signalosome
131. Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation
132. The ubiquitin-proteasome pathway in cancer
133. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain
134. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
135. Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone
136. Kinetic evidences for facilitation of peptide channeling by the proteasomal activator PA28
137. The function of the proteasome system in MHC class I antigen processing
138. The ubiquitin-proteasome system and endocytosis
139. The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
140. MgATP binding to the nucleotide-binding domains of the eukaryotic cytoplasmic chaperonin induces conformational changes in the putative substrate binding domains
141. The role of tricorn protease and its amino-peptidase-interacting factors in cellular protein degradation
142. Hybrid proteasomes: Induction by interferon-gamma and contribution to ATP-dependent proteolysis
143. Recognition of the polyubiquitin proteolytic signal
144. Degradation of the cyclin dependent kinaseinhibitor p27/Kip1 is instigated by Jab1
145. Nob1, a new essential protein associates with the 26S proteasome of growing S. cerevisiae cells
146. Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome
147. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
148. The multiubiquitin chain binding protein Mcb1 is a component of the 26S proteasome in S. cerevisiae and plays a nonessential, substrate-specific role in protein turnover
149. The 26S proteasome: A molecular machine designed for controlled proteolysis
150. Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
151. Protein kinase A antagonises Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
152. cDNA cloning and characterization of a human proteasomal modulator subunit p27
153. Global unfolding of a substrate protein by the Hsp100 chaperone C1pA
154. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex
155. Dynamic association of proteasomal machinery with the centrosome
156. Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn12/Mts3 activity is compromised
157. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains
158. Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome
159. Biochemical and physical properties of the M. jannaschii 20S proteasome and PAN, a homolog of the ATPase (Rpt) subunits of the eucaryal 26S proteasome
160. Characterization of ARC, a divergent member of the AAA ATPase family from Rhodococcus erythropolis
161. Physical association of ubiquitin ligases and the 26S proteasome
162. Giant proteases: Beyond the proteasome
163. Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma brucei
164. Characterization of two polyubiquitin binding sites in the 26S protease subunit 5a
165. Dis-assembly lines: The proteasome and related ATPase-assisted proteases
166. An archaebacterial ATPase, homologous to ATPases in the eukaryotic 26S proteasome, activates protein breakdown by 20S proteasomes