The function of the proteasome system in MHC class I antigen processing

Immunology Today

Volumn 21, Issue 7, 2000, Pages 317-319

  Stoltze, Lars ^a   Nussbaum, Alexander K ^a   Sijts, Alice ^b   Emmerich, Niels P N ^a   Kloetzel, Peter M ^b   Schild, Hansjörg ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME;

ANTIGEN PRESENTATION; ARTICLE; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVITY; ENZYME SUBUNIT; MOUSE; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA TRANSLATION;

EID: 0034235837     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01665-0     Document Type: Conference Paper

References (9)

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2. 2 Groettrup, M. et al. (1996) A role for the proteasome regulator PA28alpha in antigen presentation. Nature 381, 166-168
3. 3 Dick, T.P. et al. (1996) Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. Cell 86, 253-262
4. 4 Preckel, T. et al. (1999) Impaired immunoproteasome assembly and immune responses in PA28-/-mice. Science 286, 2162-2165
5. 5 Morel, S. et al. (2000) Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. Immunity 12, 107-117
6. 6 Van Kaer, L. et al. (1994) Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity 1, 533-541
7. 7 Sijts, A.J.A.M. et al. (2000) Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes. J. Exp. Med. 191, 503-514
8. 8 Fehling, H.J. et al. (1994) MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265, 1234-1237
9. 9 Sijts, A.J.A.M. et al. MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells. J. Immunol. (in press).