Peripheral blood and granuloma CD4+CD28- T cells are a major source of interferon-γ and tumor necrosis factor-α in Wegener's granulomatosis

American Journal of Pathology

Volumn 160, Issue 5, 2002, Pages 1717-1724

  Komocsi, Andras ^a   Lamprecht, Peter ^a   Csernok, Elena ^a   Mueller, Antje ^a   Holl Ulrich, Konstanze ^a   Seitzer, Ulrike ^b   Moosig, Frank ^c   Schnabel, Armin ^a   Gross, Wolfgang Ludwig ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b RESEARCH CENTER BORSTEL   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD57 ANTIGEN; CELL SURFACE MARKER; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD; CELL MEDIATED CYTOTOXICITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GRANULOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; MALE; MONOCYTE; NATURAL KILLER CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; WEGENER GRANULOMATOSIS;

EID: 0036097722     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61118-2     Document Type: Article

References (43)

1. An interdisciplinary approach to the care of patients with Wegener's granulomatosis - Long term outcome of 155 patients
2. T-cell cytokine profiles in patients with Wegener's granulomatosis
3. Cytokine profiles in Wegener's granulomatosis: Predominance of type 1 (Th1) in the granulomatous inflammation
4. Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: Reversal with IL-10
5. Localized Wegener's granulomatosis: Predominance of CD26 and IFN-γ expression
6. Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy
7. Treatment of refractory Wegener's granulomatosis with humanized monoclonal antibodies
8. Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis
9. A human in vitro granuloma model using heat killed Candida albicans cells immobilized on plastic culture wells
10. TB vaccines: Progress and problems
11. + T-cell subsets in Wegener's granulomatosis
12. Costimulatory molecules in Wegener's granulomatosis (WG): Lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells
13. CD28-negative T-cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis
14. Expanded T cell populations in patients with Wegener's granulomatosis: Characteristics and correlates with disease activity
15. Recall response to cytomegalovirus in allograft recipients: Mobilization of CD57+, CD28+ cells before expansion of CD57+, CD28- cells within the CD8+ T lymphocyte compartment
16. The American College of Rheumatology criteria for the classification of Wegener's granulomatosis
17. Nomenclature of systemic vasculitides. Proposal of an international consensus conference
18. Diagnosis and evaluation of vasculitis
19. Development and validation of a disease extent index for Wegener's granulomatosis
20. Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis
21. Update on the European vasculitis study group trials
22. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes)
23. Are animal models of vasculitis suitable tools?
24. Perforin and lymphocyte-mediated cytolysis
25. Cytolytic effector mechanisms of human CD4+ cytotoxic T lymphocytes
26. Interleukin 2 and its receptors: Recent advances and new immunological functions
27. + immunoregulatory T cells that control autoimmune diabetes
28. Up-regulation of the endothelial cell adhesion molecule intercellular adhesion molecule-1 (ICMA-1) by autoantibodies in autoimmune vasculitis
29. T lymphocyte adhesion mechanisms in vasculitic glomerulonephritis
30. In situ production of TNFα, IL-1β and IL-2R in ANCA-positive glomerulonephritis
31. TNF-α production by eosinophils in upper airways inflammation (nasal polyposis)
32. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
33. Skewed maturation of memory HIV-specific CD8 T lymphocytes
34. CD45 isoform phenotypes of human T cells: CD4(+)CD45RA(-)RO(+) memory T cells re-aquire CD45RA without losing CD45RO
35. Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings
36. Functional subsets of CD4 T cells in rheumatoid synovitis
37. Co-stimulatory pathways controlling activation and peripheral tolerance in human CD4+CD28- T cells
38. T cells clonally expanded in rheumatoid arthritis
39. CD4+, CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems
40. Cytomegalovirus seropositivity is associated with the expansion of CD4+CD28- and CD8+CD28- T cells in rheumatoid arthritis
41. + T-cell population
42. + T cells during primary cytomegalovirus infection
43. Systemic cytomegalovirus infection mimicking an exacerbation of Wegener's granulomatosis