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Volumn 12, Issue 1, 2000, Pages 11-19

Are animal models of vasculitis suitable tools?

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY;

EID: 0033986121     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200001000-00003     Document Type: Review
Times cited : (25)

References (59)
  • 1
    • 0032908123 scopus 로고    scopus 로고
    • Animal models of infection-mediated vasculitis
    • 1 Dal Canto AJ, Virgin HW: Animal models of infection-mediated vasculitis. Curr Opin Rheumatol 1999, 11:17-23.
    • (1999) Curr Opin Rheumatol , vol.11 , pp. 17-23
    • Dal Canto, A.J.1    Virgin, H.W.2
  • 2
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • 2 Watanabe-Fukunaga R, Brannann CI, Copeland NG, Jenkins NA, Nagata S: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992, 356:314-317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannann, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 4
    • 0030829920 scopus 로고    scopus 로고
    • Elevated soluble fas production in SLE correlates with HLA status not with disease activity
    • 4 Rose LM, Latchman DS, Isenberg DA: Elevated soluble fas production in SLE correlates with HLA status not with disease activity. Lupus 1997, 6:717-722.
    • (1997) Lupus , vol.6 , pp. 717-722
    • Rose, L.M.1    Latchman, D.S.2    Isenberg, D.A.3
  • 6
    • 0033046191 scopus 로고    scopus 로고
    • Modulation of autoimmune disease in the MRL-lpr/lpr mouse by IL-2 and TGF-β1 gene therapy using attenuated Salmonella typhimurium as gene carrier
    • 6 Huggins ML, Huang F-P, Xu D, Lindop G, Stott DI: Modulation of autoimmune disease in the MRL-lpr/lpr mouse by IL-2 and TGF-β1 gene therapy using attenuated Salmonella typhimurium as gene carrier. Lupus 1999, 8:29-38. This study demonstrates the feasability of a novel convenient gene therapy approach based on understanding of underlying pathomechanisms, and points out the crucial influence of vector and route of application for the result of gene therapeutic intervention.
    • (1999) Lupus , vol.8 , pp. 29-38
    • Huggins, M.L.1    Huang, F.-P.2    Xu, D.3    Lindop, G.4    Stott, D.I.5
  • 7
    • 0029021257 scopus 로고
    • Modulation of disease activity in murine systemic erythematosus by cytokine gene delivery
    • 7 Raz E, Dudler J, Lotz M, Baird SM, Berry CC, Eisenberg RA, Carson DA: Modulation of disease activity in murine systemic erythematosus by cytokine gene delivery. Lupus 1995, 4:286-292.
    • (1995) Lupus , vol.4 , pp. 286-292
    • Raz, E.1    Dudler, J.2    Lotz, M.3    Baird, S.M.4    Berry, C.C.5    Eisenberg, R.A.6    Carson, D.A.7
  • 8
    • 0025289913 scopus 로고
    • Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus
    • 8 Gutierrez-Ramos JC, Andreu JL, Revilla Y, Vinuela E, Martinez C: Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus. Nature 1990, 346:271-274.
    • (1990) Nature , vol.346 , pp. 271-274
    • Gutierrez-Ramos, J.C.1    Andreu, J.L.2    Revilla, Y.3    Vinuela, E.4    Martinez, C.5
  • 9
    • 0029987334 scopus 로고    scopus 로고
    • Arteritis in a novel congenic strain of mice derived from MRL/lpr lupus mice
    • 9 Nose M, Nishimura M, Ito MR, Itoh J, Shibata T, Sugisaki T: Arteritis in a novel congenic strain of mice derived from MRL/lpr lupus mice. Am J Path 1996, 149:1763-1769.
    • (1996) Am J Path , vol.149 , pp. 1763-1769
    • Nose, M.1    Nishimura, M.2    Ito, M.R.3    Itoh, J.4    Shibata, T.5    Sugisaki, T.6
  • 11
    • 0030708809 scopus 로고    scopus 로고
    • Host modifier genes affect mouse autoimmunity induced by the lpr gene
    • 11 Wang Y, Nose M, Kamoto T, Nishimura M, Hiai H: Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol 1997, 151:1791-1798.
    • (1997) Am J Pathol , vol.151 , pp. 1791-1798
    • Wang, Y.1    Nose, M.2    Kamoto, T.3    Nishimura, M.4    Hiai, H.5
  • 12
    • 0032006599 scopus 로고    scopus 로고
    • Loci predisposing to autoimmunity in MRL-Faslpr mice
    • 12 Vidal S, Kono DH, Theofilopoulos AN: Loci predisposing to autoimmunity in MRL-Faslpr mice. J Clin Invest 1998, 101:696-702.
    • (1998) J Clin Invest , vol.101 , pp. 696-702
    • Vidal, S.1    Kono, D.H.2    Theofilopoulos, A.N.3
  • 13
    • 0032534737 scopus 로고    scopus 로고
    • Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-1prl 1pr mouse model of systemic lupus erythematosus
    • 13 Gu L, Weinreb A, Wang XP, Zack DJ, Qiao JH, Weisbart R, Lusis AJ: Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-1prl 1pr mouse model of systemic lupus erythematosus. J Immunol 1998, 161:6999-7006.
    • (1998) J Immunol , vol.161 , pp. 6999-7006
    • Gu, L.1    Weinreb, A.2    Wang, X.P.3    Zack, D.J.4    Qiao, J.H.5    Weisbart, R.6    Lusis, A.J.7
  • 14
    • 0027481688 scopus 로고
    • Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis
    • 14 Kinjoh K, Kyogoku M, Good RA: Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis. Proc Natl Acad Sci USA 1993, 90:3413-3417.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3413-3417
    • Kinjoh, K.1    Kyogoku, M.2    Good, R.A.3
  • 15
    • 0031869634 scopus 로고    scopus 로고
    • Prevention of crescentic glomerulonephritis in SCG/Kj mice by bone marrow transplantation
    • 15 Cherry NN, Engelman RW, Wang BY, Kin joh K, El-Badri NS, Good RA: Prevention of crescentic glomerulonephritis in SCG/Kj mice by bone marrow transplantation. Proc Soc Exp Biol Med 1998, 218:223-228. This study implies that the molecular genetic lesions responsible for this immunologically based disease reside in the hematopoetic stem cell compartment, and provides further rationale for the use of bone marrow transplantation to treat certain autoimmune diseases.
    • (1998) Proc Soc Exp Biol Med , vol.218 , pp. 223-228
    • Cherry, N.N.1    Engelman, R.W.2    Wang, B.Y.3    Kin Joh, K.4    El-Badri, N.S.5    Good, R.A.6
  • 17
    • 0031875778 scopus 로고    scopus 로고
    • Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti-neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp-lpr/lpr mice: A spontaneous model for human microscopic angiitis
    • 17 Harper JM, Thiru S, Lockwood CM, Cooke A: Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti-neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp-lpr/lpr mice: a spontaneous model for human microscopic angiitis. Eur J Immunol 1998, 28:2217-2226. This study indicates that the presence of MPO-ANCA modulates the disease phenotype. In addition, treatment with antimicrobial agents attenuated the severity of vasculitic lesions, implying a contributory role of infections in the pathogenesis of vasculitis.
    • (1998) Eur J Immunol , vol.28 , pp. 2217-2226
    • Harper, J.M.1    Thiru, S.2    Lockwood, C.M.3    Cooke, A.4
  • 18
    • 0025340093 scopus 로고
    • Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the brown Norway rat
    • 18 Pusey CD, Bowman C, Morgan A, Weetman AP, Hartley B, Lockwood CM: Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the brown Norway rat. Clin Exp Immunol 1990, 81:76-82.
    • (1990) Clin Exp Immunol , vol.81 , pp. 76-82
    • Pusey, C.D.1    Bowman, C.2    Morgan, A.3    Weetman, A.P.4    Hartley, B.5    Lockwood, C.M.6
  • 20
    • 0028169958 scopus 로고
    • Anti-phospholipid antibodies in the mercuric chloride treated Brown Norway rat
    • 20 Marriott JB, Qasim F, Oliveira DBG: Anti-phospholipid antibodies in the mercuric chloride treated Brown Norway rat. J Autoimmun 1994, 7:457-467.
    • (1994) J Autoimmun , vol.7 , pp. 457-467
    • Marriott, J.B.1    Qasim, F.2    Oliveira, D.B.G.3
  • 21
    • 0026734809 scopus 로고
    • Mercuric chloride-treated brown Norway rats develop widespread tissue injury including necrotizing vasculitis
    • 21 Mathieson PW, Thiru S, Oliveira DB: Mercuric chloride-treated brown Norway rats develop widespread tissue injury including necrotizing vasculitis. Lab Invest 1992, 67:121-129.
    • (1992) Lab Invest , vol.67 , pp. 121-129
    • Mathieson, P.W.1    Thiru, S.2    Oliveira, D.B.3
  • 25
    • 0027339525 scopus 로고
    • high T cells in mercury-induced autoimmunity in the Brown Norway rat
    • high T cells in mercury-induced autoimmunity in the Brown Norway rat. J Exp Med 1993, 177:1309-1316.
    • (1993) J Exp Med , vol.177 , pp. 1309-1316
    • Mathieson, P.W.1    Thiru, S.2    Oliveria, D.B.G.3
  • 26
    • 0028910260 scopus 로고
    • Cyclosporin A exacerbates mercuric chloride-induced vasculitis in the Brown Norway rat
    • 26 Qasim FJ, Mathieson PW, Thiru S, Oliveira DB: Cyclosporin A exacerbates mercuric chloride-induced vasculitis in the Brown Norway rat. Lab Invest 1995, 72:183-190.
    • (1995) Lab Invest , vol.72 , pp. 183-190
    • Qasim, F.J.1    Mathieson, P.W.2    Thiru, S.3    Oliveira, D.B.4
  • 27
    • 0028913712 scopus 로고
    • The time course and characterization of mercuric chloride-induced immunopathology in the Brown Norway rat
    • 27 Qasim FJ, Thiru S, Mathieson PW, Oliveira DBG: The time course and characterization of mercuric chloride-induced immunopathology in the Brown Norway rat. J Autoimmun 1995, 8:193-208.
    • (1995) J Autoimmun , vol.8 , pp. 193-208
    • Qasim, F.J.1    Thiru, S.2    Mathieson, P.W.3    Oliveira, D.B.G.4
  • 28
    • 0031573225 scopus 로고    scopus 로고
    • Mercuric chloride-induced vasculitis in the Brown Norway rat: αβ T cell-dependent and independent phases
    • 28 Kiely PDW, Pecht I, Oliveira DBG: Mercuric chloride-induced vasculitis in the Brown Norway rat: αβ T cell-dependent and independent phases. J Immunol 1997, 159:5100-5106.
    • (1997) J Immunol , vol.159 , pp. 5100-5106
    • Kiely, P.D.W.1    Pecht, I.2    Oliveira, D.B.G.3
  • 30
    • 0029097716 scopus 로고
    • Compounds that induce autoimmunity in the Brown Norway rat sensitize mat cells for mediator release and interleukin-4 expression
    • 30 Oliveira DBG, Gillespie K, Wolfreys K, Mathieson PW, Qasim F, Coleman JW: Compounds that induce autoimmunity in the Brown Norway rat sensitize mat cells for mediator release and interleukin-4 expression. Eur J Immunol 1995, 25:2259-2264.
    • (1995) Eur J Immunol , vol.25 , pp. 2259-2264
    • Oliveira, D.B.G.1    Gillespie, K.2    Wolfreys, K.3    Mathieson, P.W.4    Qasim, F.5    Coleman, J.W.6
  • 32
    • 0028900338 scopus 로고
    • Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidae-associated proliferate glomerlonephritis
    • 32 Brouwer E, Klok PA, Huitema MG, Weening JJ, Kallenberg CGM: Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidae-associated proliferate glomerlonephritis. Kidney Int 1995, 47:1121-1129.
    • (1995) Kidney Int , vol.47 , pp. 1121-1129
    • Brouwer, E.1    Klok, P.A.2    Huitema, M.G.3    Weening, J.J.4    Kallenberg, C.G.M.5
  • 33
    • 0027999048 scopus 로고
    • Immune complex glomerulonephritis is induced in rats immunized with heterologous myeloperoxidase
    • 33 Yang JJ, Jennette JC, Falk RJ: Immune complex glomerulonephritis is induced in rats immunized with heterologous myeloperoxidase. Clin Exp Immunol 1994, 97:466-473.
    • (1994) Clin Exp Immunol , vol.97 , pp. 466-473
    • Yang, J.J.1    Jennette, J.C.2    Falk, R.J.3
  • 36
    • 0031951557 scopus 로고    scopus 로고
    • Expression of iNOS, eNos, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis
    • 36 Heeringa P, van Goor H, Moshage H, Klok PA, Huitema MG, de Jager A. Schep AJ, Kallenberg CG: Expression of iNOS, eNos, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis. Kidney Int 1998, 53:382-393.
    • (1998) Kidney Int , vol.53 , pp. 382-393
    • Heeringa, P.1    Van Goor, H.2    Moshage, H.3    Klok, P.A.4    Huitema, M.G.5    De Jager, A.6    Schep, A.J.7    Kallenberg, C.G.8
  • 37
    • 0032844269 scopus 로고    scopus 로고
    • Anti-myeloperoxidase-associated lung disease: An experimental model
    • 37 Foucher P, Heeringa P, Petersen AH, Huitema MG, Brouwer E, Cohen Tervaert JW, Prop J, Camus P, Weening JJ, Kallenberg CG: Anti-myeloperoxidase-associated lung disease: an experimental model. Am J Respir Crit Care Med 1999, 160:987-994. This recent study confirms that immunization of Brown Norway rats with human MPO reproducibly results in circulating rat anti-human MPO antibodies that crossreact with rat MPO, and that localized tissue perfusion with neutrophil granule extracts results in tissue injury at the site of reperfusion, ie, in this case in the lung.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 987-994
    • Foucher, P.1    Heeringa, P.2    Petersen, A.H.3    Huitema, M.G.4    Brouwer, E.5    Cohen Tervaert, J.W.6    Prop, J.7    Camus, P.8    Weening, J.J.9    Kallenberg, C.G.10
  • 38
    • 0028929433 scopus 로고
    • Aggravation of rat nephrotoxic serum nephritis by anti-myeloperoxidase antibodies
    • 38 Kobayashi K, Shibata T, Sugisaki S: Aggravation of rat nephrotoxic serum nephritis by anti-myeloperoxidase antibodies. Kidney Int 1995, 47:454-463.
    • (1995) Kidney Int , vol.47 , pp. 454-463
    • Kobayashi, K.1    Shibata, T.2    Sugisaki, S.3
  • 39
    • 0029092391 scopus 로고
    • Anti-neutrophil cytoplasm antibodies and anti-glomerular basement membrane antibodies: Two coexisting distinct autoreactivities detectable in patients with rapidly progressive glomerulonephritis
    • 39 Short AK, Esnault VLM, Lockwood CM: Anti-neutrophil cytoplasm antibodies and anti-glomerular basement membrane antibodies: two coexisting distinct autoreactivities detectable in patients with rapidly progressive glomerulonephritis. Am J Kidney Dis 1995, 26:439-445.
    • (1995) Am J Kidney Dis , vol.26 , pp. 439-445
    • Short, A.K.1    Esnault, V.L.M.2    Lockwood, C.M.3
  • 40
    • 0025320149 scopus 로고
    • Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis
    • 40 Jayne DRW, Marshall PD, Jones SJ, Lockwood CM: Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis. Kidney Int 1990, 37:956-970.
    • (1990) Kidney Int , vol.37 , pp. 956-970
    • Jayne, D.R.W.1    Marshall, P.D.2    Jones, S.J.3    Lockwood, C.M.4
  • 41
    • 0025738460 scopus 로고
    • Prognostic implication of anti-neutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in anti-glomerular basement membrane disease
    • 41 Bosch X, Mirapeix E, Font J, Borrellas X, Rodriguez R, Lopez-Soto A, Ingelmo M, Revert L: Prognostic implication of anti-neutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in anti-glomerular basement membrane disease. Clin Nephrol 1991, 36:107-113.
    • (1991) Clin Nephrol , vol.36 , pp. 107-113
    • Bosch, X.1    Mirapeix, E.2    Font, J.3    Borrellas, X.4    Rodriguez, R.5    Lopez-Soto, A.6    Ingelmo, M.7    Revert, L.8
  • 42
    • 0026621203 scopus 로고
    • Anti-neutrophil cytoplasm antibodies, anti-GBM antibodies and anti-dsDNA antibodies in glomerulonephrtitis
    • 42 Bygren P, Rasmussen N, Isaksson B, Wieslander J: Anti-neutrophil cytoplasm antibodies, anti-GBM antibodies and anti-dsDNA antibodies in glomerulonephrtitis. Eur J Clin Invest 1992, 22:783-792.
    • (1992) Eur J Clin Invest , vol.22 , pp. 783-792
    • Bygren, P.1    Rasmussen, N.2    Isaksson, B.3    Wieslander, J.4
  • 43
    • 0029801153 scopus 로고    scopus 로고
    • IL-1b production by human polymorphonuclear leucocytes stimulated by anti-neutrophil cytoplasmic autoantibodies: Relevance to systemic vasculitis
    • 43 Brooks CJ, King WJ, Radford DJ, Adu D, McGrath M, Savage COS: IL-1b production by human polymorphonuclear leucocytes stimulated by anti-neutrophil cytoplasmic autoantibodies: relevance to systemic vasculitis. Clin Exp Immunol 1996, 106:273-279.
    • (1996) Clin Exp Immunol , vol.106 , pp. 273-279
    • Brooks, C.J.1    King, W.J.2    Radford, D.J.3    Adu, D.4    McGrath, M.5    Savage, C.O.S.6
  • 44
    • 0029410785 scopus 로고
    • Antibodies to neutrophil cytoplasmic antigens induce monocyte chemoattractant protein-1 secretion from human monocytes
    • 44 Casselman BL, Kilgore KS, Miller BF, Warren JS: Antibodies to neutrophil cytoplasmic antigens induce monocyte chemoattractant protein-1 secretion from human monocytes. J Lab Clin Med 1995, 126:495-502.
    • (1995) J Lab Clin Med , vol.126 , pp. 495-502
    • Casselman, B.L.1    Kilgore, K.S.2    Miller, B.F.3    Warren, J.S.4
  • 45
    • 0030779006 scopus 로고    scopus 로고
    • Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release: Role of surface proteinase-3, α1-antitrypsin, and Fcγ receptors
    • 45 Ralston DR, Marsh CB, Lowe MP, Wewers MD: Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release: role of surface proteinase-3, α1-antitrypsin, and Fcγ receptors. J Clin Invest 1997, 100:1416-1424.
    • (1997) J Clin Invest , vol.100 , pp. 1416-1424
    • Ralston, D.R.1    Marsh, C.B.2    Lowe, M.P.3    Wewers, M.D.4
  • 47
    • 0026663398 scopus 로고
    • Induction of primary antiphospholipid syndrome in mice by immunzation with human monoclonal anti-cardiolipin antibody (H-3)
    • 47 Bakimer R, Fishman P, Blank M, Sredni B, Djaldetti M, Shoenfeld Y: Induction of primary antiphospholipid syndrome in mice by immunzation with human monoclonal anti-cardiolipin antibody (H-3). J Clin Invest 1992, 89:1558-1563.
    • (1992) J Clin Invest , vol.89 , pp. 1558-1563
    • Bakimer, R.1    Fishman, P.2    Blank, M.3    Sredni, B.4    Djaldetti, M.5    Shoenfeld, Y.6
  • 49
    • 0028867562 scopus 로고
    • Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration
    • 49 Blank M, Tomer Y, Stein M, Koplovic J, Wiik A, Meroni PL, Conforti G, Shoenfeld Y: Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration. Clin Exp Immunol 1995, 102:120-130.
    • (1995) Clin Exp Immunol , vol.102 , pp. 120-130
    • Blank, M.1    Tomer, Y.2    Stein, M.3    Koplovic, J.4    Wiik, A.5    Meroni, P.L.6    Conforti, G.7    Shoenfeld, Y.8
  • 52
    • 0030967341 scopus 로고    scopus 로고
    • Finding a valid model for antineutrophil cytoplasmic antibody-related vasculitis: Comment on the article by Tomer et al and the letter by Langford and Sneller
    • 52 Béliveau A, Dagenais P, Ménard HA: Finding a valid model for antineutrophil cytoplasmic antibody-related vasculitis: comment on the article by Tomer et al and the letter by Langford and Sneller. Arthritis Rheum 1997, 40:986-990.
    • (1997) Arthritis Rheum , vol.40 , pp. 986-990
    • Béliveau, A.1    Dagenais, P.2    Ménard, H.A.3
  • 53
    • 0030186728 scopus 로고    scopus 로고
    • Finding a valid model for human Wegener's granulomatosis: Comment on the article by Tomer et al
    • 53 Langford CA, Sneller MC: Finding a valid model for human Wegener's granulomatosis: comment on the article by Tomer et al. Arthritis Rheum 1996, 39:1262-1266.
    • (1996) Arthritis Rheum , vol.39 , pp. 1262-1266
    • Langford, C.A.1    Sneller, M.C.2
  • 54
    • 0343051991 scopus 로고    scopus 로고
    • Cloning and functional expression of the murine homologue of proteinase 3: Implications for the design of murine models of vasculitis
    • 54 Jenne DE, Fröhlich L, Hummel AM, Specks U: Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis. FEBS Lett 1997, 408:187-190.
    • (1997) FEBS Lett , vol.408 , pp. 187-190
    • Jenne, D.E.1    Fröhlich, L.2    Hummel, A.M.3    Specks, U.4
  • 58
    • 0030961240 scopus 로고    scopus 로고
    • Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras
    • 58 Brack A, Rittner HL, Younge BR, Kaltschmidt C, Weyand CM, Goronzy JJ: Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras. J Clin Invest 1997, 99:2842-2850.
    • (1997) J Clin Invest , vol.99 , pp. 2842-2850
    • Brack, A.1    Rittner, H.L.2    Younge, B.R.3    Kaltschmidt, C.4    Weyand, C.M.5    Goronzy, J.J.6
  • 59
    • 0032947546 scopus 로고    scopus 로고
    • Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis
    • 59 Rittner HL, Hafner V, Klimiuk PA, Szweda LI, Goronzy JJ, Weyand CM: Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. J Clin Invest 1999, 103:1007-1013. This study confirms the reproducibility of the CGA-SCID mouse chimera and its utility for the study of cellular and molecular mechanisms of tissue injury and novel therapeutic strategies in giant cell arteritis.
    • (1999) J Clin Invest , vol.103 , pp. 1007-1013
    • Rittner, H.L.1    Hafner, V.2    Klimiuk, P.A.3    Szweda, L.I.4    Goronzy, J.J.5    Weyand, C.M.6


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