A simple screen for murein transglycosylase inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 5, 2000, Pages 1181-1185

  Vollmer, Waldemar ^a,b   Höltje, Joachim Volker ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAMBERMYCIN; GLYCOSYLTRANSFERASE INHIBITOR; PENICILLIN BINDING PROTEIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; DRUG DETERMINATION; DRUG SCREENING; ESCHERICHIA COLI; GLYCOSYLATION; NONHUMAN; PRIORITY JOURNAL;

BACTERIAL PROTEINS; BAMBERMYCINS; BINDING, COMPETITIVE; CARBOHYDRATE SEQUENCE; CARRIER PROTEINS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ESCHERICHIA COLI; GLYCOSYLTRANSFERASES; HEXOSYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES;

EID: 0034090551     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.5.1181-1185.2000     Document Type: Article

References (29)

1. Anderson, J. S., M. Matsuhashi, M. A. Haskin, and J. L. Strominger. 1967. Biosynthesis of the peptidoglycan of bacterial cell walls. II. Phospholipid carriers in the reaction sequence. J. Biol. Chem. 242:3180-3190.
2. Brötz, H., G. Bierbaum, P. E. Reynolds, and H.-G. Sahl. 1997. The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation. Eur. J. Biochem. 246:193-199.
3. Casabadan, M. J., and S. N. Cohen. 1980. Analysis of gene control signals by DNA fusion and cloning in Escherichia coli J. Mol. Biol. 138:179-207.
4. Dargis, M., and F. Malouin. 1994. Use of biotinylated β-lactams and chemiluminescence for study and purification of penicillin-binding proteins in bacteria. Antimicrob. Agents Chemother. 38:973-980.
5. Edwards, D. H., and W. D. Donachie. 1993. Construction of a triple deletion of penicillin-binding proteins 4, 5 and 6 in Escherichia coli, p. 369-374. In M. A. de Pedro, J.-V. Höltje, and W. Löffelhardt (ed.), Bacterial growth and lysis. Plenum Press, New York, N.Y.
6. Ghuysen, J.-M. 1994. Biochemistry of the penicilloyl serine transferases, p. 103-129. In J.-M. Ghuysen and R. Hakenbeck (ed.), Bacterial cell wall. Elsevier, Amsterdam, The Netherlands.
7. Goffin, C., and J.-M. Ghuysen. 1998. Multimodular penicillin binding proteins: an enigmatic family of orthologs and paralogs. Microbiol. Mol. Biol. Rev. 62:1079-1093.
8. Huber, G., and G. Nesemann. 1968. Moenomycin, an inhibitor of cell wall synthesis Biochem. Biophys. Res. Commun. 30:7-13.
9. Ishino, F., K. Mitsui, S. Tamaki, and M. Matsuhashi. 1980. Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations of Escherichia coli penicillin-binding protein 1A. Biochem. Biophys. Res. Commun. 97:287-293.
10. Kelly, J. A., P. C. Moews, J. R. Knox, J. M. Frère, and J. M. Ghuysen. 1982. Penicillin target enzyme and the antibiotic binding site. Science 218:479-481.
11. Matsuhashi, M. 1994. Utilization of lipid-linked precursors and the formation of peptidoglycan in the proces of cell growth and division: membrane enzymes involved in the final steps of peptidoglycan synthesis and mechanism of their regulation, p. 55-71. In J.-M. Ghuysen and R. Hakenbeck (ed.), Bacterial cell wall. Elsevier, Amsterdam, The Netherlands.
12. Nakagawa, J., S. Tamaki, and M. Matsuhashi. 1979. Purified penicillin binding proteins 1Bs from Escherichia coli membrane showing activities of both peptidoglycan polymerase and peptidoglycan crosslinking enzyme. Agric. Biol. Chem. 43:1379-1380.
13. Neu, H. C., N. X. Chin, and W. W. Niu. 1992. In vitro activity of the new glycopeptide decaplanin. Eur. J. Clin. Microbiol. Infect. Dis. 11:458-462.
14. Park, J. T. 1996 The murein sacculus, p. 48-57. In F. C. Neidhardt (ed.), Escherichia coli and Salmonella. American Society for Microbiology, Washington, D.C.
15. Rogers, H. J., H. R. Perkins, and J. B. Ward. 1980. Microbial cell walls and membranes. Chapman & Hall, London, United Kingdom.
16. Schiffer, G., and J.-V. Höltje. 1999. Cloning and characterization of PBP 1C, a third member of the multimodular class A of penicillin-binding proteins of Escherichia coli J. Biol. Chem. 274:32031-32039.
17. Spratt, B. G. 1975. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc. Natl. Acad. Sci. USA 72:2999-3003.
18. Tipper, D. J., and J. L. Strominger. 1965. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proc. Natl. Acad. Sci. USA 54:1133-1141.
19. Tomasz, A. 1986. Penicillin-binding proteins and the antibacterial effectiveness of beta-lactam antibiotics. Rev. Infect. Dis. 8(Suppl. 3):260-378.
20. Umbreit, J. N., and J. L. Strominger. 1972. Isolation of the lipid intermediate in peptidoglycan biosynthesis from Escherichia coli. J. Bacteriol. 112:1306-1309.
21. van Heijenoort, J. 1994. Biosynthesis of the bacterial peptidoglycan unit, p. 39-54. In J.-M. Ghuysen and R. Hakenbeck (ed.), Bacterial cell wall. Elsevier, Amsterdam, The Netherlands.
22. van Heijenoort, Y., M. Derrien, and J. van Heijenoort. 1978. Polymerization by transglycosylation in the biosynthesis of the peptidoglycan of Escherichia coli K12 and its inhibition by antibiotics FEBS Lett. 89:141-144.
23. van Heijenoort, V., and J. van Heijenoort. 1980. Biosynthesis of the peptidoglycan of Escherichia coli K12-properties of the in vitro polymerization by transglycosylation. FEBS Lett. 110:241-244.
24. Vollmer, W., M. von Rechenberg, and J.-V. Höltje. 1999. Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli. J. Biol. Chem. 274:6726-6734.
25. Waxman, D. J., and J. L. Strominger. 1983. Penicillin. Annu. Rev. Biochem. 52:825-869.
26. Welzel, P., F. Kunisch, F. Kruggel, H. Stein, J. Scherkenbeck, A. Hiltmann, H. Dudeck, D. Müller, J. E. Maggio, H.-W. Fehlhaber, G. Seibert, Y. van Heijenort and J. van Heijenoort. 1987. Moenomycin A: minimum structural requirements for biological activity. Tetrahedron 43:585-598.
27. Wise, E. M., Jr., and J. T. Park. 1965. Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis. Proc. Natl. Acad. Sci. USA 54:75-81.
28. Yousif, S. Y., J. K. Broome-Smith, and B. G. Spratt. 1985. Lysis of Escherichia coli by β-lactam antibiotics: deletion analysis of the role of penicillin-binding proteins 1A and 1B. J. Gen. Microbiol. 131:2839-2845.
29. Zhao, G., T. I. Meier, S. D. Kahl, K. R. Gee, and L. C. Blaszczak. 1999. Bocillin FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins. Antimicrob. Agents Chemother. 43:1124-1128.