Design and synthesis of potent antitumor 5,4'-diaminoflavone derivatives based on metabolic considerations

Journal of Medicinal Chemistry

Volumn 40, Issue 12, 1997, Pages 1894-1900

  Akama, Tsutomu ^a   Ishida, Hiroyuki ^a   Shida, Yasushi ^a   Kimura, Uichiro ^a   Gomi, Katsushige ^a   Saito, Hiromitsu ^a   Fuse, Eiichi ^a   Kobayashi, Satoshi ^a   Yoda, Nobuyuki ^a   Kasai, Masaji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4',5 DIAMINO 3',6,8 TRIFLUOROFLAVONE; 5,4' DIAMINOFLAVONE; ESTROGEN RECEPTOR; FLAVONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUDE MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DIVISION; DRUG DESIGN; ENDOMETRIAL NEOPLASMS; FEMALE; FLAVONOIDS; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; OVARIAN NEOPLASMS; RECEPTORS, ESTRADIOL; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 15444358404     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9700326     Document Type: Article

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