Structure-activity relationships of the 7-substituents of 5,4-'diamino- 6,8,3'-trifluoroflavone, a potent antitumor agent

Journal of Medicinal Chemistry

Volumn 41, Issue 12, 1998, Pages 2056-2067

  Akama, Tsutomu ^a   Ishida, Hiroyuki ^a   Kimura, Uichiro ^a   Gomi, Katsushige ^a   Saito, Hiromitsu ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 2 (4 AMINO 3 FLUOROPHENYL) 6,8 DIFLUORO 4H 4 OXO 1 BENZOPYRAN 7 YL METHYL ACETATE; 5 AMINO 2 (4 AMINO 3 FLUOROPHENYL) 6,8 DIFLUORO 7 (AMINOMETHYL) 4H 1 BENZOPYRAN 4 ONE; 5 AMINO 2 (4 AMINO 3 FLUOROPHENYL) 6,8 DIFLUORO 7 HYDROXY 4H 1 BENZOPYRAN 4 ONE; 5 AMINO 2 (4 AMINO 3 FLUOROPHENYL) 6,8 DIFLUORO 7 METHYL 4H 1 BENZOPYRAN 4 ONE; ANTINEOPLASTIC AGENT; APIGENIN; ESTRADIOL PROPIONATE; FLAVONE DERIVATIVE; GENISTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; INTRAMUSCULAR DRUG ADMINISTRATION; LIPOPHILICITY; NONHUMAN; NUDE MOUSE; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLAVONOIDS; HELA CELLS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0032482377     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970728z     Document Type: Article

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