Hypoxia and reoxygenation of brain microvascular smooth muscle cells in vitro: Cellular responses and expression of cerebral amyloid angiopathy-associated proteins

APMIS

Volumn 110, Issue 5, 2002, Pages 423-434

  Wang, Zhenzhen ^a   Wu, Dafang ^a   Vinters, Harry V ^a  

^a UCLA MEDICAL CENTER   (United States)

Author keywords

Amyloid precursor protein; Cerebral amyloid angiopathy; Cystatin c; Hypoxia; Microvessel, cerebral; Smooth muscle cell, vascular

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; CEREBRAL AMYLOID ANGIOPATHY ASSOCIATED PROTEIN; CYSTATIN C; UNCLASSIFIED DRUG;

AORTA MEDIA; ARTICLE; BRAIN HYPOXIA; CELL ISOLATION; CELL LINE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROVASCULATURE; MITOSIS INHIBITION; NERVE CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REOXYGENATION; SMOOTH MUSCLE FIBER; VASCULAR AMYLOIDOSIS; VASCULAR SMOOTH MUSCLE;

AORTA; BACTERIAL OUTER MEMBRANE PROTEINS; BENZIMIDAZOLES; BLOTTING, WESTERN; BRAIN; CELL COUNT; CELLS, CULTURED; CYSTATINS; FLUORESCENT DYES; HUMANS; HYPOXIA, BRAIN; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; MUSCLE, SMOOTH, VASCULAR; OXYGEN; UP-REGULATION;

EID: 0036085269     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0463.2002.100509.x     Document Type: Article

References (54)

1. Pathophysiological aspects of brain edema
2. Blood-brain barrier permeability and brain concentration of sodium, potassium, and chloride during focal ischemia
3. Early blood-brain barrier changes in the rat following transient complete ischemia induced by cardiac arrest
4. Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer
5. Brain parenchymal and microvascular amyloid in Alzheimer's disease
6. Amyloid β-protein precursor in cultured leptomeningeal smooth muscle cells
7. Nonfibrillar beta-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer's disease
8. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
9. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
10. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
11. Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of γ-trace basic protein (cystatin C)
12. Immunohistochemical characterization of cerebrovascular amyloid in 46 autopsied cases using antibodies to β protein and cystatin C
13. Production and increased detection of amyloid β protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer disease
14. β-amyloid formation by myocytes of leptomeningeal vessels
15. Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls
16. Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat
17. Regional accumulation of amyloid β/A4 protein precursor in the gerbil brain following transient cerebral ischemia
18. Accumulation of the β amyloid precursor protein at sites of ischemic injury in rat brain
19. Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia
20. Amyloid β peptide and precursor protein (APP) in mild and severe brain ischemia
21. Ischemic stress induces deposition of amyloid β immunoreactivity of human brain
22. Arterial wall oxygenation, oxyradicals, and atherosclerosis
23. Non-CAA angiopathies and their possible interactions with cerebral amyloid angiopathy
24. Isolation and culture of cells derived from human cerebral microvessels
25. Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells
26. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
27. Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease
28. Immunohistochemical study of cerebral amyloid angiopathy. III. Widespread Alzheimer A4 peptide in cerebral microvessel walls colocalizes with gamma-trace in patients with leukoencephalopathy
29. Diversity of phenotype and function of vascular smooth muscle cells
30. Heterogeneous smooth muscle cell population derived from small and larger arteries
31. Microvascular degeneration in hereditary cystatin C amyloid angiopathy
32. Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: An immunohistochemical and ultrastructural study
33. Neuronal models to study amyloid precursor protein expression and processing in vitro
34. Intracellular accumulation of β-amyloid in cells expressing the Swedish mutant amyloid precursor protein
35. Enhanced release of amyloid β-protein from codon 670/671 "Swedish" mutant β-amyloid precursor protein occurs in both secretory and endocytic pathways
36. Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
37. Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells
38. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular β-amyloid or A4 peptides
39. Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing
40. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
41. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells
42. N-linked oligosaccharide of β-amyloid precursor protein (βAPP) of C6 glioma cells: Putative regulatory role in βAPP processing
43. Regulated O-glycosylation of the Alzheimer β-A4 amyloid precursor protein in thyrocytes
44. The role of glycosylation in synthesis and secretion of β-amyloid precursor protein by Chinese hamster ovary cells
45. The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells
46. Altered gene expression in cerebral ischemia
47. Cellular responses to experimental brain injury
48. The neuroprotective effects of the recombinant interleukin-1 receptor antagonist rhIL-1ra after excitotoxic stimulation with kainic acid and its relationship to the amyloid precusor protein gene
49. Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress
50. Relationship between severe amyloid angiopathy, apolipoprotein E genotype, and vascular lesions in Alzheimer's disease
51. Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease
52. Key factors in Alzheimer's disease: β-amyloid precursor protein processing, metabolism and intraneuronal transport
53. Apolipoprotein E, smooth muscle cells and the pathogenesis of cerebral amyloid angiopathy: The potential role of impaired cerebrovascular Aβ clearance
54. Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells