Serpin=serine protease-like complexes within neurofilament conglomerates of motoneurons in amyotrophic lateral sclerosis

Journal of the Neurological Sciences

Volumn 160, Issue SUPPL. 1, 1998, Pages

  Chou, Samuel M ^a   Taniguchi, Akira ^b   Wang, Helen S ^a   Festoff, Barry W ^c,d  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b MIE UNIVERSITY   (Japan)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

ALS, amyotrophic lateral sclerosis; Amyotrophic lateral sclerosis (ALS); Axonal spheroid (Axs); Axs, axonal spheroids; Cgl, conglomerate; Chymotrypsin=antichymotrypsin complex; Conglomerate (Cgl); Neuroserpin; Nf, neurofilaments; NfCg, neurofilament conglomerates; Serine protease; Thrombin=PNI complex; Trypsin=antitrypsin complex

Indexed keywords

SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; HUMAN; MOTONEURON; NEUROFILAMENT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALPHA 1-ANTICHYMOTRYPSIN; ALPHA 1-ANTITRYPSIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYOTROPHIC LATERAL SCLEROSIS; ANTIBODIES; ASTROCYTES; BRAIN; CARRIER PROTEINS; CHYMOTRYPSIN; HUMANS; IMMUNOHISTOCHEMISTRY; MICROGLIA; MOTOR NEURONS; NEUROFILAMENT PROTEINS; RECEPTORS, CELL SURFACE; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SERPINS; SPINAL CORD; THROMBIN; TRYPSIN;

EID: 0031782683     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00202-0     Document Type: Article

References (43)

1. Baker JB, Gronke RS. Protease nexin and cellular regulation. Semin Thromb Hemost 1986;12(3):216-20.
2. Baker JB, Low DA, Simmer RL, Cunningham DD. Protease-nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 1980;21:37-45.
3. Bolkenius FN, Monard D. Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals. Neurochem Int 1995;26:587-92.
4. Bolkenius FN. Leukocyte-mediated inactivation of alpha 1-proteinase inhibitor is inhibited by amino analogues of alpha-tocopherol. Biochim Biophys Acta 1991;1095(1):23-9.
5. Carter RE, Cerosaletti KM, Burkin DJ, et al. The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. Genomics 1995;27:196-9.
6. Choi BH, Kim RC, Vaughan PJ, et al. Decreases in protease nexin in Alzheimer's disease brain. Neurobiology 1995;16:557-62.
7. Chou SM. Neuropathology of amyotrophic lateral sclerosis: New perspectives on an old disease. J Formosan Med Assoc 1997;96:488-98.
8. Chou SM, Wang HS, Komai K. Colocalization of NOS and SOD-1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study. J Chem Neuroanatomy 1996;10:249-58.
9. Chou SM, Wang HS, Taniguchi A. Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/ MND. J Neurol Sci 1996;139(Suppl):16-26.
10. Chou SM. Pathology of motor system disorder. In: Leigh PN, Swash M, editors. Motor neuron disease: biology and management. London: Springer-Verlag, 1995:53-92.
11. Chou SM. Pathognomy of intraneuronal inclusions in ALS. In: Tsubaki T, Toyokura Y, editors. Amyotrophic lateral sclerosis. Tokyo: University of Tokyo Press, 1979:135-76.
12. Donovan FM, Vaughan FM, Cunningham DD. Regulation of protease nexin-I target protease specificity by collagen type IV. J Biol Chem 1994;269:199-205.
13. Estévez AG, Spear N, Manuel SM, et al. Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J Neurosci 1988;18:923-31.
14. Farrell DH, Wagner SL, Yuan RH, Cunningham DD. Localization of protease nexin-1 on the fibroblast extracellular matrix. J Cell Physiol 1988;134:179-88.
15. Festoff BW, Smirnova I, Ma J, Citron B. Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system. Semin Thromb Hemost 1996;22:267-71.
16. Festoff BW, Nelson PG, Brenneman DE. Prevention of activity-dependent neuronal death: vasoactive intestinal polypeptide stimulates astrocytes to secrete the thrombin-inhibiting, neurotrophic serpin, protease nexin I. J Neurobiol 1996;30:255-66.
17. Festoff BW, Reddy RB, Van Becelaere M, Smirnova I, Chao J. Activation of serpins and their cognate proteases in muscle after crush injury. J Cell Physiol 1994;159:11-8.
18. Festoff BW, Rao JS, Chen M. Protease nexin I, thrombin- and urokinase-inhibiting serpin, concentrated in normal human cerebrospinal fluid. Neurology 1992;42:1361-6.
19. Hantaï D, Akaaboune M, Verdiere-Sahuque M, Lachkar S, Festoff BW. Serine proteases and their inhibitors: their role in differentiation in the neuromuscular system. Compt Rend Seanc Soc Biol Sesf 1994;188:541-52.
20. Hentati A, Bejaoui K, Pericak-Vance MA, et al. Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. Nature Genetics 1994;7:425-8.
21. Hirano A, Donnenfield H, Sasaki S, Nakano I. Fine structural observations of neuro-filamentous changes in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 1984;43:461-70.
22. Ho GJ, Smirnova IV, Akaaboune M, Hantaï D, Festoff BW. Serine proteases and their serpin inhibitors in Alzheimer's disease. Biomed Pharmacother 1994;48:294-304.
23. Houenou LJ, Turner PL, Li L, Oppenheim RW, Festoff BW. A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death. Proc Natl Acad Sci 1995;92:895-9.
24. Hyman BT, Tanzi RE, Marzloff K, Barbour R, Schenk D. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J Neuropath Exp Neurol 1992;51:76-83.
25. Kato T, Katagili T, Shikama Y, et al. Heparan sulfate-like immunoreactivity in the spinal cord in motor neuron disease. Acta Neuropathol 1993;85:663-5.
26. 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein. J Biol Chem 1996;271:6523-9.
27. Mansuy IM, van der Putten H, Schmid P, Meins M, Botteri FM, Monard D. Variable and multiple expression of protease nexin-1 during mouse organogenesis and nervous system development. Development 1993;119:1119-34.
28. McLean WG, Pekiner C, Cullum NA, Casson IF, et al. Post-translational modifications of nerve cytoskeletal proteins in experimental diabetes. Mol Neurobiol 1992;6:225-37.
29. Monard D. Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth. Trends Neurosci 1988;11:541-4.
30. Nitsch C, Scotti AL, Monard D, Heim C, Sontag KH. The gliaderived protease nexin I persists for over 1 year in rat brain areas selectively lesioned by transient global ischaemia. Eur J Neurosci 1993;5:292-7.
31. Osterwalder T, Contartese J, Stoeckli ET, Kuhn TB, Sonderegger P. Neuroserpin, an axonally secreted serine protease inhibitor. EMBO J 1996;15:2944-53.
32. Perlmutter DH, Joslin G, Nelson P, Schasteen C, Adams SP, Fallon RJ. Endocytosis and degradation of alpha 1-antitrypsin-protease complexes is mediated by the serpin-enzyme complex (SEC) receptor. J Biol Chem 1990;265:16713-6.
33. Rao JS, Chen M, Festoff BW. Plasminogen activator inhibitor 1, the primary regulator of fibrinolysis, in normal human cerebrospinal fluid. J Neurosci Res 1993;34(3):340-5.
34. Rayford A, Rao JS, Festoff BW. Characterization of the serpin, alpha 1-anti-chymotrypsin, in normal human cerebrospinal fluid. J Neurochem 1992;58:88-94.
35. Reinhard E, Suidan HS, Pavlik A, Monard D. Glia-derived nexin/ protease nexin-1 is expressed by a subset of neurons in the rat brain. Neuro Res 1994;37:256-70.
36. Rosenblatt DE, Geula C, Mesulam MM. Protease nexin I immunostaining in Alzheimer's disease. Ann Neurol 1989;26:628-34.
37. Schrimpf AP, Bleiker AJ, Brecevic L, et al. Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26. Genomics 1997;40:55-62.
38. Shibata N, Hirano M, Klapporth K. Immunohistochemical demonstration of Cu/Zn superoxide dismutase in the spinal cord of patients with familial amyotrophic lateral sclerosis. Acta Histochem Cytochem 1993;26:619-21.
39. Shibata N, Hirano A, Kobayashi M, et al. Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis. Neurosci Lett 1994;179:149-52.
40. Smirnova IV, Ho GJ, Fenton JW, Festoff BW. Extravascular proteolysis and the nervous system: serine protease/serpin balance. Semin Thromb Hemost 1994;20:426-32.
41. Smith-Swintosky VL, Zimmer S, Fenton JW, Mattson MP. Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury. J Neurosci 1995;15:5840-50.
42. Tsuneishi S. Regulation of neurite outgrowth through protein kinase C and protease nexin-1 in neuroblastoma cell. Kobe J Med Sci 1992;38:147-59.
43. Vaughan PJ, Pike CJ, Cotman CW, Cunningham DD. Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci 1995;15:5389-401.