Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation

Human Gene Therapy

Volumn 9, Issue 15, 1998, Pages 2253-2261

  McMasters, Robyn A ^a   Saylors, Robert L ^b   Jones, Kelly E ^a   Hendrix, Michael E ^c   Moyer, Mary Pat ^d   Drake, Richard R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c MISSOURI STATE UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; GAP JUNCTION PROTEIN; THYMIDINE KINASE; VIRUS ENZYME;

ARTICLE; CELL KILLING; CELL SURFACE; CELLULAR DISTRIBUTION; COLORECTAL CARCINOMA; CONTROLLED STUDY; GAP JUNCTION; GENE THERAPY; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; TUMOR CELL LINE;

HERPES; SIMPLEXVIRUS;

EID: 0032505770     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.15-2253     Document Type: Article

References (6)

1. BECK, C., CAYEUX, S., LUPTON, S.D., DORKEN, B., and BLANKENSTEIN, T. (1995). The thymidine kinase/ganciclovir-mediated "suicide" effect is variable in different tumor cells. Hum. Gene Ther. 6, 1525-1530.
2. BI, W.L., PARYSEK, L.M., WARNICK, R., and STAMBROOK, P.J. (1993). In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum. Gene Ther. 4, 725-731.
3. BI, W., KIM, Y.-G., FELICIANO, E.S., PAVELIC, L., WILSON, K.M., PAVELIC, Z.P., and STAMBROOK, P.J. (1997). An HSVTk-mediated local and distant antitumor bystander effect in tumors of head and neck origin in athymic mice. Cancer Gene Ther. 4, 246-252.
4. BOUCHER, P.D., RUCH, R.J., and SHEWACH, D.S. (1998). Differential ganciclovir mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase. Hum. Gene Ther. 9, 801-814.
5. BRISSETTE, J.L., KUMAR, N.M., GILULA, N.B., and DOTTO, G.P. (1991). The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins. Mol. Cell. Biol. 11, 5364-5371.
6. YANG, L., CHIANG, Y., LENZ, H., DANENBERG, K.D., SPEARS, C.P., GORDON, E.M., ANDERSON, W.F., and PAREKH, D. (1998). Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based gene therapy of human gastrointestinal tumor cells. Hum. Gene Ther. 9, 719-728.